Patents Assigned to SIFI S.P.A.
  • Patent number: 9161906
    Abstract: The present invention refers to pharmaceutical formulations based on lipids for ophthalmic use comprising a phospholipid component composed of zwitterionic phospholipids of natural origin and an oily component composed of oils of natural origin emulsified in water. In particular, the invention refers to ophthalmic formulations useful, for example, for transporting drugs to the eye and in the treatment of ocular dryness, capable of restoring the lipid layer of the tear film. In particular, in a non-transitory but pathological situation such as the dry eye syndrome, such formulations also succeed in reducing the often-present inflammatory component.
    Type: Grant
    Filed: December 24, 2007
    Date of Patent: October 20, 2015
    Assignee: SIFI, S.P.A.
    Inventors: Maria Grazia Mazzone, Valeria Maria Carmela Moschetti, Fausto Giuseppe Miano, Letizia Gaetana Lo Grasso
  • Patent number: 8912164
    Abstract: The present invention relates to a pharmaceutical formulation comprising xanthan gum as a re-epithelializing active principle optionally mixed with hyaluronic acid. The composition speeds up and improves advantageously the formation of newly grown epithelium.
    Type: Grant
    Filed: April 24, 2003
    Date of Patent: December 16, 2014
    Assignee: SIFI S.p.A.
    Inventors: Maria Grazia Mazzone, Grazia Paladino, Clara Marino, Ornella Peri, Vincenzo Enea
  • Publication number: 20100291226
    Abstract: The present invention refers to pharmaceutical formulations based on lipids for ophthalmic use comprising a phospholipid component composed of zwitterionic phospholipids of natural origin and an oily component composed of oils of natural origin emulsified in water. In particular, the invention refers to ophthalmic formulations useful, for example, for transporting drugs to the eye and in the treatment of ocular dryness, capable of restoring the lipid layer of the tear film. In particular, in a non-transitory but pathological situation such as the dry eye syndrome, such formulations also succeed in reducing the often-present inflammatory component.
    Type: Application
    Filed: December 24, 2007
    Publication date: November 18, 2010
    Applicant: SIFI S.P.A.
    Inventors: Maria Mazzone, Valeria Maria Carmela Moschetti, Fausto Giuseppe Miano, Letizia Gaetana Lo Grasso
  • Publication number: 20090221545
    Abstract: The present invention relates in general to the use of amphiphilic graft-type copolymers of polyaspartamide for the ophthalmic administration of drugs, such as for example steroidal and non-steroidal anti-inflammatory agents, antimicrobial agents such as aminoglycosides, macrolides, cephalosporin, tetracycline, quinolones, penicillin, beta-lactams, anti-glaucoma agents such as prostaglandins, alpha- and beta-blockers, inhibitors of carbonic anhydrase, cannabinoids, antiviral agents, diagnostic agents, anti-angiogenic agents, antioxidants.
    Type: Application
    Filed: March 15, 2007
    Publication date: September 3, 2009
    Applicant: SIFI S.P.A.
    Inventors: Gaetano Giammona, Gennara Cavallaro, Mariano Licciardi, Claudine Civiale, Grazia Maria Paladino, Maria Grazia Mazzone
  • Publication number: 20080146530
    Abstract: The present invention relates to the use of xanthan gum as re-epithelializing agent and, in particular, to a pharmaceutical formulation comprising xanthan gum as a re-epithelializing active principle eventually mixed with hyaluronic acid. Said use and composition speed up and improve advantageously the formation of newly grown epithelium.
    Type: Application
    Filed: February 14, 2008
    Publication date: June 19, 2008
    Applicant: SIFI S.p.A.
    Inventors: Maria Grazia MAZZONE, Grazia Paladino, Clara Marino, Ornella Peri, Vincenzo Enea
  • Publication number: 20080139502
    Abstract: The present invention relates to the use of xanthan gum as re-epithelializing agent and, in particular, to a pharmaceutical formulation comprising xanthan gum as a re-epithelializing active principle eventually mixed with hyaluronic acid. Said use and composition speed up and improve advantageously the formation of newly grown epithelium.
    Type: Application
    Filed: February 14, 2008
    Publication date: June 12, 2008
    Applicant: SIFI S.p.A.
    Inventors: Maria Grazia Mazzone, Grazia Paladino, Clara Marino, Ornella Peri, Vincenzo Enea
  • Publication number: 20080139522
    Abstract: The present invention relates to the use of xanthan gum as re-epithelializing agent and, in particular, to a pharmaceutical formulation comprising xanthan gum as a re-epithelializing active principle eventually mixed with hyaluronic acid. Said use and composition speed up and improve advantageously the formation of newly grown epithelium.
    Type: Application
    Filed: February 14, 2008
    Publication date: June 12, 2008
    Applicant: SIFI S.p.A..
    Inventors: Maria Grazia Mazzone, Grazia Paladino, Clara Marino, Ornella Peri, Vincenzo Enea
  • Publication number: 20030109422
    Abstract: The present invention relates to a process for the preparation of pharmaceutical formulations containing the glycoprotein lactoferrin and/or its peptide fragments in therapeutical quantities, in which said process is performed at a temperature between 0 and 25° C.
    Type: Application
    Filed: August 14, 2002
    Publication date: June 12, 2003
    Applicant: SIFI S.p.A.
    Inventors: Maria Grazia Mazzone, Manuela Marrano, Antonino Asero, Grazia Paladino, Clara Marino, Anna Rita Blanco, Carla Amico, Vincenzo Enea