Patents Assigned to SHANGHAI WD PHARMACEUTICAL CO., LTD
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Patent number: 11911513Abstract: Disclosed are a controlled-release dosage form with an absorption window in the upper gastrointestinal tract and a preparation method therefor, wherein the controlled-release dosage form comprises a controlled-release platform and a retention platform. The controlled-release platform is a pharmaceutical composition comprising a tablet core and a coating membrane; and the retention platform holds the controlled-release platform in the oral cavity. The operation steps of the controlled-release dosage form are as follows: placing the controlled-release platform in the retention platform, and fixing the retention platform on matching teeth in the oral cavity; taking out the controlled-release dosage form after 4-24 hours and replacing same with a new controlled-release platform; and re-fixing the retention platform on the matching teeth in the oral cavity to achieve the sustained and stable release of drugs.Type: GrantFiled: November 23, 2020Date of Patent: February 27, 2024Assignee: SHANGHAI WD PHARMACEUTICAL CO., LTDInventors: Liang Chang Dong, Xishan Chen, Jingmin Shi, Danyong Zhang, Gang Wu
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Patent number: 11771690Abstract: A solid particle, a preparation method therefor, and a pharmaceutical composition. The solid particle comprises a porous solid particle and a non-aqueous liquid formula. The non-aqueous liquid formula comprises 0.10-4.00 wt % of a hydrophobic active pharmaceutical agent, 28.00-99.90 wt % of a hydrophobic solubilizing solution, 0-70.00 wt % of a non-ionic surfactant, and 0-1.00 wt % of an antioxidant. The hydrophobic solubilizing solution comprises a medium-chain monoglyceride and diglyceride, and/or a propylene glycol fatty acid monoester.Type: GrantFiled: November 27, 2018Date of Patent: October 3, 2023Assignee: SHANGHAI WD PHARMACEUTICAL CO., LTDInventors: Liang Chang Dong, Wenbo Ma, Lin Wang
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Patent number: 11759417Abstract: Disclosed are a pharmaceutical composition, an osmotic pump controlled-release drug delivery system comprising the pharmaceutical composition and a preparation method therefor. The pharmaceutical composition comprises a tablet core and a coating film. The tablet core comprises a drug-pulling layer, and the coating film comprises 50-90 wt % of cellulose acetate and 10-50 wt % of Copovidone. The Copovidone can be obtained by means of the polymerization of vinyl pyrrolidone and vinyl acetate in a molar ratio of 40:60-80:20.Type: GrantFiled: February 28, 2019Date of Patent: September 19, 2023Assignee: SHANGHAI WD PHARMACEUTICAL CO., LTDInventors: Liang Chang Dong, Xishan Chen
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Patent number: 11707455Abstract: Disclosed is a pharmaceutical composition containing dabigatran etexilate and a preparation method thereof. The pharmaceutical composition comprises a pharmaceutically active ingredient, dabigatran etexilate and/or dabigatran etexilate mesylate, and a amphiphilic polymer of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer. The mass ratio of the two is 1:0.23 to 1:3. The pharmaceutical composition not only increases the bioavailability of the pharmaceutically active ingredient, but also reduces absorption variability, and provides a more stable concentration of dabigatran in plasma, thereby reducing adverse side effects.Type: GrantFiled: November 27, 2018Date of Patent: July 25, 2023Assignee: SHANGHAI WD PHARMACEUTICAL CO., LTDInventors: Liang Chang Dong, Shizhong Zhang, Yan Jiao, Danyong Zhang, Wenfang Zhao, Jingmin Shi
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Publication number: 20220110832Abstract: Disclosed is an oral drug delivery device, comprising a tubular member, a drug holding part, a device cap and a turbulence-creating means. The tubular member has openings at both ends and an inner cavity; the opening at one end is a first opening and the opening at the other end is a second opening; the inner cavity communicates the first opening and the second opening. The turbulence-creating means comprises a step structure or a fold structure, and is disposed in the inner cavity and positioned between the second opening and the drug holding part. By using the oral drug delivery device of the present invention, turbulence can be generated during a normal sipping process, thereby providing ample mixing of drug-containing granules or multi-particulates with drinkable liquids. Moreover, the device is telescopic, which reduces the size and is convenient to carry.Type: ApplicationFiled: January 22, 2020Publication date: April 14, 2022Applicant: SHANGHAI WD PHARMACEUTICAL CO., LTDInventors: Liang Chang DONG, Yang LEI, Gang WU, Yan JIAO, Jingmin SHI
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Publication number: 20210369695Abstract: Disclosed is a pharmaceutical composition containing dabigatran etexilate and a preparation method thereof. The pharmaceutical composition comprises a pharmaceutically active ingredient, dabigatran etexilate and/or dabigatran etexilate mesylate, and an polymer of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer. The mass ratio of the two is 1:0.23 to 1:3. The pharmaceutical composition not only increases the bioavailability of the pharmaceutically active ingredient, but also reduces absorption variability, and provides a more stable concentration of dabigatran in plasma, thereby reducing adverse side effects.Type: ApplicationFiled: November 27, 2018Publication date: December 2, 2021Applicant: SHANGHAI WD PHARMACEUTICAL CO., LTDInventors: Liang Chang DONG, Shizhong ZHANG, Yan JIAO, Danyong ZHANG, Wenfang ZHAO, Jingmin SHI
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Publication number: 20210169811Abstract: Disclosed are a controlled-release dosage form with an absorption window in the upper gastrointestinal tract and a preparation method therefor, wherein the controlled-release dosage form comprises a controlled-release platform and a retention platform. The controlled-release platform is a pharmaceutical composition comprising a tablet core and a coating membrane; and the retention platform holds the controlled-release platform in the oral cavity. The operation steps of the controlled-release dosage form are as follows: placing the controlled-release platform in the retention platform, and fixing the retention platform on matching teeth in the oral cavity; taking out the controlled-release dosage form after 4-24 hours and replacing same with a new controlled-release platform; and re-fixing the retention platform on the matching teeth in the oral cavity to achieve the sustained and stable release of drugs.Type: ApplicationFiled: November 23, 2020Publication date: June 10, 2021Applicant: SHANGHAI WD PHARMACEUTICAL CO., LTDInventors: Liang Chang DONG, Xishan CHEN, Jingmin SHI, Danyong ZHANG, Gang WU
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Publication number: 20210015737Abstract: Disclosed are a pharmaceutical composition, an osmotic pump controlled-release drug delivery system comprising the pharmaceutical composition and a preparation method therefor. The pharmaceutical composition comprises a tablet core and a coating film. The tablet core comprises a drug-pulling layer, and the coating film comprises 50-90 wt % of cellulose acetate and 10-50 wt % of Copovidone. The Copovidone can be obtained by means of the polymerization of vinyl pyrrolidone and vinyl acetate in a molar ratio of 40:60-80:20.Type: ApplicationFiled: February 28, 2019Publication date: January 21, 2021Applicant: SHANGHAI WD PHARMACEUTICAL CO., LTDInventors: Liang Chang DONG, Xishan CHEN
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Publication number: 20200368221Abstract: A solid particle, a preparation method therefor, and a pharmaceutical composition. The solid particle comprises a porous solid particle and a non-aqueous liquid formula. The non-aqueous liquid formula comprises 0.10-4.00 wt % of a hydrophobic active pharmaceutical agent, 28.00-99.90 wt % of a hydrophobic solubilizing solution, 0-70.00 wt % of a non-ionic surfactant, and 0-1.00 wt % of an antioxidant. The hydrophobic solubilizing solution comprises a medium-chain monoglyceride and diglyceride, and/or a propylene glycol fatty acid monoester.Type: ApplicationFiled: November 27, 2018Publication date: November 26, 2020Applicant: SHANGHAI WD PHARMACEUTICAL CO., LTDInventors: Liang Chang DONG, Wenbo MA, Lin WANG