Abstract: Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to, Arenaviridae (Junin, Machupo, Guanarito, Sabia, Lassa, Tacaribe, Pichinde, and LCMV), Filoviridae (Ebola and Marburg viruses), Flaviviridae (yellow fever, Omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).
Type:
Application
Filed:
October 26, 2010
Publication date:
July 14, 2011
Applicant:
Siga Technologies Inc.
Inventors:
Dennis E. Hruby, Tove Bolken, Sean M. Amberg, Dongcheng Dai
Abstract: Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to, Arenaviridae (Junin, Machupo, Guanarito, Sabia, Lassa, Tacaribe, Pichinde, and LCMV), Filoviridae (Ebola and Marburg viruses), Flaviviridae (yellow fever, Omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever and Crimean-Congo hemorrhagic fever).
Type:
Grant
Filed:
April 29, 2008
Date of Patent:
July 12, 2011
Assignee:
Siga Technologies, Inc.
Inventors:
Dennis E. Hruby, Tove C. Bolken, Sean Amberg, Dongcheng Dai, Ryan A. Larson
Abstract: Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus.
Type:
Grant
Filed:
April 1, 2010
Date of Patent:
June 7, 2011
Assignee:
Siga Technologies, Inc.
Inventors:
Robert Jordan, Thomas R. Bailey, Susan R. Rippin
Abstract: Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel sulfonyl semicarbazides, carbonyl semicarbazides, semicarbazides, ureas and related compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to, Arenaviridae (Junin, Machupo, Guanarito, Sabia, Lassa, Tacaribe, Pinchinde, and VSV), Filoviridae (ebola and Marburg viruses), Flaviviridae (yellow fever, omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).
Type:
Application
Filed:
October 26, 2010
Publication date:
May 19, 2011
Applicant:
Siga Technologies Inc.
Inventors:
Dongcheng Dai, Tove Bolken, Dennis E. Hruby, Thomas R. Bailey
Abstract: Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to, Arenaviridae (Junin, Machupo, Guanarito, Sabia, Lassa, Tacaribe, Pichinde, and LCMV), Filoviridae (Ebola and Marburg viruses), Flaviviridae (yellow fever, Omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).
Abstract: Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus.
Type:
Application
Filed:
December 21, 2009
Publication date:
January 13, 2011
Applicant:
Siga Technologies Inc.
Inventors:
Robert Jordan, Thomas R. Bailey, Susan R. Rippin
Abstract: Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus.
Type:
Application
Filed:
April 1, 2010
Publication date:
September 9, 2010
Applicant:
Siga Technologies Inc.
Inventors:
Robert Jordan, Thomas R. Bailey, Susan R. Rippin
Abstract: Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases cased by the orthopoxvirus.
Type:
Grant
Filed:
June 18, 2004
Date of Patent:
June 15, 2010
Assignee:
Siga Technologies, Inc.
Inventors:
Robert Jordan, Thomas R. Bailey, Susan R. Rippin
Abstract: Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases cased by the orthopoxvirus.
Type:
Grant
Filed:
April 23, 2007
Date of Patent:
March 30, 2010
Assignee:
Siga Technologies, Inc.
Inventors:
Robert F Jordan, Thomas R. Bailey, Susan R. Rippin, Dongcheng Dai
Abstract: Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel semicarbazides, sulfonyl carbazides, ureas and related compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to Arenaviridae (Junin, Machupo, Guanavito, Sabia and Lassa), Filoviridae (ebola and Marburg viruses), Flaviviridae (yellow fever, omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).
Type:
Application
Filed:
December 6, 2005
Publication date:
August 13, 2009
Applicant:
SIGA TECHNOLOGIES, INC.
Inventors:
Yijun Deng, Theodore J. Nitz, Thomas R. Bailey, Yuanming Zhang, Sylvie Laquerre
Abstract: Described herein are 4-methyl-piperazine-1-carbothioic acid amide derivatives and analogs, as well as compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by hemorrhagic fever viruses, such as Arenaviruses.
Type:
Application
Filed:
January 31, 2007
Publication date:
July 16, 2009
Applicant:
SIGA TECHNOLOGIES, INC.
Inventors:
Dennis E. Hruby, Tove C. Bolken, Dongcheng Dai
Abstract: Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to, Arenaviridae (Junin, Machupo, Guanarito, Sabia, Lassa, Tacaribe, and Pichinde), Filoviridae (Ebola and Marburg viruses), Flaviviridae (yellow fever, Omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).
Type:
Application
Filed:
March 2, 2007
Publication date:
February 5, 2009
Applicant:
SIGA TECHNOLOGIES, INC.
Inventors:
Dennis E. Hruby, Tove C. Bolken, Sean Amberg, Dongcheng Dai
Abstract: Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to, Arenaviridae (Junin, Machupo, Guanarito, Sabia, Lassa, Tacaribe, Pichinde, and LCMV), Filoviridae (Ebola and Marburg viruses), Flaviviridae (yellow fever, Omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever and Crimean-Congo hemorrhagic fever).
Type:
Application
Filed:
April 29, 2008
Publication date:
December 4, 2008
Applicant:
SIGA TECHNOLOGIES INC.
Inventors:
Dennis E. Hruby, Tove C. Bolken, Sean Amberg, Dongcheng Dai, Ryan A. Larson
Abstract: Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases cased by the orthopoxvirus.
Type:
Application
Filed:
June 18, 2004
Publication date:
May 1, 2008
Applicant:
Siga Technologies, Inc.
Inventors:
Robert Jordan, Thomas Bailey, Susan Rippin
Abstract: Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases cased by the orthopoxvirus.
Type:
Application
Filed:
April 23, 2007
Publication date:
January 3, 2008
Applicant:
SiGA Technologies, Inc.
Inventors:
Robert Jordan, Thomas Bailey, Susan Rippin, Dongcheng Dai
Abstract: Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases cased by the orthopoxvirus.
Type:
Application
Filed:
April 23, 2007
Publication date:
December 13, 2007
Applicant:
SiGA Technologies, Inc.
Inventors:
Robert Jordan, Thomas Bailey, Susan Rippin, Dongcheng Dai
Abstract: Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases cased by the orthopoxvirus.
Type:
Application
Filed:
June 18, 2004
Publication date:
October 19, 2006
Applicant:
Siga Technologies, Inc.
Inventors:
Robert Jordan, Thomas Bailey, Susan Rippin
Abstract: The focus of the present invention is an effective anti-poxvirus drug for use in treating or preventing human disease caused by pathogenic poxviruses. More particularly, the present invention relates to antiviral drugs that target the poxvirus proteinase responsible for core protein maturation, a step which is absolutely essential for the production and spread of infectious virions.
Type:
Grant
Filed:
January 8, 2003
Date of Patent:
June 27, 2006
Assignee:
Siga Technologies, Inc.
Inventors:
Dennis E. Hruby, Tove C. Bolken, Chelsea Byrd