Abstract: Disclosed is a preamplifier which is responsive to a physiological potential developed by a subject and operative to develop a potential suitably isolated therefrom, the preamplifier including a pair of input networks for receiving therebetween the physiological potential, a pair of operational amplifiers each connected in a unity (voltage) gain, voltage follower, configuration and each driven by a respective one of the input networks, a low resistance resistor connected between the voltage followers to directly develop from the potential a current of suitable level for directly driving an optical isolator, and an optical isolator having an input portion which is connected in the feedback path of one of the operational amplifiers so as to be driven by the current and an output portion at which the optical isolator develops the isolated potential.