Abstract: Vaccine compositions are disclosed for vaccinating a human or animal against herpes simplex virus infections. Also provided are methods of producing vaccines against herpes simplex virus and methods of using such vaccines to prevent or ameliorate herpes simplex virus-associated disease such as genital herpes.
Type:
Grant
Filed:
July 24, 2016
Date of Patent:
March 20, 2018
Assignee:
Sigmovir Biosystems, Inc.
Inventors:
Marina S. Boukhvalova, Jorge C. G. Blanco
Abstract: Methods and compositions are disclosed for improving vaccination in a subject with preexistent antibodies to the antigenic component of the immunizing vaccine. By temporarily sequestering, disabling, and/or suppressing preexistent antibodies and/or Fc-mediated mechanisms according to the various example embodiments, the target antigenic component of a vaccine has an increased opportunity to enter antigen-presenting cells through the same pathway that it would use in seronegative subjects. A balanced immune environment is thereby restored and B cells are properly activated to produce antigen-specific antibodies following vaccination.
Type:
Grant
Filed:
October 25, 2012
Date of Patent:
October 6, 2015
Assignee:
Sigmovir Biosystems, Inc.
Inventors:
Marina S. Boukhvalova, Jorge C. G. Blanco
Abstract: Methods, kits, and compositions are disclosed for vaccinating a human or animal against human rhinovirus infection. Also provided are methods of using a cotton rat model for identifying and testing vaccines and therapeutic agents that prevent or ameliorate human rhinovirus infection.
Type:
Grant
Filed:
September 13, 2013
Date of Patent:
September 1, 2015
Assignees:
Sigmovir Biosystems, Inc., Lovelace Respiratory Research Institute