Abstract: Described herein are polynucleotide constructs and stable cell lines for inducible production of rAAV virions within which are packaged a payload polynucleotide.
Abstract: Disclosed herein are compositions that comprise engineered polynucleotides, pharmaceutical compositions comprising the same, methods of making the same, and methods of treatment comprising the compositions that comprise the engineered polynucleotides.
Type:
Grant
Filed:
December 1, 2020
Date of Patent:
November 28, 2023
Assignee:
Shape Therapeutics Inc.
Inventors:
David Huss, Prashant Mali, Anupama Lakshmanan, Christopher Nye, Yiannis Savva, Liana Stein, Richard Sullivan, Rafael Ponce, Susan Byrne