Abstract: Methods and formulations are provided for treating cancer and neoplastic diseases in conjunction with radiation therapy where such methods and formulations include a combination of a radiosensitizing agent that is metabolized by thymidine phosphorylase and a thymidine phosphorylase inhibitor that increases the half-life of the radiosensitizing agent.
Type:
Grant
Filed:
December 4, 2023
Date of Patent:
July 15, 2025
Assignee:
Shuttle Pharmaceuticals, Inc.
Inventors:
Scott Grindrod, Mira Jung, Olga Timofeeva, Milton Brown, Anatoly Dritschilo
Abstract: Selective HDAC inhibitors, and pharmaceutical compositions that include the same, are described herein for the treatment of cancer, immunological diseases, inflammatory diseases, and neurological diseases.
Type:
Grant
Filed:
June 28, 2022
Date of Patent:
September 3, 2024
Assignee:
Shuttle Pharmaceuticals, Inc.
Inventors:
Scott Grindrod, Mira Jung, Anatoly Dritschilo
Abstract: Methods and formulations are provided for treating cancer and neoplastic diseases in conjunction with radiation therapy where such methods and formulations include a combination of a radiosensitizing agent that is metabolized by thymidine phosphorylase and a thymidine phosphorylase inhibitor that increases the half-life of the radiosensitizing agent.
Type:
Grant
Filed:
January 9, 2018
Date of Patent:
May 23, 2023
Assignee:
Shuttle Pharmaceuticals, Inc.
Inventors:
Scott Grindrod, Mira Jung, Olga Timofeeva, Milton Brown, Anatoly Dritschilo
Abstract: Selective HDAC inhibitors, and pharmaceutical compositions that include the same, are described herein for the treatment of cancer, immunological diseases, inflammatory diseases, and neurological diseases.
Type:
Grant
Filed:
May 10, 2021
Date of Patent:
February 21, 2023
Assignee:
Shuttle Pharmaceuticals, Inc.
Inventors:
Scott Grindrod, Mira Jung, Milton Brown, Anatoly Dritschilo
Abstract: Selective HDAC inhibitors, and pharmaceutical compositions that include the same, are described herein for the treatment of cancer, immunological diseases, inflammatory diseases, and neurological diseases.
Type:
Grant
Filed:
January 8, 2019
Date of Patent:
August 9, 2022
Assignee:
Shuttle Pharmaceuticals, Inc.
Inventors:
Scott Grindrod, Mira Jung, Anatoly Dritschilo
Abstract: Selective HDAC inhibitors, and pharmaceutical compositions that include the same, are described herein for the treatment of cancer, immunological diseases, inflammatory diseases, and neurological diseases.
Type:
Grant
Filed:
January 9, 2018
Date of Patent:
June 15, 2021
Assignee:
Shuttle Pharmaceuticals, Inc.
Inventors:
Scott Grindrod, Mira Jung, Milton Brown, Anatoly Dritschilo
Abstract: Dual function compounds are provided that may be inhibitors of histone deacetylase (HDAC) and activators of ataxia telangiectasia mutated (ATM). Pharmaceutical compositions and methods of use are also provided that utilize such compounds.
Type:
Grant
Filed:
March 3, 2016
Date of Patent:
August 18, 2020
Assignee:
Shuttle Pharmaceuticals, Inc.
Inventors:
Scott Grindrod, Mira Jung, Milton Brown, Anatoly Dritschilo
Abstract: Dual function compounds are provided that may be inhibitors of histone deacetylase (HDAC) and activators of ataxia telangiectasia mutated (ATM). Pharmaceutical compositions and methods of use are also provided that utilize such compounds.
Type:
Grant
Filed:
November 6, 2017
Date of Patent:
August 4, 2020
Assignee:
Shuttle Pharmaceuticals, Inc.
Inventors:
Scott Grindrod, Mira Jung, Milton Brown, Anatoly Dritschilo