Abstract: Disclosed herein are substituted pyrazole-pyrimidine compounds of Formula I and variants thereof for the treatment, for example, of diseases associated with P2X purinergic receptors: In one embodiment, the P2X3 and/or P2X2/3 antagonists disclosed herein are potentially useful, for example, for the treatment of visceral organ, cardiovascular and pain-related diseases, conditions and disorders.

Abstract: This disclosure relates to stable aqueous pharmaceutical formulations comprising a therapeutically effective amount of an incretin-insulin conjugate as well as methods of using the same, and aqueous pharmaceutical formulations containing an incretin-insulin conjugate which are stable and which provide a protracted pharmacodynamics profile, which include L-arginine HCl and phenol (or m-cresol) as stabilizing agents. The invention also provide a method of treating a patient or individual having a metabolic disease, comprising administering to the patient or individual an effective amount of any of the aqueous pharmaceutical formulations described herein.

Abstract: The present invention provides a communication means that enables use of a function for providing connectivity to a local area data network (LADN) in a 5G system (5GS). Furthermore, the present invention provides a communication means that enables use of a function for providing connectivity to an LADN between a user equipment and a network when the use of the function for providing connectivity to an LADN is enabled.

Abstract: A wide field of view display device employs curved optical components for enhanced performance with a compact arrangement. A wide field of view display includes a curved display device; a first curved lens having a display side and an exit side, wherein the display side is facing the curved display device; a first plurality of Fresnel facets disposed on the display side of the first curved lens; a second curved lens having a display side and an exit side, wherein the display side is facing the exit side of the first curved lens; and a second plurality of Fresnel facets disposed on the display side of the second curved lens, wherein the first plurality of Fresnel facets is configured to focus light from the curved display device on the second plurality of Fresnel facets, and wherein the second plurality of Fresnel facets is configured to focus light from the first plurality of Fresnel facets on a central image point.

Abstract: A display device includes a light-emitting element layer including light-emitting elements in a plurality of kinds each emitting a light in a different color. A first electrode of the light-emitting elements includes a plurality of reflective layers including one RM and one TE stacked on the RM. The plurality of the reflective layers are stacked so that the RM and the TE are alternatively arranged in the stated order.

Abstract: A handheld, battery operated device that, when activated, will grip a screw-cap on the top of a cryogenic vial, microtube, test tube or other pharmaceutical product container, and automatically rotate the cap in a counterclockwise direction to remove the cap, and automatically rotate the cap in a clockwise direction to fasten the cap back on the cryogenic vial, microtube, test tube or other pharmaceutical product container.

Abstract: The present invention relates to novel Bicyclic Heterocycle Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, X, Y, Z, R1 R5, R6, and R7 are as defined herein. The present invention also relates to compositions comprising at least one Bicyclic Heterocycle Compound, and methods of using the Bicyclic Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.

Abstract: In its many embodiments, the present invention provides certain 7-, 8-, and 10-substituted amino triazolo quinazoline derivatives of Formula (I): or a pharmaceutically acceptable salt thereof, wherein ring A, R1, R2, and R4 are as defined herein, pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other therapeutic agents), and methods for their preparation and use, alone and in combination with other therapeutic agents, as antagonists of A2a and/or A2b receptors, and their use in the treatment of a variety of diseases, conditions, or disorders that are mediated, at least in part, by the adenosine A2a receptor and/or the adenosine A2b receptor.

Abstract: Provided herein are methods of treating cancer (e.g., RCC), which comprise administering to a human patient in need thereof: (a) a PD-1 antagonist; (b) an ILT4 antagonist; and (c) lenvatinib represented by Formula (I), or a pharmaceutically acceptable salt thereof. Also provided are kits containing such agents and uses of therapeutic combinations of such agents for the treatment of cancer.

Abstract: A conduction mechanism includes: a conductive bearing that rotatably supports a rotary shaft; a non-conductive axial positioner that has a cylinder externally fitted to the bearing; and a contact terminal attached to an outer circumferential surface side of the cylinder. The cylinder has a slit, and the contact terminal has an abutment piece that is exposed to an inner circumferential surface side of the cylinder from the slit and abuts an outer circumferential surface of the bearing.

Abstract: A multi-function peripheral as an image processing device according to the present invention is wirelessly connected with a mobile terminal having a display and is capable of accepting an operation by a user via the mobile terminal. For this, a terminal side setting screen for operating the multi-function peripheral is displayed on the display of the mobile terminal. The terminal side setting screen includes buttons for an operation requiring the user to be in the vicinity of the multi-function peripheral. These buttons are brought in a mode capable of accepting the operation, when an estimated distance between the multi-function peripheral and the mobile terminal is less than or equal to a threshold value, whereas are brought in a mode incapable of accepting the operation, when the estimated distance exceeds the threshold value.

Abstract: A fixing device includes an endless fixing belt capable of rotational movement, a pressure roller that presses from the outside of the fixing belt, a nip forming member that is arranged on an inner circumference surface side of the fixing belt and forms a fixing nip region between the fixing belt and the pressure roller, a support member that supports the nip forming member from an opposite side to the fixing nip region, and a slide sheet provided between the fixing belt and the nip forming member. The support member includes two support portions. The slide sheet is fixed between the two support portions.

Abstract: A display system includes: a transmission device that transmits image data; a reception device that is connected to the transmission device and receives the image data; and a display device that displays an image indicated by the image data received by the reception device. The reception device creates a connection code, creates a security key, which is used for connection with the transmission device, from the connection code, and transmits the connection code to the display device to cause the display device to display it. The display device displays the connection code. The transmission device creates the security key from the connection code having been inputted, and is connected to the reception device by using the security key.

Abstract: An analysis device includes an electron emission element, a collector, an electric field former, a power source, and a controller. The electron emission element includes a bottom electrode, a surface electrode, and an intermediate layer arranged between the bottom electrode and the surface electrode. The power source and the controller allow application of a voltage between the bottom electrode and the surface electrode. The electric field former forms an electric field in an ion movement region where anions directly or indirectly generated by electrons emitted from the electron emission element move toward the collector. The collector and the controller allow measurement of a current waveform of an electric current made to flow by arrival of anions at the collector. The controller regulates, based on the current waveform, a voltage applied between the bottom electrode and the surface electrode.

Abstract: Disclosed herein is a novel process for preparing Compound A free base, 5-((2,4-diaminopyrimidin-5-yl)oxy)-4-iso-propyl-2-methoxybenzenesulfonamide, and a citrate salt of Compound A with simplified chemistry and a high overall yield: Compound A. In one embodiment, the overall yield from the starting material 2-isopropylphenol to Compound A citrate salt is greater than 50%. In another embodiment, the overall yield is greater than 60%. Also disclosed herein are novel salts and solvates of Compound A.

Abstract: Aspects of the present disclosure provide methods for determining the eligibility of a subject having a malignancy for treatment with an anti-PD therapeutic agent based on a Combined Positive Score (CPS) for a tumor tissue sample from the subject. Compositions and kits or performing the disclosed methods are also provided.

Abstract: An image processing device includes an image reader that reads an image, a first determiner that determines whether character crushing occurs when the image is binarized, a second determiner that determines a rate of a photographic region in the image, and a controller that performs conversion into monochrome N-gradation image data based on determination results of the first and second determiners.

Abstract: A photoelectric conversion device includes: a first carrier transport layer; a photoelectric conversion layer containing an ionic crystalline compound; and a polysiloxane layer between the first carrier transport layer and the photoelectric conversion layer, the polysiloxane layer containing a polysiloxane having a polar functional group R1.

Abstract: A method of signaling tile set parameters is disclosed. A value for a syntax element is signaled in a network abstraction layer (NAL) unit. The value for the syntax element indicates that a tile set layer syntax structure is included in the NAL unit. Values for one or more tile set parameters included in the tile set layer syntax structure are signaled.

Abstract: An active matrix substrate includes a glass substrate 26, a plurality of pixel electrodes 40 arrayed in a matrix, a plurality of TFTs 43, a plurality of common electrodes 42, a terminal group 60 provided at one end of a Y-axis direction on top of the glass substrate 26 and constituted by a plurality of terminals 61 and 62 placed along an X-axis direction, wires 71 that electrically connect the terminals 61 to the TFTs 43, and wires 72 that electrically connect the terminals 62 to the common electrodes 42.