Patents Assigned to SIFI S.P.A.
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Patent number: 11672760Abstract: Provided are oil-in-water microemulsions for formulating pharmaceutically active compounds. The microemulsions contain oils, surfactants, water, and the pharmaceutical compounds, and are produced by mixing an aqueous phase and a lipid phase in which each phase contains at least one surfactant in a defined ratio whereby the resulting microemulsion has very small dispersed particles and is thermodynamically very stable.Type: GrantFiled: March 19, 2021Date of Patent: June 13, 2023Assignees: SIFI S.p.A., Consiglio Nazionale delle RicercheInventors: Elena Solfato, Ilenia Abbate, Cristina Maria Concetta Zappulla, Manuela Santonocito, Santa Viola, Sandro De Falco, Francesco Giuliano
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Patent number: 10980745Abstract: Provided are oil-in-water microemulsions for formulating pharmaceutically active compounds. The microemulsions contain oils, surfactants, water, and the pharmaceutical compounds, and are produced by mixing an aqueous phase and a lipid phase in which each phase contains at least one surfactant in a defined ratio whereby the resulting microemulsion has very small dispersed particles, and, is thermodynamically very stable.Type: GrantFiled: October 1, 2019Date of Patent: April 20, 2021Assignees: SIFI S.p.A., Consiglio Nazionale delle RicercheInventors: Elena Solfato, Ilenia Abbate, Cristina Maria Concetta Zappulla, Manuela Santonocito, Santa Viola, Sandro De Falco, Francesco Giuliano
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Patent number: 9161906Abstract: The present invention refers to pharmaceutical formulations based on lipids for ophthalmic use comprising a phospholipid component composed of zwitterionic phospholipids of natural origin and an oily component composed of oils of natural origin emulsified in water. In particular, the invention refers to ophthalmic formulations useful, for example, for transporting drugs to the eye and in the treatment of ocular dryness, capable of restoring the lipid layer of the tear film. In particular, in a non-transitory but pathological situation such as the dry eye syndrome, such formulations also succeed in reducing the often-present inflammatory component.Type: GrantFiled: December 24, 2007Date of Patent: October 20, 2015Assignee: SIFI, S.P.A.Inventors: Maria Grazia Mazzone, Valeria Maria Carmela Moschetti, Fausto Giuseppe Miano, Letizia Gaetana Lo Grasso
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Patent number: 8912164Abstract: The present invention relates to a pharmaceutical formulation comprising xanthan gum as a re-epithelializing active principle optionally mixed with hyaluronic acid. The composition speeds up and improves advantageously the formation of newly grown epithelium.Type: GrantFiled: April 24, 2003Date of Patent: December 16, 2014Assignee: SIFI S.p.A.Inventors: Maria Grazia Mazzone, Grazia Paladino, Clara Marino, Ornella Peri, Vincenzo Enea
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Publication number: 20100291226Abstract: The present invention refers to pharmaceutical formulations based on lipids for ophthalmic use comprising a phospholipid component composed of zwitterionic phospholipids of natural origin and an oily component composed of oils of natural origin emulsified in water. In particular, the invention refers to ophthalmic formulations useful, for example, for transporting drugs to the eye and in the treatment of ocular dryness, capable of restoring the lipid layer of the tear film. In particular, in a non-transitory but pathological situation such as the dry eye syndrome, such formulations also succeed in reducing the often-present inflammatory component.Type: ApplicationFiled: December 24, 2007Publication date: November 18, 2010Applicant: SIFI S.P.A.Inventors: Maria Mazzone, Valeria Maria Carmela Moschetti, Fausto Giuseppe Miano, Letizia Gaetana Lo Grasso
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Publication number: 20090221545Abstract: The present invention relates in general to the use of amphiphilic graft-type copolymers of polyaspartamide for the ophthalmic administration of drugs, such as for example steroidal and non-steroidal anti-inflammatory agents, antimicrobial agents such as aminoglycosides, macrolides, cephalosporin, tetracycline, quinolones, penicillin, beta-lactams, anti-glaucoma agents such as prostaglandins, alpha- and beta-blockers, inhibitors of carbonic anhydrase, cannabinoids, antiviral agents, diagnostic agents, anti-angiogenic agents, antioxidants.Type: ApplicationFiled: March 15, 2007Publication date: September 3, 2009Applicant: SIFI S.P.A.Inventors: Gaetano Giammona, Gennara Cavallaro, Mariano Licciardi, Claudine Civiale, Grazia Maria Paladino, Maria Grazia Mazzone
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Publication number: 20080146530Abstract: The present invention relates to the use of xanthan gum as re-epithelializing agent and, in particular, to a pharmaceutical formulation comprising xanthan gum as a re-epithelializing active principle eventually mixed with hyaluronic acid. Said use and composition speed up and improve advantageously the formation of newly grown epithelium.Type: ApplicationFiled: February 14, 2008Publication date: June 19, 2008Applicant: SIFI S.p.A.Inventors: Maria Grazia MAZZONE, Grazia Paladino, Clara Marino, Ornella Peri, Vincenzo Enea
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Publication number: 20080139502Abstract: The present invention relates to the use of xanthan gum as re-epithelializing agent and, in particular, to a pharmaceutical formulation comprising xanthan gum as a re-epithelializing active principle eventually mixed with hyaluronic acid. Said use and composition speed up and improve advantageously the formation of newly grown epithelium.Type: ApplicationFiled: February 14, 2008Publication date: June 12, 2008Applicant: SIFI S.p.A.Inventors: Maria Grazia Mazzone, Grazia Paladino, Clara Marino, Ornella Peri, Vincenzo Enea
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Publication number: 20080139522Abstract: The present invention relates to the use of xanthan gum as re-epithelializing agent and, in particular, to a pharmaceutical formulation comprising xanthan gum as a re-epithelializing active principle eventually mixed with hyaluronic acid. Said use and composition speed up and improve advantageously the formation of newly grown epithelium.Type: ApplicationFiled: February 14, 2008Publication date: June 12, 2008Applicant: SIFI S.p.A..Inventors: Maria Grazia Mazzone, Grazia Paladino, Clara Marino, Ornella Peri, Vincenzo Enea
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Publication number: 20030109422Abstract: The present invention relates to a process for the preparation of pharmaceutical formulations containing the glycoprotein lactoferrin and/or its peptide fragments in therapeutical quantities, in which said process is performed at a temperature between 0 and 25° C.Type: ApplicationFiled: August 14, 2002Publication date: June 12, 2003Applicant: SIFI S.p.A.Inventors: Maria Grazia Mazzone, Manuela Marrano, Antonino Asero, Grazia Paladino, Clara Marino, Anna Rita Blanco, Carla Amico, Vincenzo Enea