Patents Assigned to Sigma-Tau
  • SYNTHESIS OF DEOXYBIOTINYL HEXAMETHYLENEDIAMINE-DOTA
    Publication number: 20100184972
    Abstract: A process for the synthesis of deoxybiotinyl hexamethylenediamine0-DOTA is herein described. Said process comprises reacting biotinyl hexamithylenediamine with tri-t-butyl DOTA in the presence of benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate, as the condensing agent, and triethylamine, as a base.
    Type: Application
    Filed: May 31, 2006
    Publication date: July 22, 2010
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Mauro Marzi, Maria Di Marzo
  • PHARMACEUTICAL COMPOSITION COMPRISING A CAMPOTHECIN DERIVATIVE
    Publication number: 20100166843
    Abstract: The present invention relates to pharmaceutical compositions comprising a topoisomerase I inhibitor including, but not limited to, a camptothecin derivative.
    Type: Application
    Filed: January 30, 2008
    Publication date: July 1, 2010
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Giancarlo Francese, Jörg Ogorka, Jia-ai Zhang
  • Alpha-ketoglutarates of active ingredients and compositions containing same
    Patent number: 7728037
    Abstract: Novel stable and pharmacologically acceptable salts of L-carnitine and lower alkanoyl L-carnitines with alpha-ketoglutaric acid are disclosed as well as the compositions useful as dietary and dietetic supplements, nutraceuticals or drugs containing same.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: June 1, 2010
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventor: Pietro Pola
  • Biphenyl and Naphthyl-Phenyl Hydroxamic Acid Derivatives
    Patent number: 7728039
    Abstract: Biphenyl and phenyl-naphthyl compounds bearing a hydroxamic group, which are endowed with antitumor, and anti-angiogenic activity These compounds are therefore particularly useful for the treatment of drug-resistant tumors.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: June 1, 2010
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Claudio Pisano, Giuseppe Giannini, Loredana Vesci, Franco Zunino, Sabrina Dallavalle, Lucio Merlini, Sergio Penco
  • Dealkylated derivatives of pyrrolo[2,1-b]benzothiazepines with atypical antipsychotic activity
    Patent number: 7713956
    Abstract: Derivatives of pyrrolo[2,1-b]benzothiazepines with formula (I) where A is CH—CH2C?CH; R is hydrogen, halogen, C1-C4 alkoxy, C1-C4 alkylthio, C1-C4 alkyl, C5-C6 cycloalkyl; R1 is 1-peperazinyl, 1-homopiperazinyl and 1-piperidinyl; R2 is hydrogen, C1-C4 alkoxy, C1-C4 alkylthio, C1-C4 alkyl, CHO, CH?NOH,CH2OH. The formula (I) compounds are endowed with characteristic atypical anti-psychotic activity, and are therefore useful as medicaments, in particular for the treatment and prevention of schizophrenia, paranoid states, manic-depressive states, disorders of the affective sphere, social regression, personality regression, and hallucinations. Said compounds also present advantageous pharmacokinetic properties.
    Type: Grant
    Filed: April 28, 2005
    Date of Patent: May 11, 2010
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Paolo Carminati, Maria Assunta Di Cesare, Orlando Ghirardi, Patrizia Minetti, Maria Ornella Tinti
  • AMIDE COMPOUNDS AND THEIR USE AS ANTITUMOR AGENTS
    Publication number: 20100113504
    Abstract: The present invention relates to a compound of Formula (I), its geometrical isomers, in an optically active form as enantiomers, diastereomers, as well as in the form of racemate, as well as pharmaceutically acceptable salts thereof, wherein R is selected from CONHOH, CONHCH2SH, CONHCH2SCOCH3, SH, SCOCH3, SCH3, N(OH)COH, COCONHCH3 and CF3 for the preparation of a medicament, in particular for selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells, for inducing differentiation of tumor cells in a tumor, for inhibiting the activity of histone deacetylase and for the treatment of primary cancer or secondary cancer.
    Type: Application
    Filed: March 12, 2008
    Publication date: May 6, 2010
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Stephan Hanessian, Luciana Auzzas, Giuseppe Giannini, Claudio Pisano, Loredana Vesci, Walter Cabri
  • Camptothecins conjugated in position 7 to cyclic peptides as cytostatic agents
    Patent number: 7705012
    Abstract: Compounds of Formula (I) are described in which the R1 group is as defined in the specification and includes the condensation of the camptothecin molecule in position 7 with a cyclopeptide containing the RGD sequence. Said compounds are endowed both with high affinity for integrin receptors ?v?3 and ?v?5 and with selective cytotoxic activity on human tumour cell lines at micromolar concentrations.
    Type: Grant
    Filed: May 4, 2005
    Date of Patent: April 27, 2010
    Assignees: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A., Instituto Nazionale per lo Studio e la Cura Dei Tumori
    Inventors: Claudio Pisano, Giuseppe Giannini, Maria Ornella Tinti, Loredana Vesci, Domenico Alloatti, Sergio Penco, Alma Dal Pozzo, Ni Minghong, Sabrina Dallavalle, Lucio Merlini, Franco Zunino
  • Use of 7-t-butoxyiminomethylcamptothecin for the preparation of a medicament for the treatment of uterine neoplasms
    Patent number: 7700613
    Abstract: The use of 7-ter-butoxyiminomethylcamptothecin is described in the preparation of a medicament useful for the treatment of uterine neoplasms, particularly cancer of the endometrium and of the neck of the womb.
    Type: Grant
    Filed: June 8, 2005
    Date of Patent: April 20, 2010
    Assignee: Sigma-Tau Farmaceutiche Riunite, S.p.A.
    Inventors: Paolo Carminati, Marco Corsi, Claudio Zanna, Franco Cavalli, Luca Gianni, Cristiana Sessa
  • USE OF L-CARNITINE OR OF ALKANOYL L-CARNITINES FOR THE PREPARATION OF A PHYSIOLOGICAL SUPPLEMENT OR MEDICAMENT FOR OPHTHALMIC USE IN THE FORM OF EYE DROPS
    Publication number: 20100093858
    Abstract: Use of L-carnitine and/or of one or more alkanoyl L-carnitines or one of their pharmaceutically acceptable salts for the preparation of an opthalmic physiological supplement or medicament in the form of eye-drops, for the treatment of corneal diseases.
    Type: Application
    Filed: December 18, 2009
    Publication date: April 15, 2010
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Aleardo Koverech, Nicola Pescosolido
  • Deglycosylated and desialidated long pentraxin PTX3
    Patent number: 7683032
    Abstract: Deglycosylated long pentraxin PTX3 and desialidated long pentraxin PTX3 are disclosed, as well as processes for their preparation, pharmacological compositions containing them, and their use for the preparation of a medicament for the treatment of diseases in which the use of the long pentraxin PTX is indicated, particularly infectious and inflammatory diseases and female fertility disorders. These proteins are endowed with therapeutic activity superior to that of glycosylated pentraxin.
    Type: Grant
    Filed: September 28, 2005
    Date of Patent: March 23, 2010
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Paolo Carminati, Rita De Santis, Antonio Inforzato, Giovanni Salvatori
  • GEL USEFUL FOR THE DELIVERY OF OPHTHALMIC DRUGS
    Publication number: 20100069482
    Abstract: It is described a gel composed of a mixture of a polymer which forms a gel, a buffer; a saccharide and one or more active ingredients useful for treating diseases of the eyes.
    Type: Application
    Filed: November 28, 2007
    Publication date: March 18, 2010
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Antonio Longo, Mosè Santaniello, Nicola Pescosolido, Aleardo Koverech
  • USE OF L-CARNITINE FOR THE PREPARATION OF A MEDICAMENT IN THE FORM OF EYE-DROPS FOR TREATING CORNEAL DISEASES
    Publication number: 20100068300
    Abstract: Use of L-carnitine or a pharmaceutically acceptable salt thereof, for the preparation of an opthalmic physiological supplement or medicament in the form of eye-drops, for the treatment of corneal oedema.
    Type: Application
    Filed: November 21, 2007
    Publication date: March 18, 2010
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Aleardo Koverech, Nicola Pescosolido
  • COMPOSITION USEFUL FOR THE PREVENTION OF TYPE 2 DIABETES AND ITS COMPLICATIONS IN PRE-DIABETIC PATIENTS WITH INSULIN RESISTANCE
    Publication number: 20100048691
    Abstract: The present invention relates to the use of acetyl L-carnitine in combination with an anti hypertensive drug, and a statin, for the preparation of a medicament for the prevention or delay of onset of type 2 diabetes and its complications, in pre-diabetic patients with insulin resistance.
    Type: Application
    Filed: March 21, 2008
    Publication date: February 25, 2010
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Claudio Cavazza, Paolo Carminati
  • BROAD-SPECTRUM ANTI-CANCER TREATMENT BASED ON IMINOCAMPTOTHECIN DERIVATIVES
    Publication number: 20100048603
    Abstract: A subclass of camptothecin derivatives is disclosed to be useful for the preparation of a medicament for the treatment of a cancer or tumor pathology selected from the group consisting of head and neck carcinoma, pancreas carcinoma, melanoma, bladder carcinoma, mesothelioma and epidermoid skin carcinoma.
    Type: Application
    Filed: February 7, 2008
    Publication date: February 25, 2010
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Claudio Pisano, Loredana Vesci, Franco Zunino
  • USE OF L-CARNITINE OR ALKANYL L-CARNITINE FOR THE PREPARATION OF A DIETARY SUPPLEMENT OR MEDICAMENT FOR THE TREATMENT OF CORNEAL DISEASE
    Publication number: 20100034795
    Abstract: Use of L-carnitine and/or one or more alkanoyl L-carnitines or one of their pharmaceutically acceptable salts for the preparation of a dietary supplement or medicament for the treatment of corneal diseases is disclosed.
    Type: Application
    Filed: June 30, 2006
    Publication date: February 11, 2010
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE IUNITE S.P.A.
    Inventors: Franco Gaetani, Janos Feher
  • COMPOSITION USEFUL FOR THE TREATMENT OF TYPE 2 DIABETES
    Publication number: 20100029759
    Abstract: It is described the use of L-canitine and/or an alkanoyl L-canitine, or a pharmaceutically acceptable salt thereof, in combination with a statin, for the preparation of a medicament for the treatment of type 2 diabetes.
    Type: Application
    Filed: November 20, 2007
    Publication date: February 4, 2010
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Franco Gaetani, Ashraf Virmani
  • Use of L-carnitine or of alkanoyl L-carnitines for the preparation of a physiological supplement or medicament for opthalmic use in the form of eye drops
    Patent number: 7655698
    Abstract: Use of L-carnitine and/or of one or more alkanoyl L-carnitines or one of their pharmaceutically acceptable salts for the preparation of an ophthalmic physiological supplement or medicament in the form of eye-drops, for the treatment of corneal diseases.
    Type: Grant
    Filed: December 14, 2006
    Date of Patent: February 2, 2010
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Aleardo Koverech, Nicola Pescosolido
  • Delayed release carnitine
    Patent number: 7655259
    Abstract: A sustained release, orally administered pharmaceutical composition comprising carnitine and an acceptable pharmaceutical excipient is described for the treatment of carnitine deficiency and other carnitine responsive conditions. The sustained release formulation avoids the characteristic problems of gastrointestinal invitation, dumping in the urine and bacterial degradation attendant previously known oral formulations of carnitine.
    Type: Grant
    Filed: February 2, 2007
    Date of Patent: February 2, 2010
    Assignee: SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A
    Inventors: Austin L. Shug, Carl E. Gulbrandsen
  • USE OF THYMOSIN ALPHA 1 FOR THE PREPARATION OF A MEDICAMENT FOR THE PREVENTION AND TREATMENT OF AUTOIMMUNE DISEASES
    Publication number: 20100004174
    Abstract: The invention concerns the use of thymosin alpha 1 for the preparation of a medicament for the prevention and treatment of autoimmune diseases such as multiple sclerosis, and inflammatory bowel diseases such as Crohn's disease or ulcerative colitis.
    Type: Application
    Filed: September 27, 2007
    Publication date: January 7, 2010
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE
    Inventors: Luigina Romani, Francesco Bistoni, Enrico Garaci, Guido Rasi, Paola Sinbaldi Vallebona
  • Compounds having reversible inhibiting activity of carnitine palmitoyl-transferase
    Patent number: RE41226
    Abstract: Compounds of formula (I) wherein the groups are as defined in the description are disclosed. The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine palmitoyl-transferase and are useful in the preparation of medicaments useful in the pathologies related to a hyperactivity of carnitine polymitoyl-transferase, such as hyperglycemia, diabetes and pathologies related thereto, heart failure, ischemia.
    Type: Grant
    Filed: December 1, 2006
    Date of Patent: April 13, 2010
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Fabio Giannessi, Mauro Marzi, Patrizia Minetti, Francesco De Angelis, Maria Ornella Tinti, Piero Chiodi, Arduino Arduini