Patents Assigned to Shriners Hospitals for Children
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Publication number: 20140287020Abstract: A device, and method of making the device, capable of therapeutic treatment and/or for in vitro testing of human skin. The device may be used on skin wounds for burned, injured, or diseased skin, and provides structures and functions as in normal uninjured skin, such as barrier function, which is a definitive property of normal skin. The device contains cultured dermal and epidermal cells on a biocompatible, biodegradable reticulated matrix. All or part of the cells may be autologous, from the recipient of the cultured skin device, which advantageously eliminates concerns of tissue compatibility. The cells may also be modified genetically to provide one or more factors to facilitate healing of the engrafted skin replacement, such as an angiogenic factor to stimulate growth of blood vessels.Type: ApplicationFiled: June 9, 2014Publication date: September 25, 2014Applicants: University of Cincinnati, Shriners Hospitals for ChildrenInventor: Steven T. Boyce
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Patent number: 8821588Abstract: Anchoring system for a prosthetic or orthotic device includes a fastener comprising a base and a clasp-engaging member, wherein the fastener further comprises an adhesive to secure the base directly to skin of a wearer; and a clasp comprising a first end configured to engage and rotate about the clasp-engaging member and a second end configured to engage the activation cable of a prosthetic or orthotic device. Also included is a prosthetic or orthotic system that includes the anchoring system in combination with a prosthetic or orthotic device, as well as a method of securing a prosthetic or orthotic device on a wearer using the anchoring system.Type: GrantFiled: December 3, 2012Date of Patent: September 2, 2014Assignee: Shriners Hospitals for ChildrenInventor: Debra Ann Latour
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Publication number: 20140213474Abstract: Provided here in are, inter alia, methods of determining whether a patient is resistant or sensitive to glucocorticoid therapy.Type: ApplicationFiled: March 11, 2014Publication date: July 31, 2014Applicant: Shriners Hospitals for ChildrenInventors: Kiho Cho, David G. Greenhalgh
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Patent number: 8765468Abstract: A device, and method of making the device, capable of therapeutic treatment and/or for in vitro testing of human skin. The device may be used on skin wounds for burned, injured, or diseased skin, and provides structures and functions as in normal uninjured skin, such as barrier function, which is a definitive property of normal skin. The device contains cultured dermal and epidermal cells on a biocompatible, biodegradable reticulated matrix. All or part of the cells may be autologous, from the recipient of the cultured skin device, which advantageously eliminates concerns of tissue compatibility. The cells may also be modified genetically to provide one or more factors to facilitate healing of the engrafted skin replacement, such as an angiogenic factor to stimulate growth of blood vessels.Type: GrantFiled: May 24, 2013Date of Patent: July 1, 2014Assignees: University of Cincinnati, Shriners Hospitals for ChildrenInventor: Steven T. Boyce
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Patent number: 8768497Abstract: The present application describes, inter alia, methods, devices, and systems for modeling and fabricating corrective appliances and methods of treating cleft palate using same.Type: GrantFiled: February 27, 2009Date of Patent: July 1, 2014Assignee: Shriners Hospitals for ChildrenInventors: Philip B. Stoddard, Beth A. Roscoe
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Patent number: 8663937Abstract: The instant invention relates to the use of 24-hydroxylated vitamin D compounds as therapeutics in mammalian bone fracture repair. In addition, the instant invention relates to novel 24-hydroxylated vitamin D compound receptors which can be employed in the development of compounds capable of facilitating fracture repair in animals. The instant invention also relates to nucleic acids encoding such receptors as well as vectors, host cells, transgenic animals comprising such nucleic acids and screening assays employing such receptors.Type: GrantFiled: May 30, 2013Date of Patent: March 4, 2014Assignee: Shriners Hospital For ChildrenInventor: Rene St-Arnaud
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Patent number: 8663986Abstract: The instant invention relates to the use of 24-hydroxylated vitamin D compounds as therapeutics in mammalian bone fracture repair. In addition, the instant invention relates to novel 24-hydroxylated vitamin D compound receptors which can be employed in the development of compounds capable of facilitating fracture repair in animals. The instant invention also relates to nucleic acids encoding such receptors as well as vectors, host cells, transgenic animals comprising such nucleic acids and screening assays employing such receptors.Type: GrantFiled: November 29, 2011Date of Patent: March 4, 2014Assignee: Shriners Hospital For ChildrenInventor: Rene St-Arnaud
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Patent number: 8663934Abstract: The instant invention relates to the use of 24-hydroxylated vitamin D compounds as therapeutics in mammalian bone fracture repair. In addition, the instant invention relates to novel 24-hydroxylated vitamin D compound receptors which can be employed in the development of compounds capable of facilitating fracture repair in animals. The instant invention also relates to nucleic acids encoding such receptors as well as vectors, host cells, transgenic animals comprising such nucleic acids and screening assays employing such receptors.Type: GrantFiled: May 30, 2013Date of Patent: March 4, 2014Assignee: Shriners Hospital for ChildrenInventor: Rene St-Arnaud
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Patent number: 8658854Abstract: The instant invention relates to the use of 24-hydroxylated vitamin D compounds as therapeutics in mammalian bone fracture repair. In addition, the instant invention relates to novel 24-hydroxylated vitamin D compound receptors which can be employed in the development of compounds capable of facilitating fracture repair in animals. The instant invention also relates to nucleic acids encoding such receptors as well as vectors, host cells, transgenic animals comprising such nucleic acids and screening assays employing such receptors.Type: GrantFiled: May 30, 2013Date of Patent: February 25, 2014Assignee: Shriners Hospital For ChildrenInventor: Rene St-Arnaud
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Publication number: 20130337149Abstract: A material derived from sea cucumber collagen fibrils is suitable for use in corneal replacements or as an implantable contact lens. To produce material, the collagen fibrils are centrifuged into orthogonal stacks of lamellae comprised of aligned fibrils. The resulting structure is a transparent film of arbitrary thickness very similar in structure to mammalian corneal tissue.Type: ApplicationFiled: August 20, 2013Publication date: December 19, 2013Applicants: Shriners Hospitals for Children, University of South FloridaInventors: W. Garrett Matthews, August Heim, Thomas J. Koob
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Publication number: 20130252250Abstract: The instant invention relates to the use of 24-hydroxylated vitamin D compounds as therapeutics in mammalian bone fracture repair. In addition, the instant invention relates to novel 24-hydroxylated vitamin D compound receptors which can be employed in the development of compounds capable of facilitating fracture repair in animals. The instant invention also relates to nucleic acids encoding such receptors as well as vectors, host cells, transgenic animals comprising such nucleic acids and screening assays employing such receptors.Type: ApplicationFiled: May 30, 2013Publication date: September 26, 2013Applicant: Shriners Hospital For ChildrenInventor: Rene St-Arnaud
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Publication number: 20130254910Abstract: The instant invention relates to the use of 24-hydroxylated vitamin D compounds as therapeutics in mammalian bone fracture repair. In addition, the instant invention relates to novel 24-hydroxylated vitamin D compound receptors which can be employed in the development of compounds capable of facilitating fracture repair in animals. The instant invention also relates to nucleic acids encoding such receptors as well as vectors, host cells, transgenic animals comprising such nucleic acids and screening assays employing such receptors.Type: ApplicationFiled: May 30, 2013Publication date: September 26, 2013Applicant: Shriners Hospital For ChildrenInventor: Rene St-Arnaud
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Publication number: 20130252252Abstract: The instant invention relates to the use of 24-hydroxylated vitamin D compounds as therapeutics in mammalian bone fracture repair. In addition, the instant invention relates to novel 24-hydroxylated vitamin D compound receptors which can be employed in the development of compounds capable of facilitating fracture repair in animals. The instant invention also relates to nucleic acids encoding such receptors as well as vectors, host cells, transgenic animals comprising such nucleic acids and screening assays employing such receptors.Type: ApplicationFiled: May 30, 2013Publication date: September 26, 2013Applicant: Shriners Hospital For ChildrenInventor: Rene St-Arnaud
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Patent number: 8518306Abstract: A material derived from sea cucumber collagen fibrils is suitable for use in corneal replacements or as an implantable contact lens. To produce material, the collagen fibrils are centrifuged into orthogonal stacks of lamellae comprised of aligned fibrils. The resulting structure is a transparent film of arbitrary thickness very similar in structure to mammalian corneal tissue.Type: GrantFiled: May 13, 2011Date of Patent: August 27, 2013Assignees: University of South Florida, Shriners Hospitals for ChildrenInventors: W. Garrett Matthews, August Heim, Thomas J. Koob
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Publication number: 20130157257Abstract: The present invention relates to the newly identified timerization initiating and stagger determining capacity of the NC2 domain of collagen IX. The invention further relates to a hexavalent molecular building block wherein the linkage of additional moieties to the amino and carboxyl terminals of monomers comprising the NC2 domain of collagen IX promotes the directed association of those moieties via the trimerization initiating and stagger determining capacity of the NC2 domain of collagen IX.Type: ApplicationFiled: November 23, 2012Publication date: June 20, 2013Applicant: Shriners Hospital for ChildrenInventor: Hans Peter Bachinger
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Patent number: 8450108Abstract: A device, and method of making the device, capable of therapeutic treatment and/or for in vitro testing of human skin. The device may be used on skin wounds for burned, injured, or diseased skin, and provides structures and functions as in normal uninjured skin, such as barrier function, which is a definitive property of normal skin. The device contains cultured dermal and epidermal cells on a biocompatible, biodegradable reticulated matrix. All or part of the cells may be autologous, from the recipient of the cultured skin device, which advantageously eliminates concerns of tissue compatibility. The cells may also be modified genetically to provide one or more factors to facilitate healing of the engrafted skin replacement, such as an angiogenic factor to stimulate growth of blood vessels.Type: GrantFiled: June 18, 2010Date of Patent: May 28, 2013Assignees: University of Cincinnati, Shriners Hospitals for ChildrenInventor: Steven T. Boyce
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Patent number: 8426396Abstract: The present application provides, inter alia, methods of treating disorders mediated by FGFRs and methods of screening for Hsp90 inhibitor compounds.Type: GrantFiled: January 8, 2009Date of Patent: April 23, 2013Assignee: Shriners Hospitals for ChildrenInventors: William A. Horton, Melanie B. Laederich
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Publication number: 20130090743Abstract: Anchoring system for a prosthetic or orthotic device includes a fastener comprising a base and a clasp-engaging member, wherein the fastener further comprises an adhesive to secure the base directly to skin of a wearer; and a clasp comprising a first end configured to engage and rotate about the clasp-engaging member and a second end configured to engage the activation cable of a prosthetic or orthotic device. Also included is a prosthetic or orthotic system that includes the anchoring system in combination with a prosthetic or orthotic device, as well as a method of securing a prosthetic or orthotic device on a wearer using the anchoring system.Type: ApplicationFiled: December 3, 2012Publication date: April 11, 2013Applicant: Shriners Hospital For ChildrenInventor: Shriners Hospital For Children
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Patent number: 8323355Abstract: Anchoring system for a cable-activated prosthetic or orthotic device includes a fastener comprising a base and a clasp-engaging member, wherein the fastener further comprises an adhesive to secure the base directly to skin of a wearer; and a clasp comprising a first end configured to engage and rotate about the clasp-engaging member and a second end configured to engage the activation cable of a prosthetic or orthotic device. Also included is a prosthetic or orthotic system that includes the anchoring system in combination with a prosthetic or orthotic device comprising an activation cable and a terminal device, wherein the activation cable comprises a first end operatively coupled to the terminal device and a second end engaged with the second end of the clasp.Type: GrantFiled: March 28, 2011Date of Patent: December 4, 2012Assignee: Shriners Hospitals For ChildrenInventor: Debra Ann Latour
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Publication number: 20120289866Abstract: The present disclosure relates to a system for collecting gait analysis data for analysis. The system may utilize force plate or balance boards as well as strain gauge force measurements to improve physical therapy and gait analysis for patients that use physical supports to walk or stand. The device measures force applied to the floor and to handrails to provide data on the patient's use of aid, e.g., the handrail, while standing or walking For physical therapy implementations, the system may also be combined with a game or other visual interface that provides feedback to the patient and/or to the caregiver.Type: ApplicationFiled: April 13, 2012Publication date: November 15, 2012Applicants: Shriners Hospital for Children, William Marsh Rice UniversityInventors: Steven E. Irby, Z. Maria Oden, Matthew K. Jones, Marcia K. O'Malley, Michele Lynn Pyle, Andrew S. Berger, Judith Lynn Linton