Patents Assigned to SHANGHAI PHARMAEXPLORER CO., LTD.
  • IL-13 antibody and preparation method and use thereof
    Patent number: 11136387
    Abstract: The present invention discloses IL-13 antibody, method of its preparation and use thereof. The IL-13 antibody comprises one or more of heavy chain CDR1, heavy chain CDR2 and heavy chain CDR3 of heavy chain variable region of the IL-13 antibody, and/or one or more of light chain CDR1, light chain CDR2, and light chain CDR3 of light chain variable region of the IL-13 antibody. The IL-13 antibody has a high affinity and can significantly inhibit the secretion of thymus activation-regulated chemokine and periostin as well as the expression of vascular cell adhesion molecule-1 induced by IL-13, it can significantly inhibit airway hyperresponsiveness in mice induced by IL-13, and therefore can be used in the preparation of drugs for preventing or treating IL-13 expression or dysfunction related diseases.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: October 5, 2021
    Assignee: SHANGHAI PHARMAEXPLORER CO., LTD.
    Inventors: Yizhen Yang, Shiyong Gong, Lijuan Hao, Jian Wu, Xinxiu Yang, Qin Zhong, Shaoping Hu, Stewart Leung, Qing Duan, Lile Liu
  • ANTI-HUMAN LAG-3 MONOCLONAL ANTIBODY AND USE THEREOF
    Publication number: 20210155689
    Abstract: Disclosed in the present invention are an antibody targeting LAG-3, a preparation method therefor and the use thereof. In particular, disclosed in the present invention is a novel monoclonal antibody targeting LAG-3. Also disclosed in the present invention is a method for the preparation of the monoclonal antibody. The monoclonal antibody of the present invention is capable of binding LAG-3 antigens with high specificity, and has very high affinity and significant activities such as anti-tumor activity.
    Type: Application
    Filed: April 2, 2019
    Publication date: May 27, 2021
    Applicants: SHANGHAI PHARMAEXPLORER CO., LTD., PHARMAEXPLORER LIMITED
    Inventors: Ningning SONG, Qing DUAN, Xiaohui SHAO, Peng WANG, Xiaojiao BIAN, Qian WANG, Peipei WEI, Yajun HUANG, Jian WU, Meiling WANG, Yuandong WANG, Lina XU, Tatchi Teddy YANG, Lile LIU
  • IL-13 ANTIBODY AND PREPARATION METHOD AND USE THEREOF
    Publication number: 20190309059
    Abstract: The present invention discloses IL-13 antibody, method of its preparation and use thereof. The IL-13 antibody comprises one or more of heavy chain CDR1, heavy chain CDR2 and heavy chain CDR3 of heavy chain variable region of the IL-13 antibody, and/or one or more of light chain CDR1, light chain CDR2, and light chain CDR3 of light chain variable region of the IL-13 antibody. The IL-13 antibody has a high affinity and can significantly inhibit the secretion of thymus activation-regulated chemokine and periostin as well as the expression of vascular cell adhesion molecule-1 induced by IL-13, it can significantly inhibit airway hyperresponsiveness in mice induced by IL-13, and therefore can be used in the preparation of drugs for preventing or treating IL-13 expression or dysfunction related diseases.
    Type: Application
    Filed: May 16, 2017
    Publication date: October 10, 2019
    Applicant: SHANGHAI PHARMAEXPLORER CO., LTD.
    Inventors: Yizhen YANG, Shiyong GONG, Lijuan HAO, Jian WU, Xinxiu YANG, Qin ZHONG, Shaoping HU, Stewart LEUNG, Qing DUAN, Lile LIU