Abstract: A control system for a fluid analyzer is described. The control system has a processor executing processor executable code to: control a potentiostat to apply a first voltage potential sufficient to induce a first electrochemical reaction of a target analyte or a reaction byproduct of the target analyte in a sample of the calibration reagent and receive a first reading from the potentiostat; control the potentiostat to apply a second voltage potential insufficient to induce a second electrochemical reaction of the target analyte or a reaction byproduct of the target analyte in the sample of the calibration reagent and receive a second reading from the potentiostat; calculate calibration parameters using the first reading, the second reading and a multi-point calibration algorithm; and measure a target analyte concentration within the fluid sample using the calibration parameters.

Abstract: There is provided a chloride selective membrane including an epoxide-based matrix reacted with a stoichiometric amount of an amino compound and an activator such that the epoxide-based matrix comprising a number of quaternary ammonium groups.

Abstract: Particles are released from a particle-containing area of a first surface of a porous matrix. The particle-containing area is contacted with a liquid medium and sonic energy is applied to an opposing area on a second surface of the porous matrix, wherein the opposing area is opposite to the particle-containing area. The particles may be biological particles or non-biological particles.

Abstract: In one embodiment, a biological sample analyzer has a housing having at least one outer wall that defines a cavity therein. A receptacle, which can support a consumable holder containing a biological sample, is disposed within the internal cavity. At least one heater applies heat to the receptacle when the consumable holder is supported by the receptacle. At least one heater sensor detect temperatures of the receptacle over time. A controller detects whether the consumable holder is below an ambient temperature based on a decrease in temperature of the receptacle when the consumable holder is inserted into the receptacle. The controller also increases an amount of thermal energy transferred from the at least one heater to the consumable holder when the controller detects that the consumable holder is below the ambient temperature so as to heat the consumable holder to a target temperature.

Abstract: A computer-implemented method and a data processing apparatus provide and apply a trained probabilistic graphical model for verifying and/or improving the consistency of labels within the scope of medical image processing. Also provided are a computer-implemented method for verifying and/or improving the consistency of labels within the scope of medical imaging processing, a data processing apparatus embodied to verify and/or improve the consistency of labels within the scope of medical image processing, and a corresponding computer program product and a computer-readable medium.

Abstract: A method and system is described that includes obtaining a whole blood sample and obtaining a first light absorbance profile of the whole blood sample. Next, the whole blood sample is hemolyzed to generate a hemolyzed sample of blood and a second light absorbance profile of the hemolyzed sample of blood is obtained. The level of hemolysis in the whole blood sample is determined by comparing the first light absorbance profile and the second light absorbance profile.

Abstract: Kits containing a multiplexed chemiluminescent detection system and microfluidics devices and methods for detecting the presence and/or concentration of biotin and at least one target analyte in a sample are disclosed. The kits, microfluidics devices, and methods utilize singlet oxygen-activatable chemiluminescent compounds in combination with two or more fluorescent molecules that emit light at different wavelengths.

Abstract: A method of spectroscopically measuring percent glycated hemoglobin or a glycated hemoglobin:total hemoglobin ratio in a biological sample is disclosed. The method includes the use of a turbidity normalization algorithm to normalize the total hemoglobin concentration calculated from the spectroscopic measurements to substantially remove any turbidity interference therefrom. The turbidity normalization eliminates the negative bias observed with intralipid/lipemia and thus provides a glycated hemoglobin assay with no significant interference from intralipid/lipemia.

Abstract: An acoustic analyzer system is provided that includes an acoustic analyzer having a reusable glass flow cell positioned within the acoustic analyzer. A disposable card body may be inserted into the acoustic analyzer and deliver sample fluid to the glass flow cell so that acoustic-wave assisted measurements may be performed on the sample fluid. The disposable card body may also deliver wash fluid to the glass flow cell, and receive waste sample fluid and waste wash fluid from the glass flow cell to prepare the glass flow cell for subsequent sample fluids. Numerous other embodiments are provided.

Abstract: Embodiments are directed to a carrier configured to hold and transport a vessel with a barcode label in an automation system in in vitro diagnostics (IVD) environment, with a plurality of peripheral readers able to read the barcode label. The reading of the barcode label on the vessel loaded into the carrier is achieved without the need to align (either manually or automatically) the barcode to the peripheral readers. A dual spring arrangement provides for consistent vessel capture when loading the vessel into the carrier and for retention in the carrier during transport operations. A centrally-located spring housing provides efficient space utilization. A mirrored dual slot design is provided so that an unobstructed space for each slot is complimentary such that a completely unobstructed view of the vessel is constructed by imaging the same vessel in both slots (one after another) and fusing the resulting data.

Abstract: The present invention provides compounds used in the synthesis of chemiluminescent acridinium compounds and methods of producing these compounds. Specifically, methods are provided for the N-alkylation of acridan compounds using alkylating reagents. Typically, these alkylating reagents comprise a protected sulfonate group protected with an acid-labile protecting group.

Abstract: Methods of detecting compromise of at least one analyte reagent upon reaction with a test sample are disclosed. Also disclosed are reflectance spectroscopic diagnostic instruments that perform the method, and systems that contain same.

Abstract: A system that include an sample analyzer having a sensor array. The sensor array includes a housing having a base, a top spaced above the base, and an outer wall that extends from the base to the top. The sensor array includes an inlet that is sized to receive a sample of the fluid, and a plurality of partitions arranged around the fluid inlet. Each partition has a port at the fluid inlet for receiving a portion of the sample of fluid received by the fluid inlet. The sensor array includes at least one sensor in each partition. The sensor array is configured to selectively direct the sample of fluid received by the fluid inlet into one or more of the plurality of partitions into contact the at least one sensor.

Abstract: Disclosed herein are methods of detecting ascorbic acid in a urine sample from a subject, including contacting at least a portion of the urine sample with a test strip including a reagent pad and detecting whether ascorbic acid is present in the urine sample by measuring an intensity of color on the reagent pad, wherein a reduction in the intensity of color on the reagent pad indicates the presence of ascorbic acid.

Abstract: An illumination unit is described that includes a first light source positioned on a first axis and a second light source on a second axis that intersects and is angularly offset with respect to the first axis. The illumination unit includes a reflector having an aperture through which the first axis extends and a reflective surface angled with respect to the first axis and second axis.

Abstract: Disclosed is a syringe apparatus. Syringe apparatus has a barrel including an inner surface, an open end, and an inlet end; a plunger including a plunger head received in slidable sealing contact with the inner surface of the barrel and forming a reservoir therein; and an extensible member, optionally including an additive, is contained in the reservoir. Extensible member can be coupled between the inlet end and the plunger head and is extensible in length L as a bio-liquid (e.g., whole blood) is drawn into the reservoir. Methods of mixing or adding an additive such as an anticoagulant, coagulant, or marker, to a bio-liquid are provided, as are other aspects.

Abstract: In vitro diagnostic sensors are disclosed that include membranes formed of a polymer matrix that has been modified to contain surface adhesion functional group(s) that enables attachment of the membrane to a substrate of the sensor. Also disclosed are membranes of these sensors as well as multi-sensor arrays that include multiple sensors. In addition, methods of producing and using these membranes, sensors, and arrays are disclosed.

Abstract: Antibodies that specifically bind naloxone or naltrexone are disclosed. Also disclosed are conjugates used in the production of the antibodies, as well as methods of producing the antibodies. Also disclosed are methods of using the antibodies in direct assays for naloxone or naltrexone. Further disclosed are methods of reducing naloxone or naltrexone interference in opiate assays using the antibodies.

Abstract: In point of care system is provided that includes an instrument data manager (IDM) configured to communicate with a diagnostic engine and to (1) obtain identification (ID) information of a patient for which a test is to be performed; (2) obtain ID information of a diagnostic consumable to be used to collect a sample from the patient; (3) link the obtained patient ID information with the obtained diagnostic consumable ID information; and (4) restrict testing using the diagnostic engine by (a) prior to performing a test on a sample collected with a diagnostic consumable, determine ID information of the diagnostic consumable at the diagnostic engine; (b) determine whether the diagnostic consumable is linked with patient information within the IDM; and (c) if so, allow the diagnostic engine to perform a test on the sample collected with the diagnostic consumable. Numerous other embodiments are provided.