Abstract: The invention discloses a tissue engineering graft, comprising:(a) pharmaceutically-acceptable biodegradable material; and (b) seed cells, which can be inoculated on the described biodegradable material and are selected from:(i) fibroblasts; (ii) adipose derived cells, or (iii) mixture of dermal fibroblasts and ASCs according to the ratio of 1:10000-10000:1. The graft can be prepared by mixing of seed cell and pharmaceutically-acceptable biodegradable material, obtaining a construct of seed cells and pharmaceutically-acceptable biodegradable material, then culturing the construct in a bioreactor in vitro. The graft can be used for repairing the defect of tendon tissues.
Type:
Application
Filed:
December 29, 2009
Publication date:
August 5, 2010
Applicants:
SHANGHAI TISSUE ENGINEERING LIFE SCIENCE CO. LTD., Shanghai 9th People's Hospital, Shanghai Jiaotong University School of Medicine
Inventors:
Yilin Cao, Wei Liu, Feng Xu, Dan Deng, Hong Li, Lei Cui