Patent number: 11466047
Abstract: A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
Type:
Grant
Filed:
May 7, 2018
Date of Patent:
October 11, 2022
Assignee:
Merck Sharp & Dohme LLC
Inventors:
Wen-Lian Wu, Jongwon Lim, Jared N. Cumming, Benjamin Wesley Trotter, Wonsuk Chang