Abstract: A long-term effective patch structure includes a binding layer, an absorbing layer and a water-proof layer sequentially stacked together. The binding layer has a function of attaching and fixing, and is configured to be attached and fixed on a skin. Sweat or liquid from the skin can pass through the binding layer to reach the absorbing layer, which is aligned with binding layer at the edge. The water-proof layer is water-proof and has vapor permeability, and its area is larger than the area of the absorbing layer. The outer part of the water-proof layer is attachable to the skin. Since the absorbing layer can absorb the liquid from the skin and the water-proof layer can ventilate the vapor to the outside, the skin is kept dry and comfortable and suitable to be attached to human skin for a long period of time without inducing skin allergy or discomfort.