Abstract: A stent is disclosed, which includes a stent body (2) and a single-radiopaque component (1) disposed at one or each of a proximal end and a distal end of the stent body (2). The stent body (2) is composed of rings and struts, and one part of the single-radiopaque component (1) is received in a receptacle (3) of the stent body (2) and another part of the single-radiopaque component (1) protrudes out of a surface of the stent body (2). The area of the protruding part (11) of the single-radiopaque component (1) is larger than an area of the embedded part (10), the presence of the protruding part (11) allowing the single-radiopaque component (1) to appear wider and thicker in a radiologic image, enhancing the radiopacity of the stent during surgery.

Abstract: A left atrial appendage (LAA) closure (1) and a system (6) for delivering the LAA closure are disclosed. The LAA closure (1) includes supporting struts (11), wherein the supporting struts (11) are distributed peripherally around a first hub (10) and extend outward, the supporting strut (11) bifurcates at a first position (110) into a left branch (111) and a right branch (112). The left branch (111) of each supporting strut (11) and the right branch (112) of an adjacent supporting strut join each other at a second position (113) and extend distally to form a distal end. The LAA closure further includes a supporting rod (12) between adjacent supporting struts (11) which ensures stability, absence of irregular deformation and lateral slippage, of the LAA closure (1). With the supporting rods (12) between the adjacent supporting struts (11), the LAA closure (1) forms a dense mesh which imparts high overall strength of the LAA closure (1).

Abstract: A cardiac pacemaker system and control methods thereof are disclosed, wherein pacing logic and timing functions are enabled by a microprocessor and sensing and pulse delivery capabilities are accomplished by a peripheral IC. The microprocessor communicates with the peripheral IC via serial interfaces and electrical level signals. This allows for full use of internal resources of the modern ultra-low power microprocessor, lowering the dependence of the system on the peripheral IC and reducing the effort required for digital circuit design.

Abstract: Disclosed is use of amlexanox or a salt thereof or a solvate thereof in preparation of a drug having an inhibitory action on the smooth muscle cells, in particular a drug for preventing and treating vascular restenosis. Further disclosed is a medical device, particularly a drug stent, the surface of which is distributed with amlexanox or the salt thereof or the pharmaceutical composition thereof. Amlexanox has an activity in inhibition of the proliferation of smooth muscle cells, has a low inhibitory property of the endothelial cell growth, is particularly suitable for applying on a medical device to prevent the incidence of vascular restenosis, while not delaying the repair of endothelium.

Abstract: A medical device for treating cardiac arrhythmia includes a microprocessor. A MCU configures the medical device to operate in a modified DVI (R) mode in which: when receiving a signal indicating the sensing of an atrial event, the MCU sets a PANP interval and sends to a time control unit a signal; if a scheduled post-ventricular atrial escaping interval is to end at a time not within the PANP internal, the MCU sends respective signals to a pacing control/generation unit and the time control unit to dictate the pacing control/generation unit and control a second timing unit to use a PAVI as a next ventricular escape interval; and if the scheduled post-ventricular atrial escaping interval is to end within the PANP interval, the MCU sends a signal to the time control unit, controlling the second timing unit to use the PAVI as the next ventricular escape interval.

Abstract: A biodegradable cross-linked polymer and methods of preparing same are provided. The biodegradable cross-linked polymer is formed from a biodegradable polymeric material having two or more arms, which is a random copolymer formed of a first monomer and a second monomer different from the first monomer. The first monomer is selected from the group consisting of L-lactide, DL-lactide, glycolid, ?-caprolactone, trimethylene carbonate, p-dioxanone, amino acid-derived polycarbonates and polyorthoesters. The second monomer is one or two selected from the group consisting of D-lactide, DL-lactide, glycolide, ?-caprolactone, trimethyl carbonate, salicylic acid, carbonates, amino acids and derivatives thereof. The biodegradable polymeric material has a molecular weight of from 5,000 to 1,200,000 and an intrinsic viscosity of from 0.1 to 9.0 dl/g. Each of the terminal groups on the arms of the biodegradable polymeric material is selected from the group consisting of hydroxyl amino and carboxyl groups.

Abstract: A left atrial appendage (LAA) closure (1) and a system (6) for delivering the LAA closure are disclosed. The LAA closure (1) includes supporting struts (11), wherein the supporting struts (11) are distributed peripherally around a first hub (10) and extend outward, the supporting strut (11) bifurcates at a first position (110) into a left branch (111) and a right branch (112). The left branch (111) of each supporting strut (11) and the right branch (112) of an adjacent supporting strut join each other at a second position (113) and extend distally to form a distal end. The LAA closure further includes a supporting rod (12) between adjacent supporting struts (11) which ensures stability, absence of irregular deformation and lateral slippage, of the LAA closure (1). With the supporting rods (12) between the adjacent supporting struts (11), the LAA closure (1) forms a dense mesh which imparts high overall strength of the LAA closure (1).

Abstract: A bipolar cardiac lead (100) is provided and includes a connector pin (112), a connector insulator (116), and a ring connector (130). The connector pin (112) has a proximal end and a distal end, and the proximal end is configured to engage an electrical stimulation device. The connector insulator (116) is coupled to the distal end of the connector pin (112) and may define a bore (118) configured for receiving a portion of the connector pin (112). The connector insulator (116) provides electrical insulation between the connector pin (112) and the ring connector (130). The ring connector (130) is coupled to the connector insulator (116) with a snap-fit connection and may be disposed around a portion of the connector insulator (116). The bipolar cardiac lead (100) may be an active or a passive lead.

Abstract: An alloy material and an implantable medical device using the alloy material are disclosed. The material contains the following elements in the weight percentages given: magnesium: less than 3%; selenium: 0.001%-0.5%; strontium: 0.001%-0.5%; zinc: the remainder.

Abstract: An active bipolar cardiac electrical lead includes a distal electrode (108), an intermediate connection mount (109), a ring electrode (103), and a tip housing (110). The intermediate connection mount (109) defines a proximal fitting (370) and a distal fitting (374). The ring electrode (103) has an exposed section (356) that sleeves over and engages the proximal fitting (370) of the intermediate connection mount (109) with a snap-fit connection. The intermediate connection mount (109) may connect the ring electrode (103) to the tip housing (110) and provide electrical insulation between the ring electrode (103) and the distal electrode (108).

Abstract: An active bipolar cardiac electrical lead includes a distal electrode (108), an intermediate connection mount (109), a ring electrode (103), and a tip housing (110). The intermediate connection mount (109) defines a proximal fitting (370) and a distal fitting (374). The ring electrode (103) has an exposed section (356) that sleeves over and engages the proximal fitting (370) of the intermediate connection mount (109) with a snap-fit connection. The intermediate connection mount (109) may connect the ring electrode (103) to the tip housing (110) and provide electrical insulation between the ring electrode (103) and the distal electrode (108).

Abstract: A degradable polyester stent is disclosed, which includes a polyester composite, wherein the polyester composite is produced from a biodegradable polyester and a metal-based material. A method of preparing the degradable polyester stent is also disclosed. The method can improve the mechanical properties of the biodegradable copolymer stent and can achieve the radiopacity of the main body and the overall of the stent.

Abstract: A proximal end of an implantable lead may include a connector insulator having a center bore, a unitary connector pin fixedly disposed in the center bore of the connector insulator where the unitary connector pin includes a socket end configured for insertion into an electrical stimulation device and a conductor end electrically crimped to the first conductor, and a unitary ring connector having a band portion concentrically arranged around and insulated from the conductor end of the unitary connector pin and a crimp portion electrically crimped to the second conductor.

Abstract: An active bipolar cardiac electrical is assembled by coupling an inner conductor coil to a connector pin to form an inner conductor assembly. The inner conductor assembly is threaded through a connector insulator. An insulating tubing is placed over the inner coil. A proximal end of the insulating tubing is sleeved over the distal extension of the connector insulator. An outer conductor coil is coupled to a ring connector to form an outer conductor assembly. The inner conductor assembly is threaded through the outer conductor assembly. The ring connector is sleeved on the distal extension of the connector insulator and over the insulator tubing. A proximal seal is sleeved over a socket end of the connector pin. The proximal seal is seated on the proximal extension of the connector insulator.

Abstract: A passive cardiac electrical lead is assembled by coupling an inner conductor coil to a connector pin to form an inner conductor assembly. The inner conductor assembly is threaded through a connector insulator. An insulator tubing is placed over the inner coil. A proximal end of the insulator tubing is sleeved over the distal extension of the connector insulator. An outer conductor coil is coupled to a ring connector to form an outer conductor assembly. The inner conductor assembly is threaded through the outer conductor assembly. The ring connector is sleeved on the distal extension of the connector insulator and over the insulator tubing. A proximal seal is sleeved over a socket end of the connector pin. A portion of the proximal seal is seated on the proximal extension of the connector insulator.

Abstract: An implant capsule (10) and an implant delivery system are disclosed. The implant capsule (10) includes, sequentially from a proximal end to a distal end, a flexural section (102, 102a-102e), a reinforcement section (101, 101a-101e) and a radiopaque reinforcement ring (104a-104e). The reinforcement section (101, 101a-101e) has higher strength than the flexural section (102, 102a-102e). The implant delivery system includes the implant capsule (10). The implant capsule (10) can ensure the implant to be deployed in a coaxial condition and prevent over-expansion due to large expansion forces exerted by a stent of the implant.

Abstract: An interventional medical device and manufacturing method thereof. The interventional medical device comprises: a stent body (1); a surface of the stent body (1) being provided with a drug releasing structure (3), and drug in the drug releasing structure (3) being drug for suppressing proliferation of adventitial fibroblasts and a drug for suppressing proliferation of intimal and/or smooth muscle cells. In use, after interventional medical device is implanted into a human body, the drug for suppressing proliferation of adventitial fibroblasts carried thereon can promote the compensatory expansion of the vessel, and the drug for suppressing proliferation of intimal cells and/or smooth muscle cells carried thereon can suppress intimal proliferation of the vessel. The combination of the two kinds of drugs greatly reduces the occurrence rate of in-stent restenosis.

Abstract: A method for loading a medical appliance with a medicament and/or a polymer is disclosed, the medical appliance comprising one or more grooves or holes loaded with the medicament and/or polymer. The method comprising the steps of: 1) capturing an image of the grooves or holes of the medical appliance, wherein the image contains at least one complete pattern of the grooves or holes; 2) performing digital image processing on the captured image to obtain the pattern of the grooves or holes; 3) calculating a central position of the pattern of the grooves or holes, and determining an actual central position of the grooves or holes based on the central position; 4) adjusting a relative position of a loading device to the medical appliance to align an outlet of the loading device with the actual central position of the grooves or holes; and 5) opening the outlet of the loading device to load the grooves or holes. A device for loading a medical appliance with a medicament and/or a polymer is further disclosed.

Abstract: An active bipolar cardiac electrical lead includes a helical anchor electrode, a tip electrode pin, an intermediate connection mount, a ring electrode, and a tip housing. The tip electrode pin engages an inner conductor coil at a proximal end and engages a proximal end of the helical anchor electrode at a distal end. The intermediate connection mount defines an axial lumen therethrough, a proximal fitting, a cylindrical flange, and a distal fitting. The ring electrode has an exposed section that sleeves over and connects with the proximal fitting of the intermediate connection mount and has a proximal sleeve that engages with an outer conductor coil and an outer sheath of the lead. The tip housing defines an axial bore that houses the helical anchor electrode and a distal portion of the tip electrode pin.

Abstract: A stent for a bifurcated vessel includes a stent body (1) with two open ends (5, 6). The stent body (1) includes multiple sets of annular units (2) having multiple undulating rods (4) and connecting rods (3) positioned between adjacent annular units (2) and used to connect the adjacent annular units (2). At least one open end (6) of the stent body (1) has a slope structure.