Patents Assigned to SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD.
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Patent number: 11976063Abstract: The invention provides various novel compositions of berberine in combination with pharmacologically active organic acids, and related methods of their use in treating various diseases or disorders. The invention further provides various novel compounds prepared from berberine and pharmacologically active organic acids and prepared from ursodeoxycholic acid and pharmacologically active organic bases, and pharmaceutical compositions thereof, and methods of their preparation and therapeutic use in treating and/or preventing various diseases or disorders.Type: GrantFiled: February 21, 2023Date of Patent: May 7, 2024Assignee: Shenzhen HighTide Biopharmaceutical, Ltd.Inventor: Liping Liu
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Patent number: 11883539Abstract: The invention provides various novel compositions of berberine in combination with pharmacologically active EPA and DHA, and related methods of their use in treating various diseases or disorders. The pharmaceutical compositions of the invention are useful in treating and/or preventing various diseases or disorders, including metabolic diseases or disorders such as dyslipidemia, hyperglycemia, hypertriglyceridemia, hyperlipidemia, diabetic dyslipidemia, diabetic hyperlipidemia, dyslipidemia in statin-intolerance patients, diabetes, diabetic complications, hypercholesterolemia, or obesity. Additionally, the pharmaceutical compositions of the invention are useful in treating and/or preventing atherosclerosis, heart diseases, neurodegenerative diseases, inflammation, cancers, as well as various liver diseases or disorders, such as fatty liver, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, cholestatic liver diseases or graft-versus-host disease of the liver.Type: GrantFiled: May 15, 2022Date of Patent: January 30, 2024Assignee: Shenzhen HighTide Biopharmaceutical, Ltd.Inventor: Liping Liu
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Patent number: 11865106Abstract: The invention provides novel pharmaceutical compositions of berberine or a derivative or analog of berberine, or a salt thereof, in combination with one or more omega-3 fatty acids or esters thereof, and methods of their use in treating inflammatory bowel disease.Type: GrantFiled: August 8, 2018Date of Patent: January 9, 2024Assignee: SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD.Inventor: Liping Liu
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Patent number: 11807672Abstract: The invention provides novel compounds, in particular peptide and peptide analogs, which exhibit functionalities useful for treating a variety of diseases and conditions, particularly diseases and conditions relating to diabetes. The compounds of the invention are also useful for treating impaired pancreatic function, treating metabolic diseases, ex vivo islet induction, expansion and proliferation for transplantation, increasing the survival of transplanted islets in vivo, promoting neuroprotection or nerve regeneration, promoting liver regeneration, and inhibiting inflammation.Type: GrantFiled: October 4, 2020Date of Patent: November 7, 2023Assignee: Shenzhen HighTide Biopharmaceutical, Ltd.Inventors: Liping Liu, Ru Bai
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Patent number: 11685735Abstract: The invention provides various novel compositions of berberine in combination with pharmacologically active organic acids, and related methods of their use in treating various diseases or disorders. The invention further provides various novel compounds prepared from berberine and pharmacologically active organic acids and prepared from ursodeoxycholic acid and pharmacologically active organic bases, and pharmaceutical compositions thereof, and methods of their preparation and therapeutic use in treating and/or preventing various diseases or disorders.Type: GrantFiled: March 17, 2021Date of Patent: June 27, 2023Assignee: Shenzhen HighTide Biopharmaceutical, Ltd.Inventor: Liping Liu
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Patent number: 11559531Abstract: The invention provides liquid formulation compositions and medicament delivery devices, and methods for preparing and using the same. For example, the liquid formulation composition is an emulsion including a solvent and liquid particles, which includes surfactants and are dispersed in the solvent. The volume average particle size of the liquid particles is less than about 100 ?m; the surface tension of the liquid formulation composition is less than about 60 mN/m; and the absolute value of zeta potential is greater than about 15 mV. The containment vessel may be a sprayer or a dropping device. The invention also provides methods for preparation of the liquid formulation compositions and medicament delivery devices as well as methods for using the same in treatment of various diseases and condition, for example, otitis media, otitis externa, rhinitis, sinusitis, lower respiratory tract inflammation, xerostomia (dry mouth), xerophthalmia (dry eyes) and xeromycteria (dry nose).Type: GrantFiled: July 10, 2021Date of Patent: January 24, 2023Assignee: Shenzhen HighTide Biopharmaceutical, Ltd.Inventors: Li Yu, James Gerry Ferguson
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Patent number: 11534477Abstract: This invention discloses certain methods of treating acute pancreatitis and inflammatory pancreatic disease or condition. The disclosed peptides and analogs can significantly lower the elevated blood amylase and lipase levels caused by acute pancreatitis and pancreatic inflammation, reduce the degree of injury observed in pancreatic histopathology caused by pancreatitis, and significantly lower the mortality rate of acute pancreatitis.Type: GrantFiled: September 3, 2020Date of Patent: December 27, 2022Assignee: SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD.Inventors: Liping Liu, Ru Bai
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Patent number: 11369573Abstract: The invention provides various novel compositions of berberine in combination with pharmacologically active EPA and DHA, and related methods of their use in treating various diseases or disorders. The pharmaceutical compositions of the invention are useful in treating and/or preventing various diseases or disorders, including metabolic diseases or disorders such as dyslipidemia, hyperglycemia, hypertriglyceridemia, hyperlipidemia, diabetic dyslipidemia, diabetic hyperlipidemia, dyslipidemia in statin-intolerance patients, diabetes, diabetic complications, hypercholesterolemia, or obesity. Additionally, the pharmaceutical compositions of the invention are useful in treating and/or preventing atherosclerosis, heart diseases, neurodegenerative diseases, inflammation, cancers, as well as various liver diseases or disorders, such as fatty liver, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, cholestatic liver diseases or graft-versus-host disease of the liver.Type: GrantFiled: April 24, 2020Date of Patent: June 28, 2022Assignee: Shenzhen HighTide Biopharmaceutical, Ltd.Inventor: Liping Liu
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Patent number: 10988471Abstract: The invention provides various novel compositions of berberine in combination with pharmacologically active organic acids, and related methods of their use in treating various diseases or disorders. The invention further provides various novel compounds prepared from berberine and pharmacologically active organic acids and prepared from ursodeoxycholic acid and pharmacologically active organic bases, and pharmaceutical compositions thereof, and methods of their preparation and therapeutic use in treating and/or preventing various diseases or disorders.Type: GrantFiled: March 13, 2019Date of Patent: April 27, 2021Assignee: Shenzhen HighTide Biopharmaceutical, Ltd.Inventor: Liping Liu
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Patent number: 10959999Abstract: The invention generally relates to solid forms of berberine ursodeoxycholate, and to pharmaceutical compositions, and methods of preparation and therapeutic use thereof. In particular, the invention relates to solid forms of berberine ursodeoxycholate and pharmaceutical compositions thereof useful in treating and/or preventing various diseases or disorders, including metabolic disorders, heart diseases, neurodegenerative diseases and liver diseases.Type: GrantFiled: May 11, 2018Date of Patent: March 30, 2021Assignee: Shenzhen HighTide Biopharmaceutical, Ltd.Inventors: Meng Yu, Liping Liu, Xinxiang Fu
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Patent number: 10899815Abstract: The invention provides peptides and analogs of INGAP and HIP peptides. The peptides and analogs can be used in methods for treating various diseases and conditions. Such diseases and conditions can include impaired pancreatic function, treating a metabolic disease, for example, diabetes, both type 1 and type 2 diabetes, islets induction, expansion and proliferation for transplantation, promoting neuroprotection or nerve regeneration, promoting liver regeneration or inhibiting inflammation.Type: GrantFiled: May 29, 2018Date of Patent: January 26, 2021Assignee: Shenzhen HighTide Biopharmaceutical, Ltd.Inventors: Liping Liu, Ru Bai
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Patent number: 10829527Abstract: The invention provides novel compounds, in particular peptide and peptide analogs, which exhibit functionalities useful for treating a variety of diseases and conditions, particularly diseases and conditions relating to diabetes. The compounds of the invention are also useful for treating impaired pancreatic function, treating metabolic diseases, ex vivo islet induction, expansion and proliferation for transplantation, increasing the survival of transplanted islets in vivo, promoting neuroprotection or nerve regeneration, promoting liver regeneration, and inhibiting inflammation.Type: GrantFiled: March 9, 2017Date of Patent: November 10, 2020Assignee: Shenzhen HighTide Biopharmaceutical, Ltd.Inventors: Liping Liu, Ru Bai
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Patent number: 10772929Abstract: Method of use of peptides and their analogs in the treatment of acute pancreatitis are described. The disclosed peptides and analogs can significantly lower the elevated blood amylase and lipase levels caused by acute pancreatitis, reduce the degree of injury observed in pancreatic histopathology caused by pancreatitis, and significantly lower the mortality rate of acute pancreatitis.Type: GrantFiled: May 11, 2017Date of Patent: September 15, 2020Assignee: SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD.Inventors: Liping Liu, Ru Bai
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Patent number: 10301303Abstract: The invention provides various novel compositions of berberine in combination with pharmacologically active organic acids, and related methods of their use in treating various diseases or disorders. The invention further provides various novel compounds prepared from berberine and pharmacologically active organic acids and prepared from ursodeoxycholic acid and pharmacologically active organic bases, and pharmaceutical compositions thereof, and methods of their preparation and therapeutic use in treating and/or preventing various diseases or disorders.Type: GrantFiled: July 28, 2015Date of Patent: May 28, 2019Assignee: Shenzhen HighTide Biopharmaceutical, Ltd.Inventor: Liping Liu
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Patent number: 9738695Abstract: The invention provides peptides and analogs of INGAP and HIP peptides. The peptides and analogs can be used in methods for treating various diseases and conditions. Such diseases and conditions can include impaired pancreatic function, treating a metabolic disease, for example, diabetes, both type 1 and type 2 diabetes, islets induction, expansion and proliferation for transplantation, promoting neuroprotection or nerve regeneration, promoting liver regeneration or inhibiting inflammation.Type: GrantFiled: June 8, 2016Date of Patent: August 22, 2017Assignee: SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD.Inventors: Liping Liu, Ru Bai
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Patent number: 9388215Abstract: The invention provides peptides and analogs of INGAP and HIP peptides. The peptides and analogs can be used in methods for treating various diseases and conditions. Such diseases and conditions can include impaired pancreatic function, treating a metabolic disease, for example, diabetes, both type 1 and type 2 diabetes, islets induction, expansion and proliferation for transplantation, promoting neuroprotection or nerve regeneration, promoting liver regeneration or inhibiting inflammation.Type: GrantFiled: March 14, 2014Date of Patent: July 12, 2016Assignee: SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD.Inventors: Liping Liu, Ru Bai