Patents Assigned to SHANGHAI SIMRD BIOTECHNOLOGY CO., LTD
  • TRIAZOLOPYRIDAZINE DERIVATIVE, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF
    Publication number: 20230136194
    Abstract: Provided is a triazolopyridazine derivative, a preparation method therefor, a pharmaceutical composition thereof, and an application thereof. The triazolopyridazine derivative is represented by formula I. The triazolopyridazine derivative has excellent inverse agonistic activity, thermodynamic solubility, bioavailability, and pharmacokinetic properties; thus having promising application prospects.
    Type: Application
    Filed: December 16, 2020
    Publication date: May 4, 2023
    Applicants: SHANGHAI SIMR BIOTECHNOLOGY CO., LTD., SHANGHAI SIMRD BIOTECHNOLOGY CO., LTD.
    Inventors: Yun Jin, Fei Wang, Jinhua Wu, Nanyang Chen, Yong Sun, Shuai Li
  • Substituted [1,2,4]triazolo[3,4-a]phthalazines as modulators of GABAreceptor activity
    Patent number: 11512089
    Abstract: The present invention discloses phthalazine isoxazole alkoxy derivatives, a preparation method thereof, a pharmaceutical composition, and a use thereof. The present invention provides a compound represented by Formula I, cis-trans isomers thereof, enantiomers thereof, diastereoisomers thereof, racemates thereof, solvates thereof, hydrates thereof, and pharmaceutically acceptable salts or prodrugs thereof. The compound has an excellent inverse agonist effect with respect to ?5-GABAA.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: November 29, 2022
    Assignees: SHANGHAI SIMR BIOTECHNOLOGY CO., LTD, SHANGHAI SIMRD BIOTECHNOLOGY CO., LTD
    Inventors: Fei Wang, Jinhua Wu, Yun Jin, Yong Sun, Shuai Li