Abstract: Disclosed are methods of treatment of various conditions and disorders, and symptoms associated therewith, including, for example, fatigue and/or inattention associated with various conditions and disorders, using homoarginine-amphetamine prodrug and/or conjugate, or salts thereof.
Type:
Application
Filed:
April 10, 2018
Publication date:
May 21, 2020
Applicant:
Shire Pharmaceuticals Inc.
Inventors:
Brigitte A. ROBERTSON, Norman W. BARTON
Abstract: The present invention concerns prodrugs of opioid analgesics and pharmaceutical compositions containing such prodrugs. Methods for providing more consistent pain relief by increasing the bioavailability of the opioid analgesic with the aforementioned prodrugs are provided. The invention also provides for decreasing the adverse GI side effects of opioid analgesics.
Type:
Application
Filed:
December 23, 2010
Publication date:
August 4, 2011
Applicant:
Shire Pharmaceuticals, Inc.
Inventors:
Richard Franklin, Karl Swift, Bernard T. Golding, Robert G. Tyson
Abstract: A delivery system for the delivery of a salt of meptazinol or meptazinol precursor which increases the bioavailability of meptanizol by an effective amount to provide analgesic relief is disclosed. One embodiment of the delivery system is a transdermal device which increases the skin flux of meptazinol by an effective amount to provide analgesic relief. Also disclosed are methods of providing analgesic relief.