Abstract: The invention provides a device, a kit for repairing and fixing articular cartilage, and a method for the same. The device comprises a costal cartilage rod, an outer sleeve, a drilling part, and an auxiliary implantation component; the drilling part comprises a drill sleeve and a drill bit matching an inner diameter of the drill sleeve; the auxiliary implantation component comprises a cartilage rod sleeve and an auxiliary pushing element, the costal cartilage rod has a rod-shaped structure with a diameter ranging from 3 mm to 8 mm and less than an inner diameter of the cartilage rod sleeve, and the costal cartilage rod is obtained from processing of costal cartilage. The costal cartilage is selected from the group consisting of autologous costal cartilage, allogeneic costal cartilage, or xenogeneic costal cartilage. Costal cartilage is processed into a costal cartilage rod by using the device provided in the present invention.

Abstract: A cobaltosic oxide-loaded titanium dioxide heterojunction nanozyme and a preparation method therefor and an application thereof are provided. The cobaltosic oxide-loaded titanium dioxide heterojunction nanozyme includes a surface oxygen vacancy doped TiO2-x nanosheet and a variable-valence metal-containing Co3O4 nanozyme, wherein the Co3O4 nanozyme is loaded on the surface of the TiO2-x nanosheet to construct and obtain the Co3O4@TiO2-x heterojunction nanozyme. The Co3O4@TiO2-x heterojunction nanozyme is used as a nanozyme to catalyze and generate endogenous O2 and consume GSH, so as to improve the tumor microenvironment (TME), and achieve the effect of eradicating tumors by cooperating with sonodynamic therapy and catalytic therapy.

Abstract: The invention discloses a plague removal device, comprising, a push catheter, a plaque scraping stent, a support tube, an elastic filter membrane, a guide catheter, and a handle, wherein the plaque scraping stent is a mesh structure sleeved outside the support tube, a distal end of the plaque scraping stent is fixed on a distal end of the support tube, a proximal end of the plaque scraping stent is fixed on a distal end of the push catheter, the support tube is sleeved inside the push catheter; a distance between the distal end of the push catheter and the distal end of the support tube is adjusted by the handle, so that an outer diameter of the plaque scraping stent is varied. The unique structure design of “tapered structure” in the present invention can ensure good compliance during the entry and withdrawal of the stent.

Abstract: The invention discloses a hard tissue slice anti-falling pretreatment device which comprises a box and a slice frame, a buffer plate is arranged in the box, and a plurality of small holes are evenly formed in the buffer plate; the bottom of the box is communicated with a liquid discharge pipe through a liquid outlet, and the liquid discharge pipe is provided with a valve; the slice frame is arranged on the buffer plate and comprises two longitudinal support frames and a plurality of layers of transverse support frames fixed between the two longitudinal support frames; each layer of transverse support frame comprises a plurality of first support rods, the gradient of each first support rod relative to the horizontal plane is 0-15 degrees.

Abstract: The invention discloses a plague removal device, comprising, a push catheter, a plaque scraping stent, a support tube, an elastic filter membrane, a guide catheter, and a handle, wherein the plaque scraping stent is a mesh structure sleeved outside the support tube, a distal end of the plaque scraping stent is fixed on a distal end of the support tube, a proximal end of the plaque scraping stent is fixed on a distal end of the push catheter, the support tube is sleeved inside the push catheter; a distance between the distal end of the push catheter and the distal end of the support tube is adjusted by the handle, so that an outer diameter of the plaque scraping stent is varied. The unique structure design of “tapered structure” in the present invention can ensure good compliance during the entry and withdrawal of the stent.

Abstract: The invention provides a novel hard tissue slicing knife, comprising a knife back portion and a knife edge portion which are manufactured as a single piece; wherein the knife back portion has a cross section of an isosceles trapezoid, the knife edge portion has a cross section of an isosceles triangle; an end of the knife back portion which is away from the knife edge portion, has a thickness in a range of 4 mm to 15 mm; a junction between the knife back portion and the knife edge portion has a thickness in a range of 0.1 mm to 0.8 mm; the knife hack portion has a vertical height in a range of 27 mm to 38 mm; two faces of the knife edge portion is at an angle in a range of 10 degrees to 40 degrees.

Abstract: The invention relates to a graft for repairing articular cartilage defects, comprising at least one of an autologous costal cartilage or an allogeneic costal cartilage, wherein the graft can be a whole piece of costal cartilage or a cartilage particle-bound hydrogel graft. The invention further relates to the use of the graft and a method for repairing articular cartilage defects. In the present invention, it has a small secondary injury by using costal cartilage implantation. In addition, it can be a minimally invasive operation, avoiding the risk of complications such as prosthesis loosening and infection due to the artificial joint replacement. Because the amount of costal cartilage is sufficient, it can meet the needs of multiple cartilage reconstruction and revision surgeries. Individualized reconstruction of injured articular cartilage surface can be achieved, which provides a safer, more operable repair method for patients diagnosed with articular cartilage defects.

Abstract: In one aspect, provided herein are set of primers and use of the same for the detection of SNPs associated with diabetes. In certain embodiments, the primers used to detect SNP sites associated with diabetes comprise Primer Set 1 to Primer Set 47. The experiments show: the genotyping results of the SNP sites associated with diabetes can be accurately detected by the primers disclosed herein, and the risk of individuals can be comprehensively evaluated and the result is more accurate than the single site analysis. In addition, SNPs disclosed herein are verified as associated with type 2 diabetes and its complications, which are especially suitable for the prevention and individualized treatment for type 2 diabetes in East Asian, for example, in China.