Abstract: The present invention provides glycan-interacting antibodies and methods for producing glycan-interacting antibodies useful in the treatment and prevention of human disease, including cancer. Such glycan-interacting antibodies include monoclonal antibodies, derivatives, and fragments thereof as well as compositions and kits comprising them. Further provided are methods of using glycan-interacting antibodies to target cells and treat disease.
Abstract: The present invention provides glycan-interacting antibodies and methods for producing glycan-interacting antibodies useful in the treatment and prevention of human disease, including cancer. Such glycan-interacting antibodies include monoclonal antibodies, derivatives and fragments thereof as well as compositions and kits comprising them.
Type:
Application
Filed:
October 10, 2014
Publication date:
September 15, 2016
Applicant:
SIAMAB THERAPEUTICS, INC.
Inventors:
Ana Paula Galvao da Silva, Mai Zhang, Darius Ghaderi, Intan Purnajo, Julie DeSander, Jeffrey Behrens
Abstract: The invention provides sialylated glycans and antibodies that specifically bind to them. The invention's compositions and methods for using them are useful for early detection and diagnosis of cancer.
Type:
Grant
Filed:
December 23, 2013
Date of Patent:
August 23, 2016
Assignees:
The Regents of the University of California, Siamab Therapeutics, Inc.
Inventors:
Ajit Varki, Richard B. Schwab, Vered Padler-Karavani, Nancy Hurtado-Ziola
Abstract: The present invention provides glycan-interacting antibodies useful in the treatment and prevention of human disease, including cancer. Such glycan-interacting antibodies include monoclonal antibodies, derivatives and fragments thereof as well as compositions and kits comprising them.
Type:
Grant
Filed:
January 21, 2016
Date of Patent:
August 16, 2016
Assignee:
Siamab Therapeutics, Inc.
Inventors:
Darius Ghaderi, Ana Paula Galvao da Silva
Abstract: Embodiments of the present invention provide compositions and methods for the modulation of sialic acid levels. In some embodiments, compositions disclosed herein comprise nutraceuticals as functional agents.
Type:
Application
Filed:
May 29, 2014
Publication date:
April 21, 2016
Applicant:
SIAMAB THERAPEUTICS, INC.
Inventors:
Mai Zhang, Darius Ghaderi, Jeffrey Behrens, Julie DeSander, Ajit Varki
Abstract: The present invention provides glycan-interacting antibodies useful in the treatment and prevention of human disease, including cancer. Such glycan-interacting antibodies include monoclonal antibodies, derivatives and fragments thereof as well as compositions and kits comprising them.
Type:
Grant
Filed:
October 10, 2013
Date of Patent:
March 1, 2016
Assignee:
SIAMAB THERAPEUTICS, INC.
Inventors:
Darius Ghaderi, Ana Paula Galvao da Silva