Abstract: An accommodating intraocular lens comprises a first lens component, a second lens component, and an adhesive between portions of the two lens components. The cured adhesive bonds the lens components to form a fluid chamber. The lens components are bonded to one another along a seam which extends circumferentially along at least a portion of the lens components. The lens components may comprise the same polymer material. The cured adhesive also comprises the polymer or a prepolymer of the polymer to provide increased strength. The polymer is hydratable such that the lens components and the cured adhesive therebetween can swell together to inhibit stresses between the lens components and the cured adhesive.
Type:
Grant
Filed:
February 14, 2014
Date of Patent:
November 8, 2016
Assignee:
Shifamed Holdings, LLC
Inventors:
Claudio Argento, Bob Vaughan, Amr Salahieh, Tom Saul
Abstract: Disrupting tissue and devices and systems for disrupting tissue. The disclosure describes ways to deliver moieties to a target tissue, where the target tissue in general is not at the point of introduction, in such a way that minimal damage is produced in the tissue at the point of introduction. In some embodiments this is accomplished by jetting fluid at high velocity into the target tissue. The disclosure further describes novel agents deliverable in such systems for use in remodeling tissues. Some of these agents comprise a liquid while others do not. Additionally, although not specifically described in detail much of the disclosure may additionally be used in the delivery of therapeutic drugs.
Type:
Grant
Filed:
March 24, 2011
Date of Patent:
September 23, 2014
Assignee:
Shifamed Holdings, LLC
Inventors:
Amr Salahieh, Alan Schaer, Jeff Krolik, John Spiridigliozzi, Suresh Pai, Tom Saul
Abstract: An accommodating intraocular lens comprises a first lens component, a second lens component, and an adhesive between portions of the two lens components. The cured adhesive bonds the lens components to form a fluid chamber. The lens components are bonded to one another along a seam which extends circumferentially along at least a portion of the lens components. The lens components may comprise the same polymer material. The cured adhesive also comprises the polymer or a prepolymer of the polymer to provide increased strength. The polymer is hydratable such that the lens components and the cured adhesive therebetween can swell together to inhibit stresses between the lens components and the cured adhesive.
Type:
Application
Filed:
February 14, 2014
Publication date:
August 14, 2014
Applicant:
Shifamed Holdings, LLC
Inventors:
Claudio ARGENTO, Bob VAUGHAN, Amr SALAHIEH, Tom SAUL
Abstract: A tissue electrode assembly includes a membrane configured to form an expandable, conformable body that is deployable in a patient. The assembly further includes a flexible circuit positioned on a surface of the membrane and comprising at least one base substrate layer, at least one insulating layer and at least one planar conducting layer. An electrically-conductive electrode covers at least a portion of the flexible circuit and a portion of the surface of the membrane not covered by the flexible circuit, wherein the electrically-conductive electrode is foldable upon itself with the membrane to a delivery conformation having a diameter suitable for minimally-invasive delivery of the assembly to the patient.
Type:
Grant
Filed:
May 12, 2011
Date of Patent:
August 12, 2014
Assignee:
Shifamed Holdings, LLC
Inventors:
Amr Salahieh, Jonah Lepak, Emma Leung, Brian D. Brandt, John P. Claude, Tom Saul
Abstract: A tissue electrode assembly includes a membrane configured to form an expandable, conformable body that is deployable in a patient. The assembly further includes a flexible circuit positioned on a surface of the membrane and comprising at least one base substrate layer, at least one insulating layer and at least one planar conducting layer. An electrically-conductive electrode covers at least a portion of the flexible circuit and a portion of the surface of the membrane not covered by the flexible circuit, wherein the electrically-conductive electrode is foldable upon itself with the membrane to a delivery conformation having a diameter suitable for minimally-invasive delivery of the assembly to the patient.
Type:
Grant
Filed:
November 11, 2009
Date of Patent:
October 23, 2012
Assignee:
Shifamed Holdings, LLC
Inventors:
Amr Salahieh, Jonah Lepak, Emma Leung, Brian Brandt, John P. Claude