Abstract: The present invention relates to a brivaracetam intermediate, a preparation method therefor, and a preparation method for brivaracetam. The steps of the method for preparing brivaracetam described in the present invention are short and the raw materials are cheap, moreover, the method is simple and highly effective without requiring isomer separation by means of column chromatography or asymmetric synthesis, being suitable for industrial large-scale production. In addition, disclosed by the present invention is a compound as shown in formula (II), which may be used for the synthesis of brivaracetam.
Type:
Grant
Filed:
October 30, 2018
Date of Patent:
December 6, 2022
Assignee:
SHANGHAI PUYI CHEMICAL CO., LTD.
Inventors:
Hanrong Yang, Yantao Qi, Tao Li, Bo Wang
Abstract: The present invention relates to a brivaracetam intermediate, a preparation method therefor, and a preparation method for brivaracetam. The steps of the method for preparing brivaracetam described in the present invention are short and the raw materials are cheap, moreover, the method is simple and highly effective without requiring isomer separation by means of column chromatography or asymmetric synthesis, being suitable for industrial large-scale production. In addition, disclosed by the present invention is a compound as shown in formula (II), which may be used for the synthesis of brivaracetam.
Type:
Application
Filed:
October 30, 2018
Publication date:
August 19, 2021
Applicant:
SHANGHAI PUYI CHEMICAL CO., LTD.
Inventors:
Hanrong YANG, Yantao QI, Tao LI, Bo WANG
Abstract: The present invention relates to thiazole compounds of formula I, the method for preparation and use thereof. More specifically, the present invention relates to novel derivatives of natural product largazole, the method for preparing them and their uses for treatments against tumor and multiple sclerosis as inhibitors of histone deacetylase.