Patents Assigned to Sicor Societa' Italiana Corticosteroida S.p.A.
  • Process for the preparation of anthracycline antibiotics
    Patent number: 5945518
    Abstract: A process for the preparation of antibiotics of the anthracycline class of formula (A), wherein R.sup.1 is hydrogen, OH, or OCOR.sup.2, wherein R.sup.2 is a C.sub.1 -C.sub.4 -alkyl group; which comprises the epimerization of the 4' hydroxy group of the daunosamine residue by nucleophilic substitution of a triflate group with a carboxylate, which epimerization is carried out on the whole molecule with the hydroxy groups being protected, and subsequent transformation into the final product.
    Type: Grant
    Filed: September 18, 1997
    Date of Patent: August 31, 1999
    Assignee: Sicor Societa' Italiana Corticosteroida S.p.A.
    Inventors: Ettore Bigatti, Francesco Bianchi