Abstract: A closed-loop artificial pancreas system based on a wearable monitoring method is provided.

Abstract: Use of phosphorus-based material in preparation of medicament for treating tumors. The phosphorus-based material is selected from a material which is convertible to produce phosphate ions in an acidic environment, and the phosphorus-based material can be converted by tumor cells phagocytosis to produce a large number of phosphate ions to change the intraceullar environment and extracellular environment, thereby inhibiting proliferation of tumor cells and inducing death of tumor cells. This process has no significant effect on normal cell activities. By applying the phosphorus-based material to the preparation of a medicament for treating tumor in a manner as mentioned above, the amplification and metastasis of tumor cells can be effectively inhibited, thereby the metastasis of the tumor cells and recurrence of the tumor can be prevented more effectively, improving the therapeutic effect of the tumor. The phosphorus-based material has little effect on normal cells and tissues in the course of treatment.

Abstract: The present application is suitable for the technical field of data processing, and provides a data error correction method and apparatus and an electronic device. The method includes: decoding a base sequence to be subjected to error correction into a first text, the base sequence to be subjected to error correction being composed of a plurality of bases; performing word segmentation on the first text to obtain a plurality of text units; performing error detection on the plurality of text units to obtain a text unit having an error; and performing error correction on the base sequence to be subjected to error correction according to the text unit having the error. By means of the above method, error correction for data can be achieved, and the storage cost of DNA can also be reduced.

Abstract: The present invention belongs to the field of nanomedicine, and provides a DC biomimetic membrane nanoparticle loaded with an NIR-II AIE dye, a preparation method therefor and use thereof. The DC biomimetic membrane nanoparticle loaded with the NIR-II AIE dye comprises a DC membrane and an NIR-II AIE dye loaded therein, wherein the NIR-II AIE dye has photothermal characteristics. The DC biomimetic membrane nanoparticle loaded with the NIR-II AIE dye provided by the present invention not only solves the problem that the NIR-II AIE dye is poor in water solubility and limited in fluorescence imaging, but also increases the enrichment efficiency of the NIR-II AIE dye coated by the DC membrane at a tumor site and successfully activates the activity of T cells in vivo.

Abstract: The present disclosure relates to an enhanced generative adversarial network and a target sample recognition method. The enhanced generative adversarial network in the present disclosure includes at least one enhanced generator and at least one enhanced discriminator, where the enhanced generator obtains generated data by processing initial data, and provides the generated data to the enhanced discriminator; the enhanced discriminator processes the generated data and feeds back a classification result to the enhanced generator; the enhanced discriminator includes: a convolution layer, a basic capsule layer, a convolution capsule layer, and a classification capsule layer, and the convolution layer, the basic capsule layer, the convolution capsule layer, and the classification capsule layer are sequentially connected to each other.

Abstract: A method for processing positron emission tomography data is provided, this method includes: obtaining a first coordinate and a second coordinate respectively corresponding to two ends of a response line to be processed; determining corresponding dimensional coordinates of the response line to be processed in a sinogram based on the first coordinate and the second coordinate; and generating the sinogram corresponding to the response line to be processed based on the dimensional coordinates. According to this method, the amount of calculation of system matrix is reduced, the accuracy of position information of the generated response line is improved, and the accuracy of generated sinogram is improved accordingly.

Abstract: The present invention provides a panoramic presentation method and apparatus. The present invention presents a panoramic image by using a combined structure of a single fisheye projector and a spherical screen in hardware, employs a geometrical relationship between a fisheye lens and the position of a viewer and isometric projection transformation, and enables 180° fisheye projection to present 720° environment information to the viewer in the center of the spherical screen, greatly simplifying the image conversion process and realizing zero distortion. According to a 720° panorama one-step generation method based on a single virtual camera in software, complex steps of collecting six images by a plurality of cameras, synthesizing a cube map and then converting the cube map into a panorama are not needed, the vertex position of a scene is directly adjusted in the process from a 3D space to a 2D image.

Abstract: A method for high-throughput TAG to TAA conversion on the genome are provided. The method comprises the following steps: co-transfecting a gRNA array pool or a transcription product thereof, a plasmid containing an mCherry-inactivated eGFP reporter molecule and an sgRNA plasmid for editing and activating eGFP in a stable cell of an inducible base editor; or by transfecting an 43-all-in-one expression vector or a transcription product thereof to cells with stable inducible base editor, high-flux TAG to TAA conversion in single cells is realized, and through multiple cyclic operations, almost all TAG to TAA conversion in the whole genome of cells of common model organisms can be realized.

Abstract: An Alzheimer's disease biomarker, and a screening method therefor and use thereof. The Alzheimer's disease biomarker is 11(Z), 14(Z)-eicosadienoic acid. The screening method for the Alzheimer's disease biomarker comprises: acquiring samples, testing the samples, and performing structural identification and data analysis on metabolites in the samples, wherein specifically, metabolites in faeces samples can be tested by liquid chromatography-mass spectrometry, to carry out structural identification on the metabolites; and selecting a metabolite showing a difference from the metabolite level of a control group as the Alzheimer's disease biomarker.

Abstract: A soft-bodied apparatus and a method for opening an eyelid are provided. The apparatus includes: a head support module, a real-time eyelid positioning module, a robot end-effector real-time positioning module, and an automatic eyelid opening operation module. The automatic eyelid opening operation module includes a robot body and a robot control system. The robot body is provided with a multi-axis rigid body mechanical arm and a soft-bodied end-effector. The robot control system takes the real-time poses of the upper and lower eyelids of the user as a motion target, and takes the real-time shape and the pose of the soft-bodied end-effector as feedback information to control motion of the robot body to automatically open the eyelid.

Abstract: A recombinant virus containing a degron, a preparation method therefor, and an application thereof. At least one viral protein of the recombinant virus containing the degron contains at least one degron capable of being recognized by a protein degradation system of a host cell, wherein the degron comprises any one of or a combination of at least two of an amino acid sequence, a polypeptide, or a structural motif. Further provided are a nucleic acid molecule, a recombinant vector, a preparation method for the recombinant virus containing the degron, a preparation system for the recombinant virus containing the degron, a vaccine, an oncolytic virus, and a drug. The recombinant virus containing the degron can be recognized and degraded by the protein degradation system in the host cell, the replication capability is weakened or even removed, and after a corresponding vaccine, oncolytic virus or drug is prepared, a good effect and practical application value are achieved.

Abstract: An ultrasonic image quality quantitative evaluation method includes segmenting a focus area aiming at a target ultrasonic image to extract a region of interest and perform a masking operation to acquire an image segmentation result mask; taking the image segmentation result mask as a reference image, and quantitatively comparing the reference image with a corresponding focus area according to a set evaluation standard to acquire a plurality of evaluation result indexes; and inputting the plurality of evaluation result indexes as an image feature into a classifier to acquire a quality quantification result of the focus area of the target ultrasonic image, where the classifier takes the plurality of evaluation result indexes corresponding to a sample image as an input feature, takes an image quality label of the labeled focus area as an output, and acquires the quality quantification result through training based on a set loss function.

Abstract: A shimming method and device, an electronic device, and a storage medium are disclosed. The shimming method includes: obtaining object static magnetic field distribution information corresponding to a target object, the object static magnetic field distribution information including the static magnetic field distribution information of the target object under the action of a main magnet of a magnetic resonance system; determining a target static magnetic field based on the object static magnetic field distribution information and a preset shim coil magnetic field distribution model; and adjusting at least one shim coil parameter in the shim coil magnetic field distribution model until a magnetic field uniformity of the target static magnetic field satisfies a preset condition, and accordingly obtaining at least one target shim coil parameter.

Abstract: A bacterial targeting vector and use thereof in tumor treatment, in particular, a bacterial targeting vector carrying a cytokine such as interleukin 6 and interleukin 10 or carrying a polynucleotide such as mRNA of the cytokine and use thereof in tumor treatment. An attenuated chassis bacterium capable of targeting solid tumors can be used as a delivery carrier of a tumor therapy molecule, and achieve expression and controllable release of a human/murine cytokine, thereby achieving anti-tumor effects.

Abstract: Disclosed in the present invention is A method for controlling heterogeneity of vascular endothelial cells by utilizing sympathetic nerves is provided, comprising expressing an artificial designer protein receptor exclusively activated by a designer drug in neuron cells, and then activating the artificial designer protein receptor by the designer drug, thereby activating or inhibiting neuronal activity to achieve control of the heterogeneity of the vascular endothelial cells. The method enables local modulation of the sympathetic nervous activity, thereby controlling the heterogeneity of the vascular endothelial cells, and can achieve bidirectional modulation. According to the present invention, the heterogeneity of bone vascular endothelial cells is controlled by manipulating the sympathetic nerves, such that the subtype of the bone vascular endothelial cells is controlled, thereby affecting the bone mineral density coupled therewith.

Abstract: The present application is applicable to the technical field of muscle oxygen saturation detection, and provides a muscle oxygen saturation detection method, and a muscle oxygen saturation recovery method and system. The muscle oxygen saturation detection method is applied to a muscle oxygen saturation detection device. The present application combines pulse electrical stimulation for relieving the muscle fatigue and improving the muscle activity function with muscle oxygen saturation detection, and automatically triggers the turning-on and turning-off of electrical stimulation with the muscle oxygen saturation detection data of a wearer to form a closed-loop muscle function detection and stimulation system with feedback.

Abstract: The invention relates to a method for constructing an obligate anaerobic Salmonella strain, the obligate anaerobic Salmonella strain constructed by using said method, and the use thereof in tumor therapy.

Abstract: A method for training a dialog generation model includes: acquiring a dialog data set, and encoding a post in the dialog data set by using an encoder in the dialog generation model to obtain an encoded representation of the post; fusing, by using a decoder in the dialog generation model, the encoded representation of the post and knowledge information corresponding to the post that is obtained from a knowledge base question answering model through transfer learning to obtain a predicted response corresponding to the post; determining a value of a loss function of the dialog generation model based on the predicted response and the annotated response that correspond to the post; and updating a model parameter of the dialog generation model based on the value of the loss function. A method, an apparatus, a device, and a computer storage medium for generating a dialog are also provided.

Abstract: A method and a device for a three-dimensional reconstruction of brain structure, and terminal equipment. The method includes steps of: obtaining a 2D image of a brain, inputting the 2D image of the brain into a 3D brain point-cloud reconstruction model that has been trained to be processed, and outputting a 3D point-cloud of the brain. The 3D brain point-cloud reconstruction model includes a ResNet encoder and a graphic convolutional neural network. The ResNet encoder is configured to extract a coding feature vector of the 2D image of the brain, and the graphic convolutional neural network is configured to construct the 3D point-cloud of the brain according to the coding feature vector.

Abstract: The present invention discloses a real-time ultrasonic stimulation electric signal recording chip and a preparation method thereof, where the preparation method includes the following steps: S1 manufacturing an interdigital electrode on a piezoelectric substrate to obtain a surface acoustic wave chip, and manufacturing a recording electrode and an electrode lead; S2, manufacturing an insulation protection layer on the chip obtained in the S1, and processing the insulation protection layer to form the recording electrode, so as to obtain a chip combining the interdigital electrode and the recording electrode; S3, preparing a PDMS cavity; and S4, bonding the PDMS cavity prepared in the S3 and the chip obtained in the S2. In the present invention, combining the interdigital electrode generating a surface acoustic wave ultrasound with a multi-channel recording electrode, such that real-time recording of a multi-channel electric signal under ultrasonic stimulation is achieved.