Abstract: Provided is a diagnostic drug for evaluating permeability of intestinal mucosa, including chitin and/or chitosan as a main component. The chitin and/or chitosan to be used preferably has a weight average molecular weight prepared to a range of from 1,000 to 11,600.

Abstract: A method for analyzing leucine and isoleucine for newborn mass-screening or similar tests by multiple reaction monitoring (MRM) measurements using a tandem mass spectrometer is provided. The method includes: a measurement step for acquiring intensity information of ions originating from leucine and isoleucine by performing, on a specimen, a first MRM measurement for at least one MRM transition selected from a group of m/z 132>69, m/z 132>57, m/z 132>56, m/z 132>43, m/z 132>41, m/z 132>39, m/z 132>30 and m/z 132>27 as well as a second MRM measurement for an MRM transition of m/z 132>86; and a processing step for discriminating whether the specimen contains leucine or isoleucine, or for determining a relative abundance of leucine and isoleucine in the specimen, based on a qualifier ion ratio which is a ratio between a signal intensity obtained by the first MRM measurement and a signal intensity obtained by the second MRM measurement.

Abstract: Provided is a method by which the disaccharides derived from glycosaminoglycans can be analyzed in a stable and highly reproducible manner. A method for analyzing a glycosaminoglycan according to the present invention includes: a first process for producing a plurality of kinds of disaccharides derived from a glycosaminoglycan in a biological sample by adding a plurality of kinds of glycosaminoglycan-specific enzymes to the biological sample; and a second process for separating and analyzing the plurality of kinds of disaccharides by a liquid chromatography-mass spectrometry method, where a column used for liquid chromatography in the liquid chromatography-mass spectrometry method is a column packed with a stationary-phase support to which an amide group as a functional group is bound, or a column packed with a stationary-phase support to which an adamantyl group as a functional group is bound.

Abstract: First and second MRM transitions for a target substance, a first reference value concerning a measured intensity of the first MRM transition, and a second reference value concerning the measured-intensity ratio between the first and second MRM transitions are set. MRM measurements of an analyte sample using the first and second MRM transitions are performed to obtain a first intensity of the first MRM transition and a second intensity of the second MRM transition (Steps 11 and 12). The value of the first intensity is compared with the first reference value to determine whether the target substance is possibly contained (first determination; Step 14). For a target substance considered to be possibly contained in the analyte sample, the ratio between the first and second intensities is compared with the second reference value to determine whether the target substance is contained (second determination; Step 18).

Abstract: The present invention provides a hollow fiber membrane oxygenator comprising a housing comprising a blood flow path; a blood inlet port and a blood outlet port disposed in the housing so as to allow blood to flow through the blood flow path; a gas exchange part comprising a bundle of a plurality of hollow fiber membranes disposed in the blood flow path, a gas inflow port and a gas outflow port provided in the housing so as to allow an oxygen-containing gas to flow through lumens of the hollow fiber membranes, and a gas temperature control part for adjusting the temperature of a gas flowing through the lumens of the hollow fiber membranes.

Abstract: An ultrasonic transverse wave is transmitted or ultrasonic longitudinal wave and transverse wave are transmitted in a perpendicular direction to a bonding interface between materials by transmission such as a probe. A reflection signal of the transmitted transverse wave reflected by the bonding interface and/or a transmission signal of the transmitted transverse wave transmitted through the bonding interface and the longitudinal wave, a reflection signal of the transmitted longitudinal wave reflected by the bonding interface and/or a transmission signal of the transmitted longitudinal wave transmitted through the bonding interface are received by reception such as the probe.

Abstract: One mode of a method for analyzing acylcarnitine according to the present invention is a method for analyzing C5 acylcarnitine using a tandem mass spectrometer, the method including: a measurement step of performing MRM measurement on a specimen according to at least one of MRM transitions of m/z 24>187, m/z 246>57, m/z 246>41, and m/z 246>29; and a processing step of distinguishing between isovalerylcarnitine and pivaloylcarnitine which is an isomer of isovalervicarnitine in the specimen or determining whether or not C5 acylcarnitine in the specimen includes pivaloylcarnitine, using a measurement result obtained in the measurement step. This makes it possible to satisfactorily distinguish between isovalerylcarnitine and pivaloylcarnitine, which have been conventionally difficult to distinguish.

Abstract: Provided is a method by which the disaccharides derived from glycosaminoglycans can be analyzed in a stable and highly reproduceable manner. A method for analyzing a glycosaminoglycan according to the present invention includes: a first process for producing a plurality of kinds of disaccharides derived from a glycosaminoglycan in a biological sample by adding a plurality of kinds of glycosaminoglycan-specific enzymes to the biological sample: and a second process for separating and analyzing the plurality of kinds of disaccharides by a liquid chromatography-mass spectrometry method, where a column used for liquid chromatography in the liquid chromatography-mass spectrometry method is a column packed with a stationary-phase support to which an amide group as a functional group is bound, or a column packed with a stationary-phase support to which an adamantyl group as a functional group is bound.

Abstract: The present invention provides a hollow fiber membrane oxygenator comprising a housing comprising a blood flow path; a blood inlet port and a blood outlet port disposed in the housing so as to allow blood to flow through the blood flow path; a gas exchange part comprising a bundle of a plurality of hollow fiber membranes disposed in the blood flow path, a gas inflow port and a gas outflow port provided in the housing so as to allow an oxygen-containing gas to flow through lumens of the hollow fiber membranes, and a gas temperature control part for adjusting the temperature of a gas flowing through the lumens of the hollow fiber membranes.

Abstract: The present invention provides fermented milk having a high angiotensin converting enzyme inhibition activity, a high hypotensive activity and/or a high stroke-preventing activity. The present invention also provides a method for producing fermented milk having a high angiotensin converting enzyme inhibition activity, a high hypotensive activity and/or a high stroke-preventing activity and a method for producing Tyr-Pro, each of which is characterized by comprising fermenting milk with a mushroom.

Abstract: A measurement method for measuring an effective refractive index difference between two propagation modes of a multimode fiber is provided. The method includes: measuring a first Brillouin frequency shift ?1 by specifying a frequency having a lowest-frequency peak out of peaks in a first frequency spectrum of scattered light in a first propagation mode; measuring a second Brillouin frequency shift ?2 by specifying a frequency having a lowest-frequency peak out of peaks in a second frequency spectrum of scattered light in a second propagation mode; and calculating an effective refractive index difference ?neff in accordance with ?neff=(?1??2)/(2kVL) with use of the first Brillouin frequency shift ?1, the second Brillouin frequency shift ?2, a predetermined wave number k of light in a vacuum, and a predetermined constant VL.

Abstract: A headlight (1) for a healthcare worker includes: a base part (10), which has a U-shape, is configured to come into abutment, at a center part of the base part (10), with a back side of a head and neck part of a wearer, and includes a right end part (11) and a left end part (11), each of which is configured to be hung on an upper part of an ear so that the base part (10) is retained on a head; a light source device (20), which extends from both or any one of a vicinity of the end parts (11), includes LEDs as light sources, and is configured to illuminate a region in front of the head; and a controller (30) configured to control an illumination state of the light source device (20). The controller (30) is configured to light the light source device (20) when the base part (10) reaches a predetermined depression angle with a standing state of the wearer serving as a reference.

Abstract: The present invention provides fermented milk having a high angiotensin converting enzyme inhibition activity, a high hypotensive activity and/or a high stroke-preventing activity. The present invention also provides a method for producing fermented milk having a high angiotensin converting enzyme inhibition activity, a high hypotensive activity and/or a high stroke-preventing activity and a method for producing Tyr-Pro, each of which is characterized by comprising fermenting milk with a mushroom.

Abstract: This internal pressure loading system includes an internal pressure loading device and an information processing device. The internal pressure loading device is set at an inner face of a pipe, and includes a load meter which detects the load applied to the inner face of the pipe and a displacement meter which detects the deformation amount of the pipe. When the internal pressure loading device is expanded so as to increase the load to be detected by the load meter, the width of the pipe at which the displacement meter is located is reduced. On the basis of the load detected by the load meter and the deformation amount detected by the displacement meter, the information processing device evaluates the remaining strength of the pipe.

Abstract: A measurement method for measuring an effective refractive index difference between two propagation modes of a multimode fiber is provided. The method includes: measuring a first Brillouin frequency shift v1 by specifying a frequency having a lowest-frequency peak out of peaks in a first frequency spectrum of scattered light in a first propagation mode; measuring a second Brillouin frequency shift v2 by specifying a frequency having a lowest-frequency peak out of peaks in a second frequency spectrum of scattered light in a second propagation mode; and calculating an effective refractive index difference ?neff in accordance with ?neff=(v1?v2)/(2kVL) with use of the first Brillouin frequency shift v1, the second Brillouin frequency shift v2, a predetermined wave number k of light in a vacuum, and a predetermined constant VL.

Abstract: A scintillator includes a support substrate, an emission layer formed on the substrate, made of ZnO with impurities added to have an electron concentration of 2×1019 cm?3 or more and 2×1020 cm?3 or less, and for generating scintillation light in response to incidence of radiation, a protective layer formed on the emission layer and made of a material having a hand gap wider than that of ZnO, and a metal layer formed on the protective layer. The support substrate is made of a material transmitting the scintillation light generated in the emission layer. Further, the metal layer functions as a reflection layer for reflecting the scintillation light from the emission layer.

Abstract: A scintillator includes a support substrate, an emission layer formed on the substrate, made of ZnO with impurities added to have an electron concentration of 2×1019 cm?3 or more and 2×1020 cm?3 or less, and for generating scintillation light in response to incidence of radiation, a protective layer formed on the emission layer and made of a material having a band gap wider than that of ZnO, and a metal layer formed on the protective layer. The support substrate is made of a material transmitting the scintillation light generated in the emission layer. Further, the metal layer functions as a reflection layer for reflecting the scintillation light from the emission layer.

Abstract: This internal pressure loading system includes an internal pressure loading device and an information processing device. The internal pressure loading device is set at an inner face of a pipe, and includes a load meter which detects the load applied to the inner face of the pipe and a displacement meter which detects the deformation amount of the pipe. When the internal pressure loading device is expanded so as to increase the load to be detected by the load meter, the width of the pipe at which the displacement meter is located is reduced. On the basis of the load detected by the load meter and the deformation amount detected by the displacement meter, the information processing device evaluates the remaining strength of the pipe.

Abstract: A bidirectional DC-DC converter includes a series circuit of a first winding of a first reactor, a second reactor, and a first switch connected to both ends of a first DC power source, a series circuit of a second switch and a second DC power source connected to both ends of the first switch, a series circuit of a second winding of the first reactor, a third reactor, a first selector switch, and a first diode connected to both ends of a series circuit of the second reactor and the first switch, a series circuit of a second selector switch, a second diode, and the second DC power source connected to both ends of a series circuit of the first selector switch and first diode, and a controller turning on/off the switches and the selector switches.

Abstract: A plurality of cores 51 is disposed around the center axis of a first cladding 52 in a state in which an inter-core distance ? of cores adjacent to each other is equal, a refractive index n1 of the core 51 is provided higher than a refractive index n2 of the first cladding 52, and the refractive index n2 of the first cladding 52 is provided higher than a refractive index n3 of a second cladding 53. Moreover, 5.8??/MFD(2?c/(?c+?op))?8 is satisfied, where the inter-core distance is defined as ?, a mode field diameter of the core is defined as MFD, a cutoff wavelength is defined as ?c, and a wavelength of communication light incident on the core 51 is defined as ?op.