Abstract: The present invention relates to a process for the preparation of hyaluronic acid butyrate, or a salt thereof, acceptable for pharmaceutical or cosmetic use or as a medical device, comprising reacting hyaluronic acid, salified with sodium or another alkali metal, in aqueous solution with butyryl-imidazolide in the presence of sodium carbonate. The present invention also relates to pharmaceutical formulations, cosmetic formulations or medical devices containing the hyaluronic acid sodium salt (HA) butyric esters produced by said process.
Abstract: Disclosed is the use of glycosaminoglycan esters, whose alcohol groups are partly esterified with lipoic acid or with lipoic acid and formic acid, in hair care treatments.
Type:
Grant
Filed:
March 7, 2016
Date of Patent:
May 16, 2017
Assignee:
SIGEA S.R.L.
Inventors:
Marco Bosco, Luca Stucchi, Matteo Fabbian, Fabrizio Picotti
Abstract: Disclosed is the use of glycosaminoglycan esters, whose alcohol groups are partly esterified with lipoic acid or with lipoic acid and formic acid, in hair are treatments.
Type:
Grant
Filed:
December 13, 2011
Date of Patent:
April 19, 2016
Assignee:
SIGEA S.R.L.
Inventors:
Marco Bosco, Luca Stucchi, Matteo Fabbian, Fabrizio Picotti
Abstract: Disclosed is the use of glycosaminoglycan esters, whose alcohol groups are partly esterified with lipoic acid or with lipoic acid and formic acid, in hair are treatments.
Type:
Application
Filed:
December 13, 2011
Publication date:
October 16, 2014
Applicant:
SIGEA S.R.L.
Inventors:
Marco Bosco, Luca Stucchi, Matteo Fabbian, Fabrizio Picotti
Abstract: Non-crosslinked derivatives of oligo/polysaccharides of formula wherein: X is OH, O?M, NH—R1, O—R1; M is an alkaline or alkaline-earth metal, transition metal, or cation containing a quaternary nitrogen atom; Y is H or R2; R1: the residue of an oligo/polysaccharide; R2: the residue of a C1-C4 linear chain aliphatic carboxylic acid or citric acid; provided that at least one X is NH—R1 or O—R1, while the other two X are present in acid (OH) or salified form (OM).
Type:
Grant
Filed:
December 18, 2007
Date of Patent:
January 14, 2014
Assignee:
Sigea S.R.L.
Inventors:
Marco Bosco, Luca Stucchi, Fabrizio Picotti, Rita Gianni
Abstract: Disclosed are polysaccharides containing residues of glucosamine or galactosamine in the repetitive unit, characterized by the presence of esters on the hydroxyls or amides on the amine functions, with lipoic acid or with mixtures of lipoic acid and formic acid.
Type:
Grant
Filed:
December 11, 2008
Date of Patent:
December 4, 2012
Assignee:
Sigea S.R.L.
Inventors:
Fabrizio Picotti, Marco Bosco, Luca Stucchi, Matteo Fabbian
Abstract: Disclosed are polysaccharides containing residues of glucosamine or galactosamine in the repetitive unit, characterised by the presence of esters on the hydroxyls or amides on the amine functions, with lipoic acid or with mixtures of lipoic acid and formic acid.
Type:
Application
Filed:
December 11, 2008
Publication date:
October 7, 2010
Applicant:
SIGEA S.R.L.
Inventors:
Fabrizio Picotti, Marco Bosco, Luca Stucchi, Matteo Fabbian
Abstract: A class of anionic and neutral complexes of ruthenium (II) containing nitrogen oxide (NO) and optionally a nitrogen ligand is described; a process for their preparation is also described. The preparation process includes the use of starting complexes of ruthenium (III) which are reacted with suitable reagents so as to obtain complexes containing NO coordinated to ruthenium (II). Additional substitution reactions allow the introduction of new groups that coordinate to the ruthenium atom, among which some nitrogen ligands.
Type:
Grant
Filed:
March 22, 2002
Date of Patent:
January 30, 2007
Assignee:
Sigea S.R.L.
Inventors:
Giovanni Mestroni, Enzo Alessio, Gianni Sava, Alberta Bergamo
Abstract: A salt of an anionic complex of Ru(III) with an ammonium cation fof formula (I),
where R1, R2 and R3, equal or different from each other, are selected from the group consisting of H, C1-C6 alkyl, linear or branched, saturated or unsaturated, C3-C7 cycloalkyl, phenyl and aryl; or NR1R2R3 is a 5-7-membered nitrogen-containing heterocycle, saturated or unsaturated, optionally containing one or more O, S and/or N atoms, said nitrogen atom being optionally substituted with a C1-C4 alkyl, aryl or benzyl residue; said nitrogen-containing heterocycle being optionally condensed with a benzo group and/or substituted with C1-C4 alkyl, C1-C4 alkoxyl, C1-C4 alkylthio, aryl or benzyl groups; where R4 and R5, equal or different from each other, are selected from the group consisting of H, C1-C6 alkyl, C3-C7 cycloalkyl, phenyl and aryl or R4 and R5 form, together with the S atom, a 4-7-membered heterocycle.
Type:
Grant
Filed:
December 30, 1998
Date of Patent:
April 24, 2001
Assignee:
Sigea S.r.l.
Inventors:
Giovanni Mestroni, Enzo Alessio, Gianni Sava