Patents Assigned to Sigmoid Pharma Limited
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Patent number: 9402788Abstract: An extrusion process comprises extruding a material that is flowable when heated and passing the extrudate thus formed through a nozzle 10 to shape the extrudate into a plurality of substantially uniformly shaped elements such as minispheres or minicapsules.Type: GrantFiled: December 30, 2014Date of Patent: August 2, 2016Assignee: Sigmoid Pharma LimitedInventor: Ivan Coulter
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Publication number: 20160213611Abstract: A method for treating intestinal fibrosis in a subject, comprising enterally administering a steroid to the subject. The steroid may be in a multiple minibead formulation.Type: ApplicationFiled: April 4, 2016Publication date: July 28, 2016Applicant: Sigmoid Pharma LimitedInventors: Ivan Coulter, Vincenzo Aversa
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Patent number: 9387179Abstract: An oral cyclosporin composition comprises minicapsules having a core containing a cyclosporin, especially cyclosporin A in a solubilized liquid form. The minicapsules have a release profile to release the pre-solubilized cyclosporin, at least in the colon. The composition may be used for treating a range of intestinal diseases [FIG. 10].Type: GrantFiled: July 15, 2013Date of Patent: July 12, 2016Assignee: Sigmoid Pharma LimitedInventor: Ivan Coulter
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Publication number: 20160166635Abstract: An oral cyclosporin composition comprises minicapsules having a core containing a cyclosporin, especially cyclosporin A in a solubilised liquid form. The minicapsules have a release profile to release the pre-solubilised cyclosporin, at least in the colon. The composition may be used for treating a range of intestinal diseases [FIG. 10].Type: ApplicationFiled: February 23, 2016Publication date: June 16, 2016Applicant: Sigmoid Pharma LimitedInventor: Ivan Coulter
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Publication number: 20160143989Abstract: A composition comprises a water-soluble polymer matrix in which are dispersed droplets of oil, the composition comprising an active principle. The invention includes embodiments in which the active principle is included in at least some of the oil droplets as well as embodiments in which the oil droplets are free of active principle. The oil droplets are released as the matrix containing them dissolves in an aqueous medium. In one embodiment, the oil droplets are substantially immobilized in or by the matrix and the immobilizing feature is lost as the matrix dissolves in aqueous media. In certain embodiments, the oil drops may collectively be referred to as the oil phase of the composition of the invention. The product may be in the form of mini-beads. The oil phase and/or the polymer matrix may each include a surfactant.Type: ApplicationFiled: January 29, 2016Publication date: May 26, 2016Applicant: Sigmoid Pharma LimitedInventors: Ivan Coulter, Bernard Francis McDonald, Vincenzo Aversa
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Patent number: 9320746Abstract: A method for treating intestinal fibrosis in a subject, wherein the subject is medically considered to be suffering from intestinal fibrosis, the method comprising enterally administering a steroid to the subject, wherein the steroid is selected from: (i) steroids susceptible to first pass metabolism, (ii) corticosteroids, and (iii) aclometasone, aclometasone dipropionate, aldosterone, amcinonide, beclomethasone, beclomethasone dipropionate, betamethasone, betamethasone dipropionate, betamethasone sodium phosphate, betamethasone valerate, budesonide, clobetasone, clobetasone butyrate, clobetasol propionate, cloprednol, cortisone, cortisone acetate, cortivazol, deoxycortone, desonide, desoximetasone, dexamethasone, dexamethasone sodium phosphate, dexamethasone isonicotinate, difluorocortolone, fluclorolone, flumethasone, fluocinolone, fluocinolone acetonide, fluocinonide, fluocortin butyl, fluorocortisone, fluorocortolone, fluocortolone caproate, fluocortolone pivalate, fluorometholone, fluprednidene, fluprType: GrantFiled: February 20, 2014Date of Patent: April 26, 2016Assignee: Sigmoid Pharma LimitedInventors: Ivan Coulter, Vincenzo Aversa
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Patent number: 9278070Abstract: A composition comprises a water-soluble polymer matrix in which are dispersed droplets of oil, the composition comprising an active principle. The invention includes embodiments in which the active principle is included in at least some of the oil droplets as well as embodiments in which the oil droplets are free of active principle. The oil droplets are released as the matrix containing them dissolves in an aqueous medium. In one embodiment, the oil droplets are substantially immobilized in or by the matrix and the immobilizing feature is lost as the matrix dissolves in aqueous media. In certain embodiments, the oil drops may collectively be referred to as the oil phase of the composition of the invention. The product may be in the form of mini-beads. The oil phase and/or the polymer matrix may each include a surfactant.Type: GrantFiled: May 18, 2010Date of Patent: March 8, 2016Assignee: Sigmoid Pharma LimitedInventors: Ivan Coulter, Bernard Francis McDonald, Vincenzo Aversa
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Publication number: 20160045585Abstract: This invention relates to compositions for delivering one or more active ingredients, and more particularly to compositions, e.g. beads, comprising a matrix material which matrix material comprises a microorganism. In particular, the invention relates to compositions comprising a microorganism selected from live, killed, attenuated and inactivated microorganisms. The matrix material may also comprise a surfactant and may further comprise an adjuvant. The invention further relates to the manufacture and use of such compositions, and to other subject matter.Type: ApplicationFiled: October 27, 2015Publication date: February 18, 2016Applicant: SIGMOID PHARMA LIMITEDInventors: Ivan Coulter, Bernard Francis McDonald, Vincenzo Aversa, Monica Torres Rosa
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Publication number: 20150374638Abstract: An oral composition comprising minicapsules wherein the minicapsules comprise one or more therapeutic or prophylactic substances in a liquid, semi-liquid, or solid core. The minicapsules have release profiles to release the substance in an active form at one or more sites along the gastro-intestinal tract to maximise absorption and/or therapeutic efficiency.Type: ApplicationFiled: June 29, 2015Publication date: December 31, 2015Applicant: SIGMOID PHARMA LIMITEDInventor: Ivan Coulter
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Patent number: 9220681Abstract: This invention relates to compositions for delivering one or more active ingredients, and more particularly to compositions, e.g. beads, comprising a matrix material which matrix material comprises a microorganism. In particular, the invention relates to compositions comprising a microorganism selected from live, killed, attenuated and inactivated microorganisms. The matrix material may also comprise a surfactant and may further comprise an adjuvant. The invention further relates to the manufacture and use of such compositions, and to other subject matter.Type: GrantFiled: July 5, 2013Date of Patent: December 29, 2015Assignee: Sigmoid Pharma LimitedInventors: Ivan Coulter, Bernard Francis McDonald, Vincenzo Aversa, Mónica Rosa
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Publication number: 20150342893Abstract: An oral celecoxib formulation, the formulation being a multiple minibead formulation wherein the minibeads comprise a hydrogel-forming polymer matrix in which are distributed celecoxib, a polyoxyethylated non-ionic surfactant and an anionic surfactant, the minibeads when combined with water being capable of releasing self-assembly structures comprising surfactant and celecoxib. The formulation may be used for treating colorectal cancer, e.g. for inhibiting, reducing or delaying the initiation and/or progression of colorectal cancer, or for use in reversing colorectal cancer, reducing the burden of colorectal cancer and/or inducing remission of colorectal cancer, or for inhibiting, reducing or delaying metastasis of a colorectal cancer.Type: ApplicationFiled: May 27, 2015Publication date: December 3, 2015Applicant: SIGMOID PHARMA LIMITEDInventors: Ivan Coulter, Bernard Francis McDonald, Vincenzo Aversa
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Patent number: 9114071Abstract: An oral composition comprising minicapsules wherein the minicapsules comprise one or more therapeutic or prophylactic substances in a liquid, semi-liquid, or solid core. The minicapsules have release profiles to release the substance in an active form at one or more sites along the gastro-intestinal tract to maximize absorption and/or therapeutic efficiency.Type: GrantFiled: April 4, 2008Date of Patent: August 25, 2015Assignee: Sigmoid Pharma LimitedInventor: Ivan Coulter
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Publication number: 20150132374Abstract: A modified release composition comprising cyclosporin A for oral administration. The composition may comprise a core and a modified release coating, wherein the core comprises a hydrogel-forming polymer matrix and cyclosporin A. The composition may be in the form of a minibead. The compositions provide a pharmacokinetic profile and dissolution profile which provides release of cyclosporin A in the lower GI tract whilst minimising systemic exposure. Also disclosed are uses of the composition in the treatment of conditions affecting the lower GI tract, particularly the colon.Type: ApplicationFiled: November 7, 2014Publication date: May 14, 2015Applicant: SIGMOID PHARMA LIMITEDInventors: Ivan Coulter, Vincenzo Aversa, Mónica Rosa
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Publication number: 20150132396Abstract: The present invention relates to a formulation comprising a pharmaceutically active ingredient and a coating. The invention also relates to the use of the formulation in the treatment and prevention of disorders of the gastrointestinal tract. Also disclosed are methods for preparing the formulations.Type: ApplicationFiled: November 7, 2014Publication date: May 14, 2015Applicant: SIGMOID PHARMA LIMITEDInventors: Ivan Coulter, Vincenzo Aversa, Mónica Rosa, Bernard Francis McDonald
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Patent number: 8951570Abstract: An extrusion process comprises extruding a material that is flowable when heated and passing the extrudate thus formed through a nozzle 10 to shape the extrudate into a plurality of substantially uniformly shaped elements such as minispheres or minicapsules.Type: GrantFiled: April 25, 2008Date of Patent: February 10, 2015Assignee: Sigmoid Pharma LimitedInventor: Ivan Coulter
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Patent number: 8911777Abstract: An oral tacrolimus composition comprises minicapsules having a core containing tacrolimus in a solubilized liquid form. The minicapsules have a release profile to release the pre-solubilized tacrolimus throughout the entire gastrointestinal tract. The composition may be used, for example, for treatment or prevention of solid organ transplant rejection.Type: GrantFiled: April 4, 2008Date of Patent: December 16, 2014Assignee: Sigmoid Pharma LimitedInventor: Ivan Coulter
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Publication number: 20140234418Abstract: A method for treating intestinal fibrosis in a subject, comprising enterally administering a steroid to the subject. The steroid may be in a multiple minibead formulation.Type: ApplicationFiled: February 20, 2014Publication date: August 21, 2014Applicant: Sigmoid Pharma LimitedInventors: Ivan Coulter, Vincenzo Aversa
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Publication number: 20140017313Abstract: This invention relates to compositions for delivering one or more active ingredients, and more particularly to compositions, e.g. beads, comprising a matrix material which matrix material comprises a microorganism. In particular, the invention relates to compositions comprising a microorganism selected from live, killed, attenuated and inactivated microorganisms. The matrix material may also comprise a surfactant and may further comprise an adjuvant. The invention further relates to the manufacture and use of such compositions, and to other subject matter.Type: ApplicationFiled: July 5, 2013Publication date: January 16, 2014Applicant: Sigmoid Pharma LimitedInventors: Ivan Coulter, Bernard Francis McDonald, Vincenzo Aversa, Mónica Rosa
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Publication number: 20130243873Abstract: Immunomodulator formulations for use in the treatment of disease of the GI tract. The formulations comprise a hydroxylase inhibitor and/or an immunosuppressant. Exemplary formulations comprise hydralazine as a hydroxylase inhibitor and/or cyclosporin A as an immunosuppressant.Type: ApplicationFiled: November 25, 2011Publication date: September 19, 2013Applicant: Sigmoid Pharma LimitedInventors: Vincenzo Aversa, Ivan Coulter, Mónica Torres Rosa, Bernard Francis McDonald
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Patent number: 8535713Abstract: An oral cyclosporin composition comprises minicapsules having a core containing a cyclosporin, especially cyclosporin A in a solubilized liquid form. The minicapsules have a release profile to release the pre-solubilized cyclosporin, at least in the colon. The composition may be used for treating a range of intestinal diseases [FIG. 10].Type: GrantFiled: April 4, 2008Date of Patent: September 17, 2013Assignee: Sigmoid Pharma LimitedInventor: Ivan Coulter