Abstract: Provided are crystalline forms of N-[4-[2-(2-amino-4, 7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]ben-zoyl]-L-glutamic acid, pemetrexed diacid, and processes for the preparation thereof.
Type:
Grant
Filed:
November 23, 2016
Date of Patent:
August 1, 2017
Assignee:
Sicor Inc.
Inventors:
Jonathan Busolli, Nicola Diulgheroff, Csilla Nemethne Racz, Moran Pirkes, Alessandro Pontiroli, Marco Villa, Judith Aronhime
Abstract: Provided are crystalline forms of N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]ben-zoyl]-L-glutamic acid, pemetrexed diacid, and processes for the preparation thereof.
Type:
Grant
Filed:
September 16, 2015
Date of Patent:
February 7, 2017
Assignee:
Sicor, Inc.
Inventors:
Jonathan Busolli, Nicola Diulgheroff, Csilla Nemethne Racz, Moran Pirkes, Alessandro Pontiroli, Marco Villa, Judith Aronhime
Abstract: Provided are crystalline forms of N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, pemetrexed diacid, and processes for the preparation thereof.
Type:
Grant
Filed:
March 23, 2011
Date of Patent:
October 13, 2015
Assignee:
Sicor Inc.
Inventors:
Jonathan Busolli, Nicola Diulgheroff, Csilla Nemethne Racz, Moran Pirkes, Alessandro Pontiroli, Marco Villa, Judith Aronhime
Abstract: This invention relates to novel crystalline forms of tiotropium bromide, processes for preparing them, and their use in pharmaceutical formulations.
Abstract: This invention relates to novel crystalline forms of tiotropium bromide, processes for preparing them, and their use in pharmaceutical formulations.
Abstract: Provided are processes for the preparation of lyophilized pharmaceutically acceptable salts of pemetrexed diacid, in particular, pemetrexed disodium salt, directly from pemetrexed diacid or salts thereof, i.e., without isolating the obtained pemetrexed salt prior to lyophilizing it.
Type:
Grant
Filed:
August 14, 2007
Date of Patent:
January 14, 2014
Assignee:
Sicor, Inc.
Inventors:
Jonathan Busolli, Nicola Diulgheroff, Moran Pirkes, Alessandro Pontiroli, Marco Villa, Zvi Harel
Abstract: This invention relates to novel crystalline forms of tiotropium bromide, processes for preparing them, and their use in pharmaceutical formulations.
Abstract: This invention relates to novel crystalline forms of tiotropium bromide, processes for preparing them, and their use in pharmaceutical formulations.
Abstract: This invention relates to novel crystalline forms of tiotropium bromide, processes for preparing them, and their use in pharmaceutical formulations.
Abstract: Provided are crystalline forms of N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, pemetrexed diacid, and processes for the preparation thereof.
Type:
Grant
Filed:
August 14, 2007
Date of Patent:
January 3, 2012
Assignee:
Sicor Inc.
Inventors:
Jonathan Busolli, Nicola Diulgheroff, Csilla Nemethne Racz, Moran Pirkes, Alessandro Pontiroli, Marco Villa, Judith Aronhime
Abstract: Solvates and crystalline forms of imatinib mesylate are described. Further, methods for preparing such solvates and crystalline forms of imatinib mesylate are described.
Type:
Grant
Filed:
April 27, 2007
Date of Patent:
November 29, 2011
Assignee:
Sicor Inc.
Inventors:
Alexandr Jegorov, Miloslav Chudík, Judith Aronhime, Ale{hacek over (s)} Gavenda, Ji{hacek over (r)}í Faustmann
Abstract: Provided are crystalline forms of N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, pemetrexed diacid, and processes for the preparation thereof.
Type:
Application
Filed:
March 23, 2011
Publication date:
August 11, 2011
Applicant:
SICOR INC.
Inventors:
Jonathan BUSOLLI, Nicola DIULGHEROFF, Csilla Nemethne Racz, Moran PIRKES, Alessandro PONTIROLI, Marco VILLA, Judith ARONHIME
Abstract: Solvates and crystalline forms of imatinib mesylate are described. Further, methods for preparing such solvates and crystalline forms of imatinib mesylate are described. The structure diagram below shows the chemical structure of imatinib mesylate.
Type:
Grant
Filed:
April 17, 2008
Date of Patent:
July 12, 2011
Assignee:
Sicor Inc.
Inventors:
Alexandr Jegorov, Miloslav Chudík, Judith Aronhime, Ale{hacek over (s)} Gavenda, Ji{hacek over (r)}í Faustmann