Abstract: The present invention discloses a whole-body radiotherapy device with multiple radioactive sources, comprising rotary fixing frame, source body and collimator body whose rotating axis is parallel to the longitudinal axis of the treatment couch. Multiple radioactive sources and their beam channel are distributed in said source body, land the beam from said radioactive sources focus on the common focus point through said beam channel. The collimators are located in the collimator body, and they have the same distribution pattern as the radioactive sources. The source body and the collimator body are fixed on the rotary fixing frame and can be made to rotate around the rotating axis. In the radial sectional planes, radioactive sources and their beam channels are located within a fan shaped area whose included angle is less than 90°. With the guarantee of retaining enough treatment space for the whole body, the source-focus-distance is greatly reduced.