Abstract: Polymorph forms of 4-trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl)-benzamide are disclosed as well as their methods of synthesis and pharmaceutical compositions.
Type:
Grant
Filed:
December 29, 2020
Date of Patent:
February 6, 2024
Assignee:
Siga Technologies, Inc.
Inventors:
Shanthakumar R. Tyavanagimatt, Melialani A. C. L. S. Anderson, William C. Weimers, Dylan Nelson, Tove' C. Bolken, Dennis E. Hruby, Michael H. O'Neill, Gary Sweetapple, Kelley A. McCloughan
Abstract: The present invention is directed to a dry suspension for reconstitution containing Tecovirimat (ST-246) powder and simethicone. The dry suspension is dispersed in water to provide an aqueous pharmaceutical suspension formulation for oral administration for treating orthopoxvirus infections and/or eczema vaccinatum. The suspension formulation exhibits excellent stability and good dissolution and has an improved taste and texture.
Type:
Grant
Filed:
July 14, 2022
Date of Patent:
October 10, 2023
Assignee:
Siga Technologies, Inc.
Inventors:
Shanthakumar R. Tyavanagimatt, Kris Holt, Ying Tan, Melialani A. C. L. S. Anderson, Dennis E. Hruby
Abstract: The present invention is directed to a dry suspension for reconstitution containing Tecovirimat (ST-246) powder and simethicone. The dry suspension is dispersed in water to provide an aqueous pharmaceutical suspension formulation for oral administration for treating orthopoxvirus infections and/or eczema vaccinatum. The suspension formulation exhibits excellent stability and good dissolution and has an improved taste and texture.
Type:
Application
Filed:
July 14, 2022
Publication date:
January 19, 2023
Applicant:
SIGA TECHNOLOGIES, INC.
Inventors:
Shanthakumar R. TYAVANAGIMATT, Kris HOLT, Ying TAN, Melialani A.C.L.S. ANDERSON, Dennis E. HRUBY
Abstract: The present invention is directed to a dry suspension for reconstitution containing Tecovirimat (ST-246) powder and simethicone. The dry suspension is dispersed in water to provide an aqueous pharmaceutical suspension formulation for oral administration for treating orthopoxvirus infections and/or eczema vaccinatum. The suspension formulation exhibits excellent stability and good dissolution and has an improved taste and texture.
Type:
Grant
Filed:
February 15, 2017
Date of Patent:
September 6, 2022
Assignee:
Siga Technologies, Inc.
Inventors:
Shanthakumar R. Tyavanagimatt, Kris Holt, Ying Tan, Melialani A. C. L. S. Anderson, Dennis E. Hruby
Abstract: The present invention is directed to a dry suspension for reconstitution containing Tecovirimat (ST-246) powder and simethicone. The dry suspension is dispersed in water to provide an aqueous pharmaceutical suspension formulation for oral administration for treating orthopoxvirus infections and/or eczema vaccinatum. The suspension formulation exhibits excellent stability and good dissolution and has an improved taste and texture.
Type:
Application
Filed:
February 15, 2017
Publication date:
July 15, 2021
Applicant:
SIGA TECHNOLOGIES, INC.
Inventors:
Shanthakumar R. TYAVANAGIMATT, Kris HOLT, Ying TAN, Melialani A.C.L.S. ANDERSON, Dennis E. HRUBY
Abstract: Polymorph forms of 4-trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl)-benzamide are disclosed as well as their methods of synthesis and pharmaceutical compositions.
Type:
Application
Filed:
December 29, 2020
Publication date:
May 13, 2021
Applicant:
Siga Technologies, Inc.
Inventors:
Shanthakumar R. TYAVANAGIMATT, Melialani A.C.L.S. ANDERSON, William C. WEIMERS, Dylan NELSON, Tove' C. BOLKEN, Dennis E. HRUBY, Michael H. O'NEILL, Gary SWEETAPPLE, Kelley A. McCLOUGHAN
Abstract: Polymorph forms of 4-trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl)-benzamide are disclosed as well as their methods of synthesis and pharmaceutical compositions.
Type:
Grant
Filed:
July 24, 2019
Date of Patent:
March 2, 2021
Assignee:
SIGA TECHNOLOGIES INC.
Inventors:
Shanthakumar R. Tyavanagimatt, Melialani A. C. L. S. Anderson, William C. Weimers, Dylan Nelson, Tove′ C. Bolken, Dennis E. Hruby, Michael H. O'Neill, Gary Sweetapple, Kelley A. McCloughan
Abstract: The present invention provides for a novel liquid formulation for solubilizing poorly soluble ST-246 in cyclodextrins and a novel process of making the formulation.
Type:
Grant
Filed:
January 2, 2020
Date of Patent:
December 15, 2020
Assignee:
Siga Technologies Inc.
Inventors:
Shanthakumar R. Tyavanagimatt, Melialani A. C. L. S. Anderson, William Weimers, Gopi Krishna Kasi, N K Peter Samuel, Tove C. Bolken, Dennis E. Hruby
Abstract: Disclosed are methods for hydration of ST-246 particles comprising exposing said particles to moisture by conveying volumes of air containing moisture.
Type:
Grant
Filed:
July 23, 2019
Date of Patent:
July 21, 2020
Assignee:
SIGA TECHNOLOGIES INC.
Inventors:
Shanthakumar R. Tyavanagimatt, Matthew Reeves, N K Peter Samuel, Steven Priebe, Ying Tan, Dennis E. Hruby
Abstract: Disclosed are methods for the preparation of Tecovirimat for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus.
Abstract: The present invention provides for a novel liquid formulation for solubilizing poorly soluble ST-246 in cyclodextrins and a novel process of making the formulation.
Type:
Application
Filed:
January 2, 2020
Publication date:
May 7, 2020
Applicant:
SIGA TECHNOLOGIES, INC.
Inventors:
Shanthakumar R. TYAVANAGIMATT, Melialani A.C.L.S. ANDERSON, William WEIMERS, Gopi Krishna KASI, N K Peter SAMUEL, Tove C. Bolken, Dennis E. HRUBY
Abstract: The present invention provides for a novel liquid formulation for solubilizing poorly soluble ST-246 in cyclodextrins and a novel process of making the formulation.
Type:
Grant
Filed:
October 11, 2018
Date of Patent:
March 3, 2020
Assignee:
Siga Technologies Inc.
Inventors:
Shanthakumar R. Tyavanagimatt, Melialani A. C. L. S. Anderson, William Weimers, Gopi Krishna Kasi, N K Peter Samuel, Tove C. Bolken, Dennis E. Hruby
Abstract: Disclosed are methods for hydration of ST-246 particles comprising exposing said particles to moisture by conveying volumes of air containing moisture.
Type:
Application
Filed:
July 23, 2019
Publication date:
December 19, 2019
Applicant:
SIGA TECHNOLOGIES, INC.
Inventors:
Shanthakumar R. TYAVANAGIMATT, Matthew Reeves, N K Peter SAMUEL, Steven PRIEBE, Ying TAN, Dennis E. HRUBY
Abstract: Polymorph forms of 4-trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl)-benzamide are disclosed as well as their methods of synthesis and pharmaceutical compositions.
Type:
Application
Filed:
July 24, 2019
Publication date:
November 14, 2019
Applicant:
Siga Technologies, Inc.
Inventors:
Shanthakumar R. TYAVANAGIMATT, Melialani A.C.L.S. ANDERSON, William C. WEIMERS, Dylan NELSON, Tove' C. BOLKEN, Dennis E. HRUBY, Michael H. O'NEILL, Gary SWEETAPPLE, Kelley A. McCLOUGHAN
Abstract: Polymorph forms of 4-trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl)-benzamide are disclosed as well as their methods of synthesis and pharmaceutical compositions.
Type:
Grant
Filed:
July 2, 2018
Date of Patent:
September 10, 2019
Assignee:
Siga Technologies Inc.
Inventors:
Shanthakumar R. Tyavanagimatt, Melialani A.C.L.S. Anderson, William C. Weimers, Dylan Nelson, Tove′ C. Bolken, Dennis E. Hruby, Michael H. O'Neill, Gary Sweetapple, Kelley A. McCloughan
Abstract: Disclosed are methods for hydration of ST-246 particles comprising exposing said particles to moisture by conveying volumes of air containing moisture.
Type:
Grant
Filed:
November 14, 2014
Date of Patent:
September 10, 2019
Assignee:
Siga Technologies Inc.
Inventors:
Shanthakumar R. Tyavanagimatt, Matthew Reeves, N K Peter Samuel, Steven Priebe, Ying Tan, Dennis E. Hruby
Abstract: Disclosed are methods for the preparation of Tecovirimat for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus.
Abstract: The present invention provides for a novel liquid formulation for solubilizing poorly soluble ST-246 in cyclodextrins and a novel process of making the formulation.
Type:
Application
Filed:
October 11, 2018
Publication date:
February 7, 2019
Applicant:
SIGA TECHNOLOGIES, INC.
Inventors:
Shanthakumar R. TYAVANAGIMATT, Melialani A.C.L.S. ANDERSON, William WEIMERS, Gopi Krishna KASI, N K Peter SAMUEL, Tove C. Bolken, Dennis E. HRUBY
Abstract: Disclosed are methods for the preparation of Tecovirimat for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus.
Abstract: The present invention provides for a novel liquid formulation for solubilizing poorly soluble ST-246 in cyclodextrins and a novel process of making the formulation.
Type:
Grant
Filed:
January 16, 2018
Date of Patent:
November 13, 2018
Assignee:
SIGA TECHNOLOGIES, INC.
Inventors:
Shanthakumar R. Tyavanagimatt, Melialani A. C. L. S. Anderson, William Weimers, Gopi Krishna Kasi, N K Peter Samuel, Tove C. Bolken, Dennis E. Hruby