Patents Assigned to Siemens Healthcare Diagnostic Inc
  • METHODS AND APPARATUS FOR HILN CHARACTERIZATION USING CONVOLUTIONAL NEURAL NETWORK
    Publication number: 20200151498
    Abstract: A method of characterizing a serum and plasma portion of a specimen in regions occluded by one or more labels. The characterization may be used for determining Hemolysis (H), Icterus (I), and/or Lipemia (L), or Normal (N) of a serum or plasma portion of a specimen. The method includes capturing one or more images of a labeled specimen container including a serum or plasma portion, processing the one or more images with a convolutional neural network to provide a determination of Hemolysis (H), Icterus (I), and/or Lipemia (L), or Normal (N). In further embodiments, the convolutional neural network can provide N-Class segmentation information. Quality check modules and testing apparatus adapted to carry out the method are described, as are other aspects.
    Type: Application
    Filed: April 10, 2018
    Publication date: May 14, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Shanhui SUN, Stefan KLUCKNER, Yao-Jen CHANG, Terrence CHEN, Benjamin S. POLLACK
  • SCAVENGER PROTEIN(S) FOR IMPROVED PRESERVATION OF ANALYTE DETECTION SENSOR(S) AND METHOD(S) OF USE THEREOF
    Publication number: 20200140917
    Abstract: Composition(s), device(s), kit(s), and method(s) for an improved analyte detection sensor(s) comprising at least one scavenger protein and method(s) of preserving the functioning and functional life of the improved analyte detection sensor(s).
    Type: Application
    Filed: July 30, 2018
    Publication date: May 7, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Janine Cox, Christopher Lawrence, Murli Narayan, David Ledden
  • Intelligent service assistant inference engine
    Patent number: 10643747
    Abstract: A method of providing dynamic analysis for troubleshooting in vitro diagnostics instrument issues includes receiving, at a second computing device in communication with a plurality of instruments, identification of an issue associated with a portion of an instrument of the plurality of instruments, the identification received from a first computing device in communication with the instrument. A central computing device accesses data from one or more databases and determines an ordering of one or more corrective actions for resolving the issue by applying the data to a probabilistic model based on at least one of: patterns from the plurality of instruments; and operator input. The central computing device provides the one or more corrective actions in the determined order to the first computing device to be displayed via a user interface at the instrument.
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: May 5, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Arnold Rudorfer, Steve Magowan, Markus Schmitt
  • MODULAR WASH BRIDGE FOR MULTIPLE-PASS IMMUNOASSAY SYSTEMS
    Publication number: 20200132707
    Abstract: A wash system for use in an in vitro diagnostic immunoanalyzer utilizes a bridge having a linear track to move cuvettes from one incubation ring portion to another incubation ring portion. Washing stations along the linear track provide a magnetic field and fluid washing of cuvette contents independent of the size and motion of one or more incubation rings.
    Type: Application
    Filed: June 22, 2018
    Publication date: April 30, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Ayman Ismail, Eric Gerolstein, Brian Bolger
  • Reagent container anti-evaporation tube
    Patent number: 10627417
    Abstract: An anti-evaporation tube for use with an in vitro diagnostics automation system is provided. The anti-evaporation tube includes an anti-evaporation tube body configured to be automatically inserted in a container and to limit evaporation of one or more fluids in the container and an alignment portion disposed on the anti-evaporation tube body. The alignment portion is configured to automatically align the anti-evaporation tube body within the container and cause the anti-evaporation tube body to remain aligned within the container. The alignment portion includes one or more openings disposed on an upper area of the anti-evaporation tube body. The one or more openings are configured to provide ventilation.
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: April 21, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Joseph Brennan, James Kegelman, William Hudson
  • RETENTION CLIP AND SAMPLE RACK FOR A SAMPLE ANALYSIS SYSTEM
    Publication number: 20200114364
    Abstract: An embodiment is a sample rack system. The sample rack system comprises a rack having a base, a top opposite the base along a vertical direction, a receptacle that extends from the top toward the base along the vertical direction, and a receiver element proximate the top. The receptacle is sized to receive a sample collection unit. The system also includes a retention clip for holding the sample collection unit in the receptacle. The retention clip includes an engagement head for attachment to the receiver element of the rack. The engagement head defines an outer surface. The retention clip also includes a curved tail that extends from the engagement head and contacts the sample collection unit when the sample collection unit is placed in the receptacle. The outer surface of the retention clip does not project outwardly from the rack when the retention clip is attached to the rack.
    Type: Application
    Filed: May 8, 2018
    Publication date: April 16, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Andrew Dunbar, Michael Chen, William Perry, Steven Geehan, Gyula Hojer, Norbert Laszka
  • Virtual staining of cells in digital holographic microscopy images using general adversarial networks
    Patent number: 10614287
    Abstract: A cell visualization system includes a digital holographic microscopy (DHM) device, a training device, and a virtual staining device. The DHM device produces DHM images of cells and the virtual staining device colorizes the DHM images based on an algorithm generated by the training device using generative adversarial networks and unpaired training data. A computer-implemented method for producing a virtually stained DHM image includes acquiring an image conversion algorithm which was trained using the generative adversarial networks, receiving a DHM image with depictions of one or more cells and virtually staining the DHM image by processing the DHM image using the image conversion algorithm. The virtually stained DHM image includes digital colorization of the one or more cells to imitate the appearance of a corresponding actually stained cell.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: April 7, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Noha Youssry El-Zehiry, Saikiran Rapaka, Ali Kamen
  • Reaction vessel handling apparatus, testing apparatus, and methods using same
    Patent number: 10613106
    Abstract: Disclosed is a reaction vessel handling apparatus adapted for use in a biological fluid testing apparatus. The reaction vessel handling apparatus includes an incubation member and wash member that are overlapping. A transfer device transfers reaction vessels between the incubation member and wash member at the overlapping portions. Incubation and wash members may be rings. Testing apparatus (e.g., immunoassay apparatus or clinical analyzer apparatus) including the reaction vessel handling apparatus and methods of operating the apparatus are provided, as are other aspects.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: April 7, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Beri Cohen, Nicolae Dumitrescu
  • Magnesium sensing membrane for potentiometric ion selective electrode for measuring ionized magnesium and methods of production and use thereof
    Patent number: 10605762
    Abstract: A magnesium sensing membrane is disclosed for use in a potentiometric ion selective electrode that exhibits improved stability upon exposure to surfactant-containing reagents. Kits containing same are disclosed, along with methods of production and use of the magnesium sensing membrane.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: March 31, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Wei Zhang, Kevin Horan
  • SENSOR ASSEMBLY HAVING MICROSENSORS
    Publication number: 20200096469
    Abstract: A system includes a sample analyzer having a sensor assembly. The sensor assembly includes a first microsensor having a first outer sheath, a first membrane core within the first outer sheath, and a first conductive element at least partially encased by and in contact with the first membrane core. The first conductive element detects a first electrical response signal when the first membrane core is in contact with the fluid. The sensor assembly may include a second microsensor that is adjacent to the first microsensor. The second microsensor has a second outer sheath, a second membrane core within the outer sheath, and a second conductive element at least partially encased by and in direct contact with the second membrane core. The second conductive element detects the second electrical response signal when the second membrane core is in contact with the fluid.
    Type: Application
    Filed: December 13, 2017
    Publication date: March 26, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Jennifer Samproni
  • SIMULTANEOUS MEASUREMENT OF MULTIPLE ANALYTES OF A LIQUID ASSAY
    Publication number: 20200080994
    Abstract: Analyzers and methods for making and using analyzers are described such as a method in which multiple absorption readings of a liquid assay are obtained by a photodetector using multiple light sources having at least three separate and independent wavelength ranges and with each of the absorption readings taken at a separate instant of time. Using at least one processor and calibration information of the liquid assay, an amount of at least two analytes within the liquid assay using the multiple absorption readings is determined.
    Type: Application
    Filed: December 12, 2017
    Publication date: March 12, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Jacques Brunelle
  • DEVICES AND METHODS FOR MINIMIZING FALSE RESULTS FOR TEST SAMPLE REAGENTS ON INSTRUMENT-BASED SYSTEMS
    Publication number: 20200072755
    Abstract: Methods of detecting compromise of at least one analyte reagent upon reaction with a test sample are disclosed. Also disclosed are reflectance spectroscopic diagnostic instruments that perform the method, and systems that contain same.
    Type: Application
    Filed: December 12, 2017
    Publication date: March 5, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Lloyd Schulman, Christopher Zimmerle, Julie Chaney
  • SAMPLE RECEIVING ASSEMBLY AND PROBE
    Publication number: 20200072861
    Abstract: A sample receiving assembly capable of receiving a fluid sample from sample containers having different sizes and shapes includes an arm, an arm holder, a sample probe, and a support member, the support member having a bore therethrough and a plurality of linear grooves. The arm is disposed within the arm holder and the sample probe is disposed within the arm. The arm holder includes a hollow pivot pin insertable through the bore in the support member. The sample probe has a first portion extendable through a distal end of the arm, and a second portion extending axially through the hollow pivot pin. The plurality of linear grooves in the support member are sized and positioned to receive a guide pin on the arm and guide retraction of the arm into the arm holder from an extended position to a retracted position.
    Type: Application
    Filed: December 12, 2017
    Publication date: March 5, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Kenneth P. Galano
  • Method and device for prevention of splashing of non-capped fluid sample during transport on diagnostic laboratory Equipment
    Patent number: 10576473
    Abstract: An assembly for mitigating spillage of patient sample in a patient sample tube having an open top includes a patient sample in the tube and a layer of inert material floating on the sample fluid, such that the material restricts splashing movement of the sample's surface. The material can include a foam, a gel, or a disk. The disk can be approximately the diameter of the sample tube with a center opening configured to accept a pipette to provide access to the patient sample.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: March 3, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Keld Sorensen, Baris Yagci, Robert Hempton
  • DEVICES AND METHODS FOR MINIMIZING HOOK EFFECT INTEFERENCE IN IMMUNOASSAYS
    Publication number: 20200064339
    Abstract: Methods of minimizing hook effect interference in an immunoassay are disclosed. Also disclosed are reagents, kits, and immunoassay devices that may be utilized in accordance with the method.
    Type: Application
    Filed: May 4, 2018
    Publication date: February 27, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Chris Zimmerle, Gary Rheinheimer
  • BIOSENSORS PRODUCED FROM ENZYMES WITH REDUCED SOLUBILITY AND METHODS OF PRODUCTION AND USE THEREOF
    Publication number: 20200064296
    Abstract: Multi-use biosensors are disclosed that include enzymes that have been modified to reduce the solubility thereof; the multi-use biosensors are used to detect analytes in fluidic biological samples, and the biosensors also maintain their enzyme activity after many uses. Multi-sensor arrays are disclosed that include multiple biosensors. Also disclosed are methods of producing and using these devices.
    Type: Application
    Filed: May 3, 2018
    Publication date: February 27, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Michael S. WILSON
  • SAMPLE RACK FOR SAMPLE ANALYSIS SYSTEM
    Publication number: 20200064362
    Abstract: An embodiment of the disclosure is a rack adapted to engage a rack handler. The rack includes a rack body. The rack body has a bottom, a top opposite the bottom, and a receptacle that extends from the top toward the bottom. The receptacle is sized to receive the sample collection unit. The rack body has a first interior surface that extends from the bottom toward the top, and a second interior surface that extends from the bottom toward the top. The second interior surface is opposite to the first interior surface so as to at least partially define a slot along the bottom. The rack body also includes an interference groove in the slot along at least one of the first interior surface and the second interior surface. The slot and the interference groove are sized to engage a portion of the rack handler.
    Type: Application
    Filed: May 8, 2018
    Publication date: February 27, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: William Perry, Michael Chen, Steven Geehan, Gyula Hojer, Norbert Laszka
  • SAMPLE RACK HANDLER AND ROTATION ASSEMBLY FOR A SAMPLE ANALYSIS SYSTEM
    Publication number: 20200064363
    Abstract: An embodiment is a sample analysis system for analyzing a sample that includes at least one test device for analyzing the sample. The system also includes a rack handler operable to move a sample from a first location to a second location along a travel path. The rack handler has a rotation assembly including a) an engagement element for engagement with the sample rack, and b) a motor coupled to the engagement element and is operable to cause rotation of the engagement element. The rotation assembly rotates the sample rack from a first orientation into a second orientation along the travel path when the engagement element engages the sample rack.
    Type: Application
    Filed: May 8, 2018
    Publication date: February 27, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: William Perry, Michael Chen, Steven Geehan, Gyula Hojer, Norbert Laszka
  • INTERNAL ELECTROLYTE LAYER COMPRISING CARBON PASTE FOR POTENTIOMETRIC ION SELECTIVE ELECTRODE
    Publication number: 20200057017
    Abstract: Disclosed are internal electrolyte layers for ion selective electrodes, wherein the internal electrolyte layers contain carbon paste doped with a metal salt. Also disclosed are ion selective electrodes and sensor array assemblies containing the internal electrolyte layers. Also disclosed are methods of producing and using the internal electrolyte layers, ion selective electrodes, and sensor array assemblies.
    Type: Application
    Filed: May 8, 2018
    Publication date: February 20, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Wei Zhang, Robert Bergquist, Amir Dolaty, Todd Andrade, Amanda Whittaker
  • Prefixation for increased rare cell recovery
    Patent number: 10564075
    Abstract: Traditionally, enriching or isolating rare circulating cells from a sample has proven difficult as rare circulating cells can be heterogeneous, which limits the use of techniques based on biological properties (e.g., cell surface markers), and can be flexible, which hinders techniques based on physical properties (e.g., diameter size). Methods disclosed herein are capable of enriching or isolating rare circulating cells are minimally impacted by heterogeneity or flexibility of rare circulating cells, and therefore, overcome disadvantages observed with prior techniques. For example, a method for enriching or isolating rare circulating cells from a sample of a subject including fixing one or more rare circulating cells in a sample to create a fixed sample, and isolating the one or more rare circulating cell from the fixed sample using a size exclusion technique is disclosed.
    Type: Grant
    Filed: February 23, 2016
    Date of Patent: February 18, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Xiaolei Qiu, Sunil Pandit