Patents Assigned to SHIJIAZHUANG PHARMACEUTICAL GROUP OUYL PHAMA CO., LTD
  • Method for the enantiomoeric separation of optical active amlodipine
    Publication number: 20070093661
    Abstract: The present invention relates to the preparation of the (S)-(?)-amlodipine and (R)-(+)-amlodipine by means of enantiomoeric separation of racemic amlodipine mixture, in which, L- or D-tartaric acid is used as resolution agent, and organic solvent containing 2-butone is used as solvent. The 2-butone used in the present invention has the advantage of low boiling point, low toxicity, litter pollution, and the method is suitable for large-scaled production.
    Type: Application
    Filed: December 3, 2004
    Publication date: April 26, 2007
    Applicant: SHIJIAZHUANG PHARMACEUTICAL GROUP OUYL PHAMA CO., LTD
    Inventors: Nanping Zhong, Xianfeng Zhao, Hui Ma, Yujle Chen