Abstract: Methods for improving the drying yield and stability of RSV vaccines comprising a highly thermolabile enveloped live virus and/or one or more RSV protein subunits, are described. Methods for rapid drying of RSV formulations containing between 17.5% and 60% w/w of a non-polymeric sugar and using either conduction or radiation dominant drying mechanisms, are disclosed. The disclosed methods provide for; 1) a dried RSV formulation with improved stability profile; 2) faster drying; and 3) integration of dried RSV into a primary device (such as dual chamber cartridges, foil-pouch devices etc.), pre- as well as post-drying.

Abstract: A complimentary trade drug delivery system comprising (a) an electronic health record platform for storing patient health record data and generating electronic prescriptions, and (b) an eligibility verification system for identifying and verifying eligible programs, patients and health care providers for complimentary trade drug programs. The eligibility verification system automatically verifies that patients and prescribing health care providers are eligible to participate in existing complimentary trade drug programs and sends orders to program pharmacy computer systems that cause a program pharmacy computer system to deliver complimentary trade drugs to a patient.

Abstract: Pkg resin crack is suppressed after dicing. A light emitting device 1 where a light emitting device 2 that emits light is mounted on a lead frame 3 and that uses a resin cavity molding package 5 having an integrally molded lead frames 3, 4 constituting electrodes that correspond to the light emitting element 2 and resin, wherein roundness is given to a part or all of a cutting plane corner part of a retention section (hanger lead 3a, 4a) that become a cause of crack generation due to the retention sections (hanger leads 3a, 4a) of the lead frames giving stress concentration to resin at the time of cutting by a blade 7.

Abstract: Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.

Abstract: A User Equipment (UE) for handling a type-2 carrier is described. The UE includes a processor and memory in electronic communication with the processor. The instructions stored in the memory are executable to apply a configuration with one or more serving cells including at least one type-2 secondary cell (SCell). The instructions stored in the memory are also executable to obtain a measurement for each of the one or more serving cells except for the at least one type-2 SCell. The instructions stored in the memory are further executable to set a measurement list to include the measurement for each of the one or more serving cells except for the at least one type-2 SCell. The instructions stored in the memory are additionally executable to send the measurement list.

Abstract: A mobile station (MS) decodes at least one PDCCH on at least a first downlink component carrier (DCC). The MS transmits HARQ control information for a PDSCH transmission indicated by a detection of a PDCCH and using a first PUCCH resource and a first PUCCH format, where the first PUCCH and the first PUCCH format are used for the transmission of the HARQ control information for the PDSCH transmission on the second DCC, the PDSCH transmission on the second DCC being indicated by the detection of the PDCCH. The MS also transmits the HARQ control information using a second PUCCH resource and a second PUCCH format, the second PUCCH resource and the second PUCCH format being used for the transmission of the HARQ control information for the PDSCH transmission only on the first DCC, the PDSCH transmission only on the first DCC being indicated by the detection of the PDCCH.

Abstract: A method for making a stamper which has an uneven surface pattern, in which unit structures are arranged in x and y directions at respective periods that are both shorter than the shortest wavelength of an incoming light ray, on the surface of a substrate and satisfies the following Inequality (1): ? ? ? x , y ? m ? ? i ? ? n < 1 ni + ni · sin ? ? ? ? ? i ma ? ? x ( 1 ) where ?min is the shortest wavelength of the incoming light ray, ?imax is the largest angle of incidence of the incoming light ray, ni is the refractive index of an incidence medium, ?x is the period of the uneven surface pattern in the x direction, and ?y is the period of the pattern in the y direction. As a result, diffraction of short-wave light components can be reduced in a broad wavelength range.

Abstract: A lighting film 1 includes a base member 10 which has light-transmitting properties, a plurality of protrusion portions 11 which have light-transmitting properties and are formed on one surface of the base member 10 so as to be adjacent to each other, and a gap portion 12 which is formed between the protrusion portions. In the protrusion portion 11, a first end surface 11a on the base member 10 side or a second end surface 11b on an opposite side to the base member 10 is configured as a light incidence end surface, and a side surface 11c which comes into contact with the gap portion 12 is configured as a reflective surface of totally reflecting light which is incident from the light incidence end surface. The base member 10 or a member that is formed on one surface of the base member 10 and has light-transmitting properties is exposed in the gap portion 12.

Abstract: In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (I): (I) and include stereoisomers thereof, and pharmaceutically acceptable salts of said compounds stereoisomers, wherein each of R1, R2, R3, R4, R5, R9, ring A, ring B, m, n, p, -L1-, L2-, and L3- is selected independently and as defined herein. The novel iminothiadiazine dioxide compounds of the invention have surprisingly been found to exhibit properties which are expected to render them advantageous as BACE inhibitors and/or for the treatment and prevention of various pathologies related to ?-amyloid (A?) production. Pharmaceutical compositions comprising one or more such compounds (alone and in combination nation with one or more other active agents), and methods for their preparation and use in treating pathologies associated with amyloid beta (A?) protein, including Alzheimers disease, are also disclosed.

Abstract: In its many embodiments, the present invention provides provides certain S-imino-S-oxo iminothiadiazine compounds, including compounds Formula (I): or a tautomers and/or stereoisomers thereof, and pharmaceutically acceptable salts of said compounds, said tautomeros and said stereoisomers, wherein RN, R1, R2, R3, R4, ring A, RA, m, L1, and RL are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and may be useful for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including for the possible treatment of Alzheimer's disease, are also disclosed.

Abstract: Methods for increasing the yield and N-glycosylation site occupancy of paucimannose or complex N-glycans of recombinant glycoproteins produced in a recombinant host cell lacking dolichyl-P-Man:Man5GlcNAc2-PP-dolichyl alpha-1,3 mannosyltransferase (Alg3p) activity are disclosed. In particular, recombinant host cells are provided that comprise a disruption of the expression of an OS-9 family gene in the host cell. These recombinant host cells may then be used for producing recombinant glycoproteins. In further embodiments, the recombinant host cells further overexpress at least one heterologous single-subunit oligosaccharyltransferase, which in particular embodiments is capable of functionally suppressing the lethal phenotype of a mutation of at least one essential protein of the yeast oligosaccharyltransferase (OTase) complex.

Abstract: A method is provided for fabricating an antimony anode. The method disperses antimony (Sb) particles in a layered carbon network using a process such as mechanical mixing, ball milling, stirring, or ultrasound sonication, forming a Sb/carbon composite. The Sb/carbon composite is mixed with a binder, forming a mixture, and the mixture is deposited on a current collector. Advantageously, the binder may be an aqueous (water soluble) binder. In one aspect, prior to dispersing the Sb particles in the layered carbon network, the Sb particles are coated with carbon. For example, the Sb particles may be dispersed in a solution including a polymer, where the solution may be an aqueous or organic. Alternatively, the Sb particles may be dispersed in a solution including a monomer. The monomer solution is polymerized to form polymer sheathed Sb core-shell structures, and then carbonized. Associated Sb anodes and Sb anode batteries are also provided.

Abstract: When an optical element is produced by sandwiching a resin between a pair of molds, the resin is cured while a mold is kept in contact with the resin until the temperature of the resin reaches a gel point. Throughout the process, a load cell monitors pressure exerted to the mold. After detection of a state in which the pressure exerted to the mold is a negative pressure, the resin is cured while the position of the mold is controlled so that the pressure exerted to the mold is increased to a predetermined positive pressure and thereafter the positive pressure is maintained.

Abstract: Zero-voltage switching of a switching element (Q2) is achieved by turning off a switching element (Q1) and then turning on switching element (Q2) while the parasitic diode (DQ2) of switching element (Q2) is turned on. Subsequently, switching element (Q2) is turned off when the current flowing through switching element (Q2) changes from negative to positive (in a direction from the drain towards the source) and the current reaches a prescribed threshold value. Then, zero-voltage switching of switching element (Q1) is achieved by turning on switching element (Q1) while the parasitic diode (DQ1) of switching element (Q1) is turned on.

Abstract: Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein the saccharide for at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.

Abstract: Provided are a terminal apparatus, a base station apparatus, a communication apparatus, a cell selection method, and an integrated circuit in which a cell selection procedure between the mobile station apparatus and the base station apparatus are efficiently performed to improve communication quality. The terminal apparatus determines whether or not a cell detected by the terminal apparatus is suitable for a cell selection candidate on the basis of first cell restriction information indicating cell access restriction that is applied during cell selection, second cell restriction information that is determined by the terminal apparatus whether or not to apply, and a cell measurement result.

Abstract: There is realized a display device capable of compensating for a deterioration of a circuit element while suppressing an increase of a circuit scale. One horizontal scanning period for a monitor row is composed of: a detection preparation period where preparation for detecting TFT characteristics and OLED characteristics is performed in the monitor row; a TFT characteristic detection period where current measurement for detecting the TFT characteristics is performed; an OLED characteristic detection period where current measurement for detecting the OLED characteristics is performed; and a light emission preparation period where preparation for allowing an organic EL element to emit light is performed in the monitor row. Data lines are used not only as signal lines that transfer a signal for allowing an organic EL element in each pixel circuit to emit light at desired brightness, but also as characteristic detecting signal lines.

Abstract: A smartphone includes: an image display section for displaying images in such a manner as to be selectable by a user, each of the images being associated with (i) specifying information for specifying a cleaning robot and (ii) instruction information for instructing the cleaning robot to execute a predetermined process; and a process instruction section for transmitting, in a case where the user selects at least one of the images thus displayed, image information (2) indicative of said at least one of the images to a server, so as to cause the cleaning robot specified by specifying information associated with said at least one of the images to execute a predetermined process that is instructed by instruction information associated with said at least one of the images.

Abstract: When a position detecting section detects two points of contact with a display screen of a display section, a medium deciding section decides a recording medium based on a change in distance between the two points. And an image displayed on the display section is formed on the recording medium decided on by the medium deciding section.