Patents Assigned to SHENZHEN PREGENE BIOPHARMA CO. LTD.
  • ANTI-BCMA SINGLE DOMAIN ANTIBODIES AND APPLICATION THEREOF
    Publication number: 20220251226
    Abstract: A group of anti-BCM single domain antibodies, as well as genes of the single domain antibodies in the group, a vector containing the single domain antibodies in the group, a chimeric antigen receptor, and a T cell modified by a chimeric antigen receptor, and detection and treatment application of the single domain antibodies in the group. The anti-BCMA single domain antibodies have high activity, high stability, high specificity, and high binding capability.
    Type: Application
    Filed: July 10, 2019
    Publication date: August 11, 2022
    Applicant: SHENZHEN PREGENE BIOPHARMA CO. LTD.
    Inventors: Jishuai ZHANG, Hongjian LI, ChaoLemeng BAO, Qinghua CAI, Yingying LI, Zongpei SONG, Yijin DING, Zhibo CAI
  • BCMA CHIMERIC ANTIGEN RECEPTOR BASED ON SINGLE DOMAIN ANTIBODY AND USE THEREOF
    Publication number: 20220218746
    Abstract: A chimeric antigen receptor (CAR) may be include: a BCMA binding domain, a transmembrane domain, a co-stimulatory domain, and an intracellular signaling domain, wherein the BCMA binding domain includes heavy chain complementarity determining regions HCDR1-3, and the amino acid sequences of the HCDR1-3 are successively as shown in SEQ ID NO: 1-3.
    Type: Application
    Filed: July 10, 2019
    Publication date: July 14, 2022
    Applicant: SHENZHEN PREGENE BIOPHARMA CO. LTD.
    Inventors: Jishuai ZHANG, Hongjian LI, Hongchang SU, Chaolemeng BAO, Zongpei SONG, Qinghua CAI, Yijin DING, Zhibo CAI