Abstract: This invention relates to a new compound, epoxyvibsanin B, which can be used to treat an IL-12 overproduction-related disorder such as an inflammatory disease.
Abstract: The invention relates to a quinone derivative of the following formula:
which is capable of converting into two alkylating agents upon bioreduction. Substituents A, B, C, and D are as described herein.
Abstract: The invention relates to a compound of formula (I) which can inhibit the production of IL-12. Also disclosed is a method of inhibiting IL-12 production by administering to a patient in need thereof an effective amount of a compound of formula (I).
Type:
Grant
Filed:
June 15, 2000
Date of Patent:
May 7, 2002
Assignee:
Shionogi Bioresearch Corp.
Inventors:
Mitsunori Ono, Yumiko Wada, Beatrice Brunkhorst, Tadeusz Warchol, Wojciech Wrona, Dan Zhou, Nha Huu Vo, Stephen Gillies
Abstract: A cyanoguanidine compound of the following formula:
is disclosed. A cyanoguanidine compound of the present invention possess a high specificity for tumor cells. Also disclosed are methods for preparing a cyanoguanidine compound.
Abstract: The present invention relates to bis(haloethyl)aminobenzene derivatives featured by having carboxyl-containing moiety and one other moiety at the ortho position with respect to the bis(haloethyl)amino substituent of the benzene ring. The moiety at the ortho position can be alkyl, cycloalkyl, heterocycloalkyl, aryl heteroaryl, alkyl(cycloalkyl), alkyl(heterocycloalkyl), alkyl(heteroaryl), alkyl(aryl), --(--O-alkyl).sub.2-5 or --Y.sup.1 --Y.sup.2 in which Y.sup.1 is O, S, or N(R.sup.5) wherein R.sup.5 is hydrogen or alkyl, and Y.sup.2 is alkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl, heteroacryl, alkyl(cycloalkyl), alkyl(hetero-cycloalkyl), alkyl(aryl), or alkyl(heteroaryl).
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