Patents Assigned to Sigma Tau Industrie Farvaceutiche Riunite S.p.A.
  • 7-Polyaminoalkyl(oxy)iminomethylcamptothecins bearing protective groups
    Patent number: 7612081
    Abstract: Compounds are disclosed with the general formula in which the groups are as defined in the description here below and characterized by the presence of polyamine substituents on the imine/oxime residue, such amine groups being in turn protected by suitable protective groups. Said compounds are endowed with potent topoisomerase I inhibiting activity and therefore are useful as medicaments for the treatment of tumors and viral and parasite infections.
    Type: Grant
    Filed: July 6, 2004
    Date of Patent: November 3, 2009
    Assignees: Istituto Nazionale per lo Studio e la Cura dei Tumori, Sigma Tau Industrie Farvaceutiche Riunite S.p.A.
    Inventors: Giuseppe Giannini, Claudio Pisano, Loredana Vesci, Maria Ornella Tinti, Lucio Merlini, Sergio Penco, Franco Zunino