Patents Assigned to Shanhai Hua Yi Bio-Tech Lab
  • Patent number: 7544512
    Abstract: The present invention discloses a method of producing polypeptides, including insulinotropic GLP-1 (7-36) polypeptide and/or GLP-1 analogs, by ligating genes in a tandem way. Also disclosed are the recombinant polypeptides produced by such a method. Using the method of this invention, 1 to 32 copies of GLP-1 (7-36) and/or GLP-1 analog genes may be expressed in tandem and the desired polypeptide can be obtained after cleavage of a fusion protein and further processes of separation and purification thus making possible the production of recombinant polypeptides, including recombinant GLP-1 (7-36) and/or GLP-1 analogs on a large scale, at a significantly reduced production cost.
    Type: Grant
    Filed: January 20, 2004
    Date of Patent: June 9, 2009
    Assignee: Shanhai Hua Yi Bio-Tech Lab
    Inventors: Yukun Sun, Dengxi Wu, Aizhen Wu, Zhiyong Zhu, Gang Yu, Jiaxiang Zhou, Shaoling Zhao