Abstract: Systems and methods are provided for management of bio-fuel production research and development, comprising (1) mapping process template layers into process segments, wherein each process template layer specifies configuration of a bio-fuel manufacturing process via process segments, and wherein each process segment specifies a stage of the bio-fuel manufacturing process via a grouping of segment modules, (2) recording specified data at each segment module, wherein the specified data includes input data, output data, and environment data, (3) configuring workflow through each process segment according to the segment modules within respective process segments, and wherein the workflow specifies the segment modules that are present and the order of the segment modules, and (4) providing the specified data to a research and development lifecycle management module for determination of results based on tracking and comparison of specified data, and wherein segment modules are modified based on the determined resul