Patents Assigned to Shimadzu Corporation
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Publication number: 20110315458Abstract: A sensor mechanism body having a main Roberval mechanism; a sub-Roberval mechanism provided with a second fixed column connected with an electronic balance base, a second movable column supporting the load of an internal weight placed on an engaging section, and two second beams, parallel to each other, and connecting the second movable column to the second fixed column. A first lever rockably supported by a first fulcrum, connected to one end of a first movable column of the main Roberval mechanism, and the other end connected to a second lever. The second lever rockably supported by a second fulcrum, connected to one end of a second movable column of the sub-Roberval mechanism, and the other end connected to an electromagnetic force generating device and the other end of the first lever. The second fixed column is connected to the second lever through a thin-walled connecting.Type: ApplicationFiled: February 10, 2009Publication date: December 29, 2011Applicant: SHIMADZU CORPORATIONInventors: Tetsuro Kusumoto, Toshihiro Koide
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Publication number: 20110316551Abstract: A technique for reducing an electromagnetic noise entering an electrode or a drift of a signal due to a fluctuation in the ambient temperature is provided to improve the S/N ratio of a signal originating from a component of interest. A dummy electrode 11 having the same structure as an ion-collecting electrode 10 is provided within a lower gas passage 14 at a position where dilution gas with no sample gas mixed therein flows. A differential amplifier 14 is provided to perform differential detection between output A of a current amplifier 21 connected to the ion-collecting electrode 10 and output B of a current amplifier 22 connected to the dummy electrode 11. The differential signal is free from a common mode noise or drift and hence accurately reflects the amount of the component of interest.Type: ApplicationFiled: June 23, 2011Publication date: December 29, 2011Applicants: OSAKA UNIVERSITY, SHIMADZU CORPORATIONInventors: Kei SHINADA, Shigeyoshi HORIIKE, Takahiro NISHIMOTO, Katsuhisa KITANO
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Publication number: 20110315874Abstract: When specimen (4) is placed on specimen stage (2), controller (32)—via the stage driver (33) and drive mechanism (6)—moves the specimen stage (2) by a predetermined step pitch according to the magnification factor in the X-direction and the Y-direction, and the image pickup unit (7) acquires a microscopic observation image of the specimen (4) after each move. The microscopic observation image that is acquired and the position data of the specimen stage (2) when the image is acquired are stored in memory (321). When a plurality of microscopic observation images of the areas that are adjacent on the specimen (2) are obtained, the image integration processor (322) uses the position data to join the microscopic observation images. When a plurality of microscopic observation images that encompasses the entirety of the specimen (2) is all joined together to form a specimen observation image, the specimen observation image is displayed on a display unit 37.Type: ApplicationFiled: March 5, 2009Publication date: December 29, 2011Applicant: SHIMADZU CORPORATIONInventors: Masahiro Ikegami, Kiyoshi Ogawa, Takahiro Harada
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Publication number: 20110307979Abstract: To provide a scanning probe microscope wherein the scanning means is not damaged by fluids, the scanning probe microscope 30 comprises a cantilever support part 2 for supporting a cantilever 1; displacement measurement parts 3, 4, 5 and 6 for measuring the displacement of the cantilever 1; a specimen container 11 comprising sidewalls 19 and bottom surface 18 and containing a fluid 10 and a specimen S; a carrying stage 40 on which the specimen container 11 is placed; and a scanning means 7 for moving and scanning the carrying stage 40. While the cantilever 1 is immersed in the fluid 10 that is contained in the specimen container 11, the carrying stage 40 is moved, and the displacement of the cantilever 1 is measured. The scanning probe microscope 30 further comprises a ring-shaped protective mat 50 that is capable of absorbing the fluid 10. A mounting mechanism 43 is formed on the outer peripheral surface of the carrying stage 40 for removably attaching the protective mat 50 by its inner peripheral area.Type: ApplicationFiled: March 28, 2011Publication date: December 15, 2011Applicant: SHIMADZU CORPORATIONInventors: Kanji KOBAYASHI, Hideo NAKAJIMA
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Publication number: 20110303842Abstract: When performing an automatic MS2 analysis on a specimen containing components that include elements whose abundance ratio of stable isotopes is close, to prevent the same component that includes isotopes of differing masses to be successively selected as a precursor ion and allow the MS2 analysis of various components whose retention time to elution is close. As precursor selection conditions, the user is allowed to set in advance the time period for automatic exclusion and a m/z range (?p, q) with respect to any m/z. When the analysis is performed, a precursor selection unit selects a precursor according to a predetermined selection condition for the MS spectrum that was obtained and repeats the MS2 analysis on the precursor ion (m/z=M) for the number of times that is set. Thereafter, for a specified automatic exclusion period, ions falling in a m/z range of M?p to M+q are excluded from selection as a precursor.Type: ApplicationFiled: April 19, 2011Publication date: December 15, 2011Applicant: SHIMADZU CORPORATIONInventor: Shigenobu NAKANO
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Patent number: 8075768Abstract: A liquid chromatograph device was provided wherein operations inside a thermostatic chamber can be safely performed even while a heat block is being heated. The liquid chromatograph device comprises: a thermostatic chamber; outer doors and that are disposed at the front surface of the thermostatic chamber; a heat block; heater for heating said heat block; temperature sensor for the heat block; flowing means for flowing air between the inside and outside of the thermostatic chamber; a control means for controlling the supply of power to the heater based on the result of the temperature sensor; and an inner door between the outer door and the heat block, the inner door comprising a hollow inner door main body, a heat-insulating material that is housed within the inner door so as to form an air chamber between the heat-insulating material and the surface of the outer door of the inner door main body and inlet/outlet slits and that are formed in the inner door main body.Type: GrantFiled: May 13, 2011Date of Patent: December 13, 2011Assignee: Shimadzu CorporationInventor: Takao Okado
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Patent number: 8076129Abstract: The reactor plate preferably includes a sealed reactor, a reactor flow channel connected to the reactor, a sample container constituted from a sealed container provided separately from the reactor, a sample container flow channel to be connected to the sample container, a syringe for sending a liquid, a switching valve for connecting the syringe to the reactor flow channel or the sample container flow channel, and a projecting flow channel connected to the end of the sample container flow channel located on the sample container side. The sample container has a penetrable portion through which the projecting flow channel can penetrate and which is provided to be opposed to the projecting flow channel and is located such that the projecting flow channel penetrating the penetrable portion is brought into contact with a liquid contained in the sample container. The sample container can be connected to the sample container flow channel.Type: GrantFiled: July 24, 2008Date of Patent: December 13, 2011Assignee: Shimadzu CorporationInventors: Nobuhiro Hanafusa, Koretsugu Ogata
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Publication number: 20110293401Abstract: A turbomolecular pump includes: a rotor (30) formed with rotating blades (32) in a plurality of stages, and rotating at high speed; a plurality of fixed blades (33) arranged along axial direction of the pump so as to alternate with respect to the rotating blades (32); a pump housing (34) containing the rotating blades (32) and the fixed blades (33), and formed with an inlet opening (21a); a circular disk (150), provided close to the inlet opening of the rotor (30), and arranged so as to oppose a surface of the rotor (30) radially inward than a root portion of the rotating blades; and a cylindrical mesh structure (153a, 153b), disposed between the inlet opening (21a) and the rotor (30), and made by interlacing fine wires. Particles that strike the rotor and bounce off are captured internally in the mesh structure (153a, 153b).Type: ApplicationFiled: February 5, 2010Publication date: December 1, 2011Applicants: TOKYO ELECTRON LIMITED, SHIMADZU CORPORATIONInventors: Yukiteru Sekita, Kazuma Kubota, Tsuyoshi Moriya, Eiichi Sugawara
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Publication number: 20110290042Abstract: The present invention provides a liquid sample injection device and liquid sample injection method using a total volume injection method, which can prevent clogging of the channel or the needle, or carry-over of analysis components. The present invention is characterized by: moving the tip of a needle 9, before collecting a liquid sample, to an area where a predetermined fluid (for example, air, water, or the like) which reacts with neither the liquid sample nor the mobile phase is present; sucking the given fluid from the tip; and inserting the tip into a vial 15 to suck a predetermined amount of the liquid sample in the vial 15. As a result, a layer of the predetermined fluid is formed between the mobile phase remaining in the needle 9 and the newly sucked liquid sample. Thus, the mobile phase and the liquid sample are prevented from being in contact with each other in the needle 9.Type: ApplicationFiled: May 18, 2011Publication date: December 1, 2011Applicant: SHIMADZU CORPORATIONInventor: Yoshiaki MAEDA
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Publication number: 20110290233Abstract: A column oven that may enable a heat block to provide the best temperature distribution, and increase temperature evenness of a column is provided. In a column oven 400 that heats or cools a heat block 10 contacting a column 40 and adjusts temperature of the column 40 through heat transmission from the heat block 10, a plurality of temperature adjustment bodies 21 and 22 is separately disposed along the longitudinal direction of the heat block 10, and heats or cools the heat block 10, a plurality of temperature sensors 31 and 32 measuring the temperatures of the heat block 10 adjacent to the temperature adjustment bodies 21 and 22 is also disposed, and the corresponding temperature adjustment bodies 21 and 22 are controlled independently according to the temperatures measured by the temperature sensors 31 and 32.Type: ApplicationFiled: February 21, 2011Publication date: December 1, 2011Applicant: SHIMADZU CORPORATIONInventors: KEISUKE ISO, Takao Okado
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Patent number: 8067747Abstract: A system for guiding an ion beam along an axis (Z), comprises at least one section having upper flat plate strip electrodes (Iu, 2u, 3u, 4u and 5u) and lower flat plate strip electrodes (Id, 2d, 3d, 4d and 5d) for producing at least one electric field of substantially symmetric in a parallel direction and substantially antisymmetric in a perpendicular direction with respect to a plane including a beam axis and a fringe-field boundary that is located at the end of the at least one section.Type: GrantFiled: May 22, 2006Date of Patent: November 29, 2011Assignee: Shimadzu CorporationInventor: Hermann Wollnik
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Patent number: 8067176Abstract: A chemical reaction is conducted in a fluid of a droplet inside a reaction receptacle or on a surface of a reaction substrate. Fluctuations of a magnetic field are applied to the droplet including an aqueous solution having magnetic body particles with a hydrophilic surface, and a physical force is transmitted to the surrounding aqueous solution through the magnetic body particles. The droplet is thus moved by the physical force to conduct an operation necessary for a chemical reaction.Type: GrantFiled: January 25, 2008Date of Patent: November 29, 2011Assignee: Shimadzu CorporationInventor: Tetsuo Ohashi
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Patent number: 8067729Abstract: In a mass analysis data analyzing apparatus, centroid data is used as mass spectrum data to be analyzed. First, peaks on the centroid data are specified in order of intensity as a standard peak for identifying an isotopic cluster. The isotopic cluster is detected by comparing an emerging pattern of peaks near the standard peak and an emerging pattern of peaks of an expected isotopic cluster in the case where each valence is assumed. The valence of the determined isotopic cluster is set as the valence of the peaks belonging to the isotopic cluster, and the peak at the forefront of cluster is selected as a monoisotopic peak. With such a mass analysis data analyzing apparatus, it is possible to determine the valence of each peak and identify the monoisotopic peak in a mass spectrum.Type: GrantFiled: April 26, 2010Date of Patent: November 29, 2011Assignee: Shimadzu CorporationInventors: Kazuo Yamauchi, Yoshitake Yamamoto, Yoshikatsu Umemura
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Publication number: 20110284740Abstract: A mass analysis of a standard sample having a known mass-to-charge ratio is carried out by performing a mass scan at a first-stage quadrupole (13) over a predetermined mass range, under the condition that a collision induced dissociation (CID) gas is introduced into a collision cell (14) and a voltage applied to a third-stage quadrupole (17) is set so that no substantial mass separation occurs in this quadrupole. Various kinds of product ions originating from a precursor ion selected by the first-stage quadrupole (13) arrive at and are detected by a detector (18) without being mass separated. Accordingly, based on the detection data, a data processor (25) can obtain a relationship between the voltage applied to the first-stage quadrupole (13) and the mass-to-charge ratio of the selected ions, with a time delay in the collision cell (14) reflected in that relationship. This relationship is stored in a calibration data memory (26), to be utilized in a neutral loss scan measurement or the like.Type: ApplicationFiled: February 5, 2009Publication date: November 24, 2011Applicant: SHIMADZU CORPORATIONInventor: Daisuke Okumura
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Publication number: 20110288397Abstract: Provided is a medical image diagnosis apparatus which requires a small area for installation, has a short length in an axial direction of the apparatus, can reduce a problem of the strength of a top plate, and can simultaneously carry out dynamic PET-imaging of the entire body. A top plate (61) on which an examinee lies is moved through a tunnel of a CT gantry (2) and a PET gantry (3) to execute CT imaging and PET imaging. A PET unit consisting of a plurality (e.g. seven) of PET units (32) has a length of 2 m in the axis direction, the visual field thereof covers the whole body and the whole body can be simultaneously subjected to dynamic PET-imaging. For the maintenance of the PET gantry (3), the diagnosis apparatus is separated at an arbitrary PET unit (32) to be maintained, the apparatus slides on a rail (31) in the axis direction and is separated for maintenance operation. Accordingly, a large space for maintenance is not required and the area for installation is small.Type: ApplicationFiled: February 3, 2009Publication date: November 24, 2011Applicant: SHIMADZU CORPORATIONInventors: Yoshihiro Inoue, Masaharu Amano, Kazumi Tanaka, Tetsuro Mizuta, Atsushi Ohtani
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Patent number: 8063320Abstract: An electronic balance is provided, which adequately exhibits quick response and displaying stability when being used to measure a number of objects. The electronic balance includes a number-of-objects calculating section, for counting a number (Nwa) of objects from the moving average (Wa) and the unit weight (Wu) when the moving average process is being executed and counting a number (Nw) of objects from the load value (W) and the unit weight (Wu) when the moving average process stops; and a display section, for displaying the calculated numbers (Nw, Nwa) of the to-be-measured objects.Type: GrantFiled: September 20, 2007Date of Patent: November 22, 2011Assignee: Shimadzu CorporationInventors: Hiroshi Hamamoto, Masahiro Katoh
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Patent number: 8058610Abstract: A sample plate 3 with a sample 4 placed thereon is initially set on a stage 2, and a visual image of the sample is taken with a CCD camera 14. This image is stored in an image data memory 23. Then, an operator removes the sample plate 3, sprays a matrix for a MALDI process onto the sample 4 and replaces the plate onto the stage 2. After that, when a predetermined operation is made, a clear image of the sample taken before the application of the matrix is shown on a display unit 24. On this image, the operator specifies a point or area for the analysis. The sample 4 may have been displaced due to the removal and replacement of the plate 3. Accordingly, an image analyzer 44 calculates the direction and magnitude of the displacement, for example, by recognizing the position of the markings provided on the sample plate 3. A displacement corrector 42 computes coordinate values in which the displacement is corrected.Type: GrantFiled: December 5, 2006Date of Patent: November 15, 2011Assignee: Shimadzu CorporationInventors: Takahiro Harada, Sadao Takeuchi, Kiyoshi Ogawa, Mitsutoshi Setou
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Patent number: 8059880Abstract: In a state in which a subject is absent, blank data is collected by a self-radioactivity element typified by Lu-176 (S1). In a state in which the subject is present, transmission data is collected by the self-radioactivity element (S2). Emission data is collected by ? rays emitted from the subject injected with a radiopharmaceutical (S3). Absorption-corrected data is calculated based on the blank data and the transmission data (S4 to S7), and the emission data is absorption-corrected using the absorption-corrected data (S8). Although such background data obtained by the self-radioactivity is originally abandoned, the background data is rather used for the absorption-corrected data. Stable absorption correction can be thereby conducted.Type: GrantFiled: December 26, 2008Date of Patent: November 15, 2011Assignee: Shimadzu CorporationInventors: Tetsuro Mizuta, Keishi Kitamura
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Publication number: 20110275914Abstract: Provided is a light measurement device capable of obtaining reproducible measurement data without the necessity for bringing a subject into the state of performance of a task such as finger movement many times, the measurement data having no variation and less affected by Mayer Wave and the like caused by respiration, blood pressure, and the like other than the performance of the task.Type: ApplicationFiled: January 12, 2010Publication date: November 10, 2011Applicant: SHIMADZU CORPORATIONInventor: Satoru Kohno
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Publication number: 20110266438Abstract: A mass spectrometer capable of obtaining a clear microscopic observation image with high spatial resolution in real time, even during a mass analysis, without affecting the analysis is provided. An aperture 1a is formed in a stage 1 on which a sample plate 2 to be placed. The sample plate 2 is transparent or translucent. A microscopic observation unit, including an observation optical system 20 and a CCD camera 21, is provided below the stage 1 to observe the reverse side of the sample 3 through the aperture 1a of the stage 1 as well as the transparent sample plate 2. The observed image is displayed on the screen of a display unit 27. If the sample 3 is a slice of biological tissue, the sample image taken from the reverse side will be substantially the same as an image taken from the obverse side.Type: ApplicationFiled: April 26, 2011Publication date: November 3, 2011Applicants: National University Corporation Hamamatsu University School of Medicine, SHIMADZU CORPORATIONInventors: Takahiro HARADA, Kiyoshi OGAWA, Mitsutoshi SETOU