Abstract: Disclosed is a real-time dynamic and quantitative detection device for carbon dioxide in human exhaled air, which comprises: a face mask which comprises an air inlet and an air outlet; an inhalation channel connected with the air inlet of the face mask, a first one-way valve is provided in the inhalation channel; an exhalation channel connected with the air outlet of the face mask, a second one-way valve is provided in the exhalation channel; an air path switching element connected with the exhalation channel to realize the switching between an exhalation air path to be detected and an inflation air path; a detection air chamber connected with the exhalation channel, at least one carbon dioxide sensor connected with an external upper computer is provided in the detection air chamber; before detection, the air path switching element switches to the inflation air path to clean and initialize the detection air chamber; during detection, the air path switching element switches to the exhalation air path to be det

Abstract: A tumor stroma imaging agent with a chemical structural formula (I): is provided, where R is hydrogen or fluorine. Compared with the prior art, the tumor stroma imaging agent exhibits significant affinity for fibroblast activation protein (FAP), high uptake for a malignant tumor with high FAP expression in a tumor stroma, and high sensitivity and specificity for the diagnosis of a malignant tumor, and is not prone to false positives. Therefore, the tumor stroma imaging agent can be effectively and safely used for the diagnosis and treatment of various malignant tumors with a prolonged half-life and an extended window period, which is conducive to clinical application.

Abstract: Arginine deiminase (ADI)-containing genetically engineered Corynebacterium glutamicum (C. glutamicum), a fusion protein cipA-arc, use thereof, and a method for preparing [14/15N]-L-citrulline through enzymatic catalysis are provided. The ADI-containing genetically engineered Corynebacterium glutamicum (C. glutamicum) has a deposit number of CGMCC No. 19404, which expresses a fusion protein cipA-arc. Both the genetically engineered strain and the fusion protein cipA-arc can be used to convert [14/15N]-L-arginine into [14/15N]-L-citrulline.

Abstract: The invention relates to a radioactive I-labeled Larotrectinib compound and a preparation method and application thereof, including a radioactive I-labeled Larotrectinib compound having the following structural formula and its analogs: where R1 and R2 are respectively H, F, Cl, Br, 123I, 124I, 125I, 130I or 131I, and at least one of R1 and R2 is a radioactive iodine element. The invention provides a preparation method of a radioiodinated pyrazolo[1,5-a]pyrimidine compound base. Radioiodinated pyrazolo[1,5-a]pyrimidine compounds with long half-life and different ray energy can be used for PET tomography and clinical diagnostic research of SPECT. Moreover, the high-energy radioiodinated pyrazolo[1,5-a]pyrimidine can act as a TrK receptor ligand to inhibit the activity of TRK and kill tumor cells; and due to high-energy I-131 ray energy carried, the radioiodinated pyrazolo[1,5-a]pyrimidine can coordinate to shoot tumor cells and thus achieve an accurate radiotherapy effect.