Abstract: The present intraoral sensing apparatus is configured to be installed in an oral cavity, and is provided with an electronic device equipped with electronic components mounted on a circuit board; a first dental resin material which completely covers the electronic device; a second dental resin material which completely covers the first dental resin material; and an intraoral instrument having a first recess in which the electronic device covered with the first dental resin material and the second dental resin material is accommodated.

Abstract: Provided is a method for treating a disease in which Hic-5 participates. A composition comprising a Hic-5 inhibitor, said composition being for treating a disease selected from among cardiomegaly, interstitial pneumonia, osteoarthritis, fatty liver and tumor, or for inhibiting vascular invasion of cancer cells.

Abstract: An endoscope observation assistance apparatus includes an image information acquiring part to acquire and display a captured image of a luminal organ captured by the endoscope device on a display, a lesion information acquisition part to detect a predetermined lesion based on the captured image and to acquire lesion information regarding the lesion, a lesion disappearance determination part to track the lesion based on the captured image and the lesion information and to determine whether or not the lesion has disappeared from the captured image, and a notification part to notify a determination result when the lesion disappearance determination part determines that the lesion has disappeared from the captured image. Alternatively, the notification part may notify a lesion detection when a short time period passes after the lesion detection by the lesion information acquisition part.

Abstract: An object to allow an automatic discrimination between a super enlarged image and a non-enlarged image in a computer diagnosis assistance system that analyzes a state of an epithelium using an image analysis. An image analyzing device according to this disclosure is the image analyzing device to be connected to an endoscope, and includes a target image determination unit that obtains an image from the endoscope and determines whether or not the image is a target image using a halation region included in the image, and an image analyzing unit that analyzes a state of an epithelium, captured by the endoscope, using the target image when the image is the target image.

Abstract: The present invention provides a compound having a dihydropyran structure, a method of producing a compound having a dihydropyran structure, a method of producing Pre-SMTP, a method of producing a group of SMTPs, and a pharmaceutical composition. The compound having a dihydropyran structure can be a useful intermediate in the chemically producing a group of Pre-SMTP and SMTP. Specifically, the compound having a dihydropyran structure is represented by the following formula (1), wherein: R3Si is a silyl group selected from TMS: trimethylsilyl, TES: triethysilyl, TBS (TBDMS): tert-butyldimethylsil, TIPS: triisopropylsilyl, TBDPS: tert-butyldiphenylsilyl, X is selected from COOH, CHO, and —CH?C(CH3)—(CH2)2—CH?C(CH3)2.

Abstract: This invention relates to an analgesic drug comprising a compound represented by the following formula (I) or (II), wherein R1 is a C1-6-alkoxy group or a C1-6-haloalkoxy group; R2 is a hydrogen atom; and R is an indazolyl group substituted with a halogen atom; a substituted or unsubstituted phenyl group; a pyrazolyl group; or a substituted or unsubstituted aralkyl group; or a salt thereof, or a solvate thereof.

Abstract: A biometric information detection device according to one embodiment of the present disclosure is configured to be installed in a living body, and includes a sensor, a battery, a mechanical switch, a sealing member, and a holding member. The mechanical switch switches between a conduction state in which power is supplied from the battery to the sensor and a cutoff state in which supply of the power is blocked. The sealing member seals all of the sensor, the battery, and the mechanical switch. The holding member is attached to the living body and holds the sealing member.

Abstract: A non-transitory computer-readable recording medium stores therein an examination assisting program that causes a computer to execute a process including: performing a site detecting process that uses an object detection technique on each of a plurality of ultrasound examination images taken of an examined subject by performing a scan on the examined subject; and displaying a site detection map in which a detection result of each of a plurality of sites included in the examined subject is kept in correspondence with the scan, on a basis of detection results from the site detecting process.

Abstract: A non-transitory computer-readable recording medium storing therein an anomalousness determination program that causes a computer to execute a process includes: sensing a region in an object in each of a plurality of ultrasound examination images using an object sensing technique; based on a result of the sensing and a structure of the object, acquiring a result of sensing each of a plurality of regions in the object in each of the ultrasound examination images; and determining anomalousness in the object based on the result of sensing each of the regions in the ultrasound examination images.

Abstract: This invention relates to an analgesic drug comprising a compound represented by the following formula (I) or (II), wherein R1 is a C1-6-alkoxy group or a C1-6-haloalkoxy group; R2 is a hydrogen atom; and R is an indazolyl group substituted with a halogen atom; a substituted or unsubstituted phenyl group; a pyrazolyl group; or a substituted or unsubstituted aralkyl group; or a salt thereof, or a solvate thereof.

Abstract: A drug for renal disease, the drug including a compound represented by the following Formula (I) as an active ingredient.

Abstract: A detection method of detecting CTCs as target cells contained in a test sample, the method includes a concentration step of concentrating the target cells contained in the test sample, a labeling step of labeling the target cells and other components by bringing the concentrated test sample into contact with first labeling antibodies in which antibodies specifically binding to antigens, which exclude antigens expressing in epithelial cells and specifically express in the target cells, are labeled by a first labeling substance, and into contact with second labeling antibodies in which antibodies binding to antigens expressing in the other components excluding the target cells are labeled by a second labeling substance, and a detection step of detecting, from the test sample, cells that are labeled by the first labeling antibodies and are not labeled by the second labeling antibodies as the target cells.

Abstract: The present invention provides a compound having a dihydropyran structure, a method of producing a compound having a dihydropyran structure, a method of producing Pre-SMTP, a method of producing a group of SMTPs, and a pharmaceutical composition. The compound having a dihydropyran structure can be a useful intermediate in the chemically producing a group of Pre-SMTP and SMTP. Specifically, the compound having a dihydropyran structure is represented by formula (1), wherein: R3Si is a silyl group selected from TMS: trimethylsilyl, TES: triethysilyl, TBS (TBDMS): tert-butyldimethylsil, TIPS: triisopropylsilyl, TBDPS: tert-butyldiphenylsilyl, X is selected from COOH, CHO, and —CH?C(HCH3)—(CH2)2—CH?C(CH3)2.

Abstract: Provided is a dental ultrasonic cleaning device that efficiently cleans teeth or dentures in an oral cavity using ultrasonic waves. A dental ultrasonic cleaning device 1 emits ultrasonic waves through a cleaning-liquid (W1) to the surface of a cleaning-target 26, ultrasonically cleaning it. An ultrasonic horn 24 propagates ultrasonic waves being generated by an ultrasonic-wave transducer 23 and emits them from the vibratory surface 25 provided at the tip-end of the horn 24. A liquid-reserving part 27 is provided, surrounding the vibratory surface 25 of the ultrasonic horn 24, which temporarily reserves the cleaning-liquid (W1) between the vibratory surface 25 and the cleaning-target 26. A cap-member 33 is provided at a certain interval opposite the liquid-reserving part 27.

Abstract: This invention is achieved to provide a water-flow ultrasonic oral-cavity cleaning device. In the water-flow ultrasonic oral-cavity cleaning device (1), cleaning liquid (W1) from a cleaning-liquid supplying device (2) is supplied into a transducer case (21) through a supply port (26). Ultrasonic waves (S1) are propagated into the cleaning liquid W1 from an ultrasonic transducer (22) mounted in a transducer mounting part (23) inside the transducer case (21). The water-flow of the cleaning liquid (W1) is collected at the apical-part inside the transducer case (21), and then emitted from the issue (27) into the oral cavity, wherein power supply of 100W or less is supplied to the ultrasonic transducer (22) of 50 mm or less in diameter to propagate the ultrasonic waves (S1) of 100 kHz or more to 3 MHz or less in frequency into the cleaning liquid (W1).

Abstract: It is possible to provide a small intestine endoscope training simulator (11) which allows to obtain a feeling similar to that of inserting an endoscope (38) into the small intestine (34) of the living body (30) and learn the actual operation of the endoscope (38). This training simulator (11) includes a plurality of longitudinal elastic members (32) for applying an elastic force to each of a plurality of portions of a simulated small intestine (13). One end portion sides of the plurality of longitudinal elastic members (32) are respectively attached to the first attachment portions (27) on the simulated small intestine (13) side. The other end portion sides of the plurality of longitudinal elastic members (32) are respectively attached to the second attachment portions (33, 57) on the case (12) side.

Abstract: Disclosed is a cytoprotective agent for use with respect to ischemic damage, including as an active ingredient a triprenyl phenol compound represented by the following general formula (I), wherein X is —CHY—C(CH3)2Z, Y and Z are each independently —H or —OH, or jointly form a single bond, and R represents a hydrogen atom or a substituent with a molecular weight of 1000 or less.

Abstract: The object of the present invention is to provide a food product for enhancing chewing ability having hardness, viscosity and so on suitable for the mouth of a small child from the age of one year to five years and eleven months, in particular a young child in the age of approximately one and one-half years who can utilize teeth for chewing after weaning. The food product for enhancing chewing ability of the present invention contains at least one type of main raw material selected from the flour group consisting of wheat flour, rice flour and starchy flour, and at least one type of secondary raw material selected from the group consisting of sorbitol and glycerol. This food product for enhancing chewing ability preferably has a breaking stress, breaking strain, brittleness stress and cohesiveness within predetermined ranges.

Abstract: This invention is achieved to provide a water-flow ultrasonic oral-cavity cleaning device and a method for water-flow ultrasonic oral-cavity cleaning for surely and efficiently cleaning an oral cavity. In the water-flow ultrasonic oral-cavity cleaning device 1, cleaning liquid W1 from a cleaning-liquid supplying device 2 is supplied into a transducer case 21 through a supply port 26. Ultrasonic waves S1 are propagated into the cleaning liquid W1 from an ultrasonic transducer 22 mounted in a transducer mounting part 23 inside the transducer case 21. The water-flow of the cleaning liquid W1 is collected at the apical-part inside the transducer case 21, and then emitted from the issue 27 into the oral cavity, wherein power supply of 100W or less is supplied to the ultrasonic transducer 22 of 50 mm or less in diameter to propagate the ultrasonic waves S1 of 100 kHz or more to 3 MHz or less in frequency into the cleaning liquid W1.

Abstract: A device for cleaning oral cavity and a method for cleaning oral cavity capable of cleaning stains such as plaque, tartar, and the like even in a narrow portion such as a clearance between teeth, a clearance between implants, and the like. A cover includes a jetting orifice and a discharge orifice and covers a tooth by leaving a clearance between the tooth and the cover so that the clearance can hold water. A jetting unit is mounted in the jetting orifice and includes a flow path communicating with the clearance between the tooth and the cover. The jetting unit is configured to generate cavitation bubbles. The flow path includes a small diameter part and an enlarged part. A discharge unit discharges water in the clearance between the tooth and the cover from the discharge orifice.