Abstract: The invention related to an implant comprising a scaffold comprising at least one first area characterized by micropores and at least one second area characterized by macropores, wherein said at least one second area is defined by being expected to be exposed to higher pressures and/or forces when compared with said at least one first area, and methods thereof.

Abstract: A biological 3D printed multilayered scaffold is provided, which comprises a crosslinked native or non-modified protein containing a di-tyrosine matrix: the scaffold being configured for containing living cells introduced thereto during printing or post-printing.

Abstract: There is provided a method of reconstruction of a target brain structure(s), comprising: reconstructing at least a part of a brain comprising boundaries of brain structures that include the target brain structure(s), wherein the reconstruction is insufficient for parceling of the target brain structure(s) into sub-structures of a same type of gray or white matter, reconstructing and parceling the target brain structure(s) using a reference atlas, segmenting and parceling at least one originating brain structure using the reference atlas, filtering white matter fibers to isolate at least one target white matter tract connecting the originating brain structure(s) and the target brain structure(s), and creating a 3D reconstruction of the target brain structure(s) and the target white matter tract(s), wherein the target white matter tract(s) and the target brain structure(s) are transformed and/or mapped to an anatomical native space.

Abstract: A medical diagnostic device may include: an annular body having a proximal end, a distal end, a central longitudinal axis and a hollow interior, and wherein the distal end is configured to be inserted into a bodily orifice of a subject; a base connected to the proximal end of the annular body adapted to be held by hand of the subject and having a hollow interior; a first imaging device insertable at the distal end of the annular body, wherein the first imaging device is configured to obtain one or more images of an internal environment of the bodily orifice of the subject; and a second imaging device insertable into the hollow interior of the base, wherein the second imaging device is configured to obtain one or more images of an external environment of the bodily orifice of the subject.

Abstract: The invention provides assays and methods for analyzing inflammatory disorders of the gastrointestinal (GI) tract. Provided in embodiments of the invention are host transcriptome markers and classifiers amenable for assessing and monitoring the existence, severity and location of inflammation associated with inflammatory bowel disease (IBD), Crohn's disease (CD) and Ulcerative colitis (UC). Further provided are improved protocols for processing and analyzing fecal samples, providing superior non-invasive means for evaluating GI inflammation.

Abstract: Disclosed herein are receive-only network devices and methods for use for securely identifying a network. The receive-only network device comprised a network physical layer (PHY) circuit configured to establish a physical layer connection to a network via one or more wired transmission mediums and a controller electrically coupled to a receive channel of the PHY via a unidirectional hardware buffer configured to transfer electronic signals received from the PHY and block electronic signals received from the controller. The controller is configured to receive from the PHY one or more link layer frames transmitted by one or more network controllers of the network and intercepted by the PHY, extract one or more network attributes of the network from the one or more intercepted link layer frames, identify the network at least partially according to the one or more extracted network attributes, and present the identity of the network to a user.

Abstract: Apparatus and methods are described for use with an annuloplasty ring (20), and an atrioventricular valve of a heart of a mammalian subject, the atrioventricular valve including a valve annulus, valve leaflets, chords, and papillary muscles. A plurality of chord-manipulation arms (26) are configured to be deployed among the chords of the atrioventricular valve, and to cause a size of the valve annulus to decrease, by the chord-manipulation arms (26) being rotated such as to twist the native atrioventricular valve and pull the native atrioventricular valve radially inwards, by the chord-manipulation arms (26) deflecting the chords. The chord-manipulation arms (26) are configured to subsequently provide a counterforce against which the annuloplasty ring (20) is pushed, during implantation of the annuloplasty ring (20). Other applications are also described.

Abstract: The present invention provides methods and compositions comprising essential oil extracted from Pelargonium graveolens for treating, preventing, or ameliorating traumatic brain injury (TBI) in a subject, or for improving cognitive functions in a subject suffering from TBI.

Abstract: Apparatus and methods are described herein including an expandable prosthetic mitral valve device that includes a first component configured to be deployed in a left atrium of the subject and a second component configured to be deployed in a left ventricle of the subject. At least one approximating component approximates the first and second components with respect to each other, such that, when the first and said second components are in an approximated configuration with respect to each other, one or more leaflets of the native mitral valve are trapped within the gap between a ventricular part and an annulus part. The approximating component secures the annulus part and the ventricular part in the approximated configuration. Other applications are also described.

Abstract: A system for monitoring treatment of a patient includes data input and output utilities, memory, and a data processor, and communicates with an image data provider to receive therefrom image data indicative of combined PET-CT scan images including at least one first and at least one second pre-treatment full body scan image of a patient. The data processor includes an identifier utility that processes the image data to identify matching first and second 2D regions in, respectively, first 2D slices forming the first scan image and second 2D slices forming the second scan image, and locate at least one pair of corresponding first and second 3D regions in the scan images; and an analyzer that analyzes each pair of the first and second 3D regions and determine a change in at least one parameter in the first and second 3D regions, and generate output data indicative of said change.

Abstract: A method of diagnosing pancreatic cancer in a subject in need thereof is provided. The method comprising determining a level of at least syndecan 1 (SDC1) in a blood sample or a fraction thereof of the subject, wherein when the level of SDC1 is above a predetermined threshold, the subject is diagnosed with pancreatic cancer.

Abstract: A method of determining a condition of a subject comprises receiving functional magnetic resonance (MR) data and structural MR data, each describing the brain of the subject. A subject-specific functional connectome (FC) is constructed using the functional MR data, and a subject-specific structural connectome (SC) is constructed using the structural MR data. A convolutional neural network (CNN) is fed with the subject-specific FC and SC. The CNN has a first set of layers that separately process the subject-specific FC and SC, and a second set of layers that process combined outputs from the first set of layers. An output indicative of the condition of the subject is received from the second set of layers of the CNN.

Abstract: A method of treating an infection of a gram positive bacteria in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of enterobactin and/or an active derivative thereof. Compositions comprising enterobactin are also disclosed or active derivatives are also disclosed.

Abstract: A method of treating an infection of a gram positive bacteria in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of enterobactin and/or an active derivative thereof. Compositions comprising enterobactin are also disclosed or active derivatives are also disclosed.

Abstract: A method of analyzing an abdominal computed tomography (CT) scan comprises applying a colon segmentation machine learning procedure to the CT scan, and receiving from the colon segmentation machine learning procedure an output indicative of a plurality of colon segments. The method also comprises feeding the output into a colon lesion detection machine learning procedure, and receiving from the colon lesion detection machine learning procedure an output indicative of presence of at least one pathology in the colon.

Abstract: There is provided a method for reconstructing a 3D image, comprising: obtaining Doppler ultrasound images depicting a blood vessel and measurement of blood flow in the blood vessel, and 2D camera images captured by a camera depicting fiducial objects randomly distributed within a viscous material and spaced apart by random distances on a surface of the individual, computing 3D coordinates within a world coordinate system for pixels of the Doppler images using an external reference of an ultrasound transducer pose computed by analysis of relative changes in locations of the fiducial objects within sequential camera images, and computing a respective estimated blood flow for pixels of the Doppler images at locations within the blood vessel, reconstructing a 3D image from 3D voxels computed from the 3D coordinates of pixels of the Doppler images, including respective estimated blood flow, wherein the 3D image depicts the blood vessel and blood flow.

Abstract: A method of implementing an extended reality (XR) neuropsychological test of a person, including projecting onto an immersive display configured to display to the person three-dimensionally a series of virtual objects and conducting a cognitive test measuring executive functions using the virtual objects; simultaneously commanding sensors to monitor motor skills including at least one of: (i) gross hand movement by commanding a motion sensor, (ii) head movement by commanding a motion sensor, (iii) an eye movement of the person by commanding eye tracking, (iv) a gait by commanding at least one of mobility sensors, motion capture system sensors, force plate sensors or insole sensors and (v) postural stability by commanding at least one of mobility sensors, force plate sensors and insole sensors, and integrating the signals from the sensors so as to determine a neurocognitive and/or motor level of the person and produce output. Affect may also be measured.

Abstract: A method of analyzing CT data comprises receiving data describing a pre-contrast administration CT scan from a body region of the subject, and a post-contrast administration CT scan acquired from the body region at least 1 minute after initiation of administration of a contrast agent to the subject. A subtraction map is formed by subtracting one of the scans from another. The subtraction map is displayed in a manner that identifies leaking of contrast agent out of blood vessels in the region.