Patents Assigned to Sibia Neurosciences Inc.
  • Pyridine derivatives
    Patent number: 6656957
    Abstract: A compound of formula I wherein X represents an optionally halo-substituted (C2-4)alkynylene group bonded via vicinal unsaturated carbon atoms.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: December 2, 2003
    Assignees: Novartis AG, Sibia Neurosciences Inc.
    Inventors: Hans Allgeier, Yves Auberson, Michel Biollaz, Nicholas David Cosford, Fabrizio Gasparini, Roland Heckendorn, Edwin Carl Johnson, Rainer Kuhn, Mark Andrew Varney, Gönül Veliçelebi
  • Methods of treating neurodegenerative disorders using protease inhibitors
    Patent number: 6051684
    Abstract: Methods of use of compounds for the treatment of disorders characterized by the cerebral deposition of amyloid are provided. Among the compounds provided for use in the methods are those of the formula: ##STR1## in which R.sub.1 is preferably 2-methylpropenyl, 2-butenyl, cyclohexyl or cyclohexylmethyl; R.sub.2, R.sub.4, and R.sub.8 are each preferably independently methyl or ethyl; R.sub.3 is preferably iso-butyl or phenyl; R.sub.5 is preferably iso-butyl; R.sub.6 is preferably H or methyl; R.sub.7 --(Q).sub.n is preferably benzyloxycarbonyl or acetyl; Q is preferably --C(O)--; and X is preferably an aldehyde, .alpha.-ketoester or .alpha.-ketoamide.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: April 18, 2000
    Assignee: SIBIA Neurosciences Inc.
    Inventors: Ian Alexander McDonald, Elisabeth Albrecht, Benito Munoz