Abstract: The present invention relates to Tetracyclic Heterocycle Compounds of Formula and pharmaceutically acceptable salts or prodrug thereof, wherein A, X, R1, R2, R3 and Ware as defined herein. The present invention also relates to compositions comprising at least one Tetracyclic Heterocycle Compound, and methods of using the Tetracyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.
Type:
Grant
Filed:
September 18, 2020
Date of Patent:
June 14, 2022
Assignee:
Merck Sharp & Dohme Corp.
Inventors:
Thomas H. Graham, Tao Yu, Yonglian Zhang, John A. McCauley
Abstract: Provided is a coding unit to determine the number of code block groups, divide an input bit sequence to code block segmentation into code block groups of the number of the code block groups, determine the number of code blocks for each of the code block groups, divide each of the code block groups into code blocks of the number of the code blocks, and apply channel coding to each of the code blocks.
Type:
Grant
Filed:
July 7, 2017
Date of Patent:
June 14, 2022
Assignees:
FG Innovation Company Limited, Sharp Kabushiki Kaisha
Abstract: A terminal apparatus determines the parameter fc(i), based on at least whether an RRC layer parameter symPUSCH_UpPTS is configured for the terminal apparatus, calculates transmit power for PUSCH transmission in a subframe i, based on at least the parameter fc(i), maps a PUSCH to a SC-FDMA symbol of a special subframe, based on the RRC layer parameter symPUSCH_UpPTS, and transmits the PUSCH.
Type:
Grant
Filed:
September 6, 2018
Date of Patent:
June 14, 2022
Assignees:
SHARP KABUSHIKI KAISHA, FG Innovation Company Limited
Abstract: A terminal apparatus receives first information for identifying one or multiple random access channel occasions, and receives second information for identifying an index of a random access preamble. In a case that a first condition is satisfied, the terminal apparatus selects, from one or multiple reference signals, one reference signal based on a measurement of each of the one or multiple reference signals. In a case that a second condition is satisfied, the terminal apparatus selects one reference signal of the one or multiple reference signals associated with a PDCCH used to receive the second information. The terminal apparatus selects, from the one or multiple random access channel occasions, one random access channel occasion associated with the one reference signal selected.
Type:
Grant
Filed:
November 15, 2018
Date of Patent:
June 14, 2022
Assignees:
SHARP KABUSHIKI KAISHA, FG Innovation Company Limited
Abstract: A terminal apparatus includes a transmitter configured to transmit a UCI payload with CRC bits by using a PUCCH, wherein a size of the CRC bits added to the UCI payload is a first size, and a number of PRBs of a resource of the PUCCH is given based on a second size of the CRC bits.
Type:
Grant
Filed:
December 27, 2018
Date of Patent:
June 14, 2022
Assignees:
SHARP KABUSHIKI KAISHA, FG Innovation Company Limited
Abstract: The present invention relates to Compounds of Formula I: and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, R3, A and B are as defined herein. The present invention also relates to compositions comprising at least one compound of Formula I, and methods of using the compounds of Formula I for treating or preventing cancer, inflammation, neurodegeneration disease and/or diabetes in a subject.
Type:
Application
Filed:
March 30, 2020
Publication date:
June 9, 2022
Applicant:
Merck Sharp & Dohme Corp.
Inventors:
Jian LIU, Younong YU, Joseph A. KOZLOWSKI, Deyou SHA, Wensheng YU, Joseph M. KELLY, Scott E. WOLKENBERG
Abstract: A display device, includes: a first processor configured to increase or decrease values of color components representing three colors and included in a first video signal, in accordance with values corresponding to the values of the color components representing three colors; a second processor configured to convert a second video signal into a third video signal, the second video signal including the color components representing three colors and having the values increased or decreased by the first processor, and the third video signal including color components representing four colors; and a display configured to display the third video signal including the color components representing four colors.
Abstract: The invention relates to stable formulations of cyclic dinucleotide STING agonist compounds or pharmaceutically acceptable salts thereof. The invention further provides methods for treating various cancers with stable formulations of the invention. In some embodiments of the methods of the invention, the formulations are administered to a subject by intratumoral or subcutaneous administration.
Type:
Application
Filed:
March 24, 2020
Publication date:
June 9, 2022
Applicant:
Merck Sharp & Dohme Corp.
Inventors:
Margaret Brunell, Erin N. Guidry, Yash Kapoor, Eric A. Kemp, Ellen C. Minnihan, Sachin Mittal, Elizabeth Pierson, Mikhail Reibarkh, Tammy W. Shen, Erika R. Walsh, Paul L. Walsh
Abstract: Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.
Type:
Grant
Filed:
May 28, 2019
Date of Patent:
June 7, 2022
Assignee:
MERCK SHARP & DOHME CORP.
Inventors:
Shuwen He, Dane Clausen, Liangqin Guo, Yongxin Han, Xianhai Huang, Alexander Pasternak, Qinglin Pu, Dong Xiao, Li Xiao, Feng Ye, Hongjun Zhang
Abstract: An in-vivo camera device and an in-vivo monitoring camera system more excellent in usability are proposed. An in-vivo camera device includes a camera unit introduced into a body, a support member, and a camera-side cable. The support member has a trocar connection portion for connection with a trocar at a front end side, and is connected to the trocar in a state in which the trocar connection portion is fitted into the trocar by applying tensile force to the camera-side cable passing through the trocar. The support member is provided with a guide introduction portion that is formed to be relatively long at the front end side as a stabilization structure for stabilizing connection with the trocar.
Abstract: An image forming device includes a communicator that receives a series of image data, a timer that measures a reception time of each of the series of image data, and a storage that temporarily stores the image data received before forming an image based on the series of image data. When the communicator receives image data, and subsequently does not receive the next image data within a predetermined reception time, the controller obtains the time difference between the time of the reception end of the series of image data, and the reception time of the image data last received by the communicator, determines that the last received image data may be incomplete image data when the time difference is greater than or equal to a predetermined time, and determines whether to form an image based on the image data stored in the storage according to the determination.
Abstract: A layout pattern of a demultiplexer circuit of a display device employing the SSD method is configured as described below. Specifically, demultiplexers in the demultiplexer circuit are grouped with three demultiplexers as one set, and nine transistors as switching elements included in the three demultiplexers of each set are arranged to be aligned in the extending direction of a source line with three transistors as a unit while positions of the nine transistors are sequentially shifted in the vertical direction with respect to the source line. Furthermore, any two adjacent sets are arranged such that a direction in which nine transistors included in one set are shifted in the vertical direction with three transistors as a unit and a direction in which nine transistors in the other set are shifted in the above-described vertical direction with three transistors as a unit are opposite to each other.
Abstract: The present invention provides a method for producing a substrate with a photo-alignment film, which increases the refractive index anisotropy while reducing a decrease in production efficiency. The method for producing a substrate with a photo-alignment film includes the steps of: (A) forming on a surface of a substrate a film of a photo-alignment film material containing a polymer with a photo-functional group; (B) irradiating the film formed in the step (A) with polarized light obtained by polarizing light emitted from a light emitting diode lamp; and (C) irradiating the film having been subjected to the polarized light irradiation in the step (B) with polarized light obtained by polarizing light emitted from a metal halide lamp.
Abstract: A mobile node includes a plurality of transceivers, has a network conforming to network-based mobility as its home link and performs position registration to a positional managing apparatus and performs position registration to the position managing apparatus through a foreign network by position registration conforming to host-based mobility. In mobile node and position managing apparatus, a plurality of routes passing through the home link and the foreign link are established. Accordingly, when the mobile node has the plurality of transceivers, it can simultaneously connect to the home link and the foreign link through respective transceivers, to perform communication.
Abstract: A display device includes a light-emitting element layer including a plurality of light-emitting elements. The light-emitting element layer includes, for each of the plurality of light-emitting elements, a first electrode and a plurality of openings exposing the first electrode, and includes an edge cover covering an end portion of the first electrode, a plurality of light-emitting layers covering each of the plurality of openings, and a second electrode that is common to the plurality of light-emitting elements and covers the plurality of light-emitting layers. The second electrode includes a metal nanowire. Furthermore, the light-emitting element layer includes an auxiliary wiring line provided in a lattice pattern in a position overlapping the edge cover, and the auxiliary wiring line and the metal nanowire are electrically connected to each other.
Abstract: To provide a communication control means for establishing a session between a terminal apparatus and a network in a network-initiated manner and/or a connection control means for supporting service continuity and/or a session establishment control means for supporting service continuity and/or a communication control means for service continuity, and the like. These provide a communication control method for establishing an optimal session for service continuity through which service is continued by switching between sessions for communication, an optimal communication control method for service continuity, and the like.
Type:
Grant
Filed:
May 16, 2017
Date of Patent:
May 31, 2022
Assignees:
SHARP KABUSHIKI KAISHA, FG Innovation Company Limited
Abstract: A liquid crystal display panel includes a first substrate section having a first substrate and pixel electrodes (102). Each pixel electrode (102) includes a bridging portion (102c) provided between a first pixel electrode portion (102a) and a second pixel electrode portion (102b) and linking together the first pixel electrode portion (102a) and the second pixel electrode portion (102b). A first recess (102d) is provided at one side along the width direction of the pixel electrode (102), the first recess (102d) extending from one side along the width direction of the pixel electrode (102) toward the bridging portion (102c) and being located between the first pixel electrode portion (102a) and the second pixel electrode portion (102b).
Abstract: A method for manufacturing a scanning antenna with a plurality of antenna units arrayed therein, the scanning antenna including a TFT substrate including a first dielectric substrate, a TFT, gate bus lines, source bus lines, and a plurality of patch electrodes, a slot substrate including a second dielectric substrate and a slot electrode including a plurality of slots disposed corresponding to the plurality of patch electrodes, a liquid crystal layer, and a reflective conductive plate, includes a step (a) of depositing a first conductive film containing copper on a first main surface of the second dielectric substrate, a step (b) of, after step (a), bringing the first conductive film into contact with an atmosphere to form an oxide film on a surface of the first conductive film, and a step (c) of, after step (b), depositing a second conductive film containing copper on the oxide film.
Abstract: A liquid crystal display panel includes a first substrate, a second substrate, a liquid crystal layer, a first polarizer plate, and a second polarizer plate. The first substrate includes a first dielectric substrate, a first electrode, a second electrode, and a first alignment film. The second electrode includes a plurality of slits and a conductive portion. The second substrate includes a second dielectric substrate and a second alignment film. The first substrate further includes a resin layer disposed between the second electrode and the first alignment film. The resin layer within the plurality of slits is as thick as or thicker than the second electrode. The plurality of slits are filled with the resin layer. A difference in height between the resin layer over the conductive portion of the second electrode and the resin layer within the plurality of slits of the second electrode is 10 nm or more.
Abstract: The present invention relates to methods for producing a stable amorphous dispersion of a pharmaceutically active substance having poor water solubility by applying low frequency acoustic energy to a mixture comprising the active substance and at least one polymer and heating the mixture until a stable amorphous dispersion is formed. The methods of the invention are an effective means of converting a crystalline API to a substantially amorphous and stable form, i.e., wherein the crystallinity is less than about 5%. The methods of the invention result in more complete amorphization, increased solubility, drug loading and stability as compared typical amorphization or literature methods.
Type:
Grant
Filed:
August 20, 2018
Date of Patent:
May 31, 2022
Assignee:
Merck Sharp & Dohme Corp.
Inventors:
Dennis H. Leung, Zhiqiang Guo, Christopher W. Boyce