Abstract: The present disclosure relates to a grouting material for reinforcement of coal-rock mass in low-temperature mining. The material includes a component A and a component B, where the component A includes 100 parts of a polyether polyol A and 0.05 parts to 0.1 parts of a catalyst; the component B includes 18 parts to 24 parts of a polyether polyol B, 21 parts to 26 parts of a flame retardant, 50 parts to 61 parts of polyisocyanate, and 0.05 parts of the catalyst. A preparation method of the grouting material includes the following steps: stirring the polyether polyol A and the catalyst to obtain the component A; drying the polyether polyol B and mixing with the polyisocyanate and the catalyst, and conducting a reaction to obtain an isocyanate prepolymer; adding the flame retardant to the isocyanate prepolymer, and adjusting a viscosity to obtain the component B.