Abstract: Processes for the preparation of Axitinib in good yield (generally greater than 80%) are provided that avoid the use of a palladium-catalyzed coupling reaction.
Type:
Grant
Filed:
April 27, 2016
Date of Patent:
February 28, 2017
Assignee:
Signa S.A. de C.V.
Inventors:
Evin Hazael Granados-Covarrubias, José Miguel Lazcano-Seres, Roberto Carlos Melgar-Fernández, Armando Zambrano-Huerta, Martín Raúl Montiel-Pérez, Israel Flores-García
Abstract: This invention relates to processes for the preparation of (R)-2-acetamido-N-benzyl-3-methoxypropionamide (I) and intermediates thereof. Formula (I).
Type:
Grant
Filed:
August 29, 2012
Date of Patent:
September 15, 2015
Assignee:
Signa S.A. de C.V.
Inventors:
Pablo Miguel Bernal-Vazquez, José Miguel Lazcano-Seres, Yaneth Mariá-Antonieta Contreras-Martinez, Jorge Alberto Juárez-Lagunas, Donato Sánchez-Mereles, Juan Rolando Vázquez-Miranda, Armando Zambrano-Huerta
Abstract: This invention relates to processes for the preparation of sodium 5,14-dihydrotetraazapentacene polysulfonate (1), and intermediates thereof.
Type:
Grant
Filed:
June 7, 2013
Date of Patent:
September 1, 2015
Assignee:
Signa S.A. de C.V.
Inventors:
José Miguel Lazcano-Seres, Cuauhtémoc Carrasco-Pacheco, Evin Hazael Granados-Covarrubias, Maria De la Luz Reyes-Reyes, Alberto Martinez-Díaz, Roberto Carlos Melgar-Fernández, Armando Zambrano-Huerta, Maria Viviana Cordero-Pensado, Edson Olimpo Sanchéz-López, Omar Gutiérrez-Cajero
Abstract: This invention relates to processes for the preparation of (R)-2-acetamido-N-benzyl-3-methoxypropionamide (I) and intermediates thereof. Formula (I).
Type:
Application
Filed:
August 29, 2012
Publication date:
January 22, 2015
Applicant:
SIGNA S.A. DE C.V.
Inventors:
Pablo Miguel Bernal-Vazquez, José Miguel Lazcano-Seres, Yaneth Mariá-Antonieta Contreras-Martinez, Jorge Alberto Juárez-Lagunas, Donato Sánchez-Mereles, Juan Rolando Vázquez-Miranda, Armando Zambrano-Huerta