Patents Assigned to Shire LLC
  • Patent number: 7375082
    Abstract: The present invention decreases the potential for abuse of opioids, particularly hydrocodone, by covalent modification. The invention provides methods of delivering hydrocodone as conjugates that release the hydrocodone following oral administration while being resistant to abuse by circuitous routes such as intravenous (“shooting”) injection and intranasal administration (“snorting”). Further, hydrocodone compositions of the invention are resistant to oral abuse as well, since release of the hydrocodone at suprapharmacological doses reaches saturation.
    Type: Grant
    Filed: September 30, 2004
    Date of Patent: May 20, 2008
    Assignee: Shire LLC
    Inventors: Travis Mickle, Suma Krishnan, James Scott Moncrief, Christal Mickle, Christopher Lauderback, Thomas Piccariello
  • Publication number: 20080090771
    Abstract: The invention relates to compounds, compositions and methods comprised of a chemical moiety attached to hydrocodone. The invention provides embodiments that provide a decrease in the potential of hydrocodone to cause overdose or to be abused while still delivering therapeutic activity similar to that of the parent hydrocodone. The invention also provides methods of delivering hydrocodone as conjugates that release the hydrocodone following oral administration while being resistant to abuse by other routes such as intravenous injection (“shooting”) and intranasal administration (“snorting”). Further, hydrocodone compositions of the invention are resistant to oral abuse as well, since release of the hydrocodone at suprapharmacological doses reaches saturation.
    Type: Application
    Filed: October 8, 2007
    Publication date: April 17, 2008
    Applicant: SHIRE LLC
    Inventor: James Moncrief
  • Publication number: 20070264323
    Abstract: A multiple pulsed dose drug delivery system for pharmaceutically active amphetamine salts, comprising a pharmaceutically active amphetamine salt covered with an immediate-release coating and a pharmaceutically active amphetamine salt covered with an enteric coating wherein the immediate release coating and the enteric coating provide for multiple pulsed dose delivery of the pharmaceutically active amphetamine salt. The product can be composed of either one or a number of beads in a dosage form, including either capsule, tablet, or sachet method for administering the beads.
    Type: Application
    Filed: May 12, 2006
    Publication date: November 15, 2007
    Applicant: SHIRE LLC
    Inventors: Amir Shojaei, Stephanie Read, Richard Couch, Paul Hodgkins