Abstract: Conditionally-immortalized human CNS progenitor cell lines are provided. Such cell lines, which may be clonal, may be used to generate neurons and/or astrocytes. Such cell lines and/or differentiated cells may be used for the development of therapeutic agents to prevent and treat a variety of CNS-related diseases. Such cell lines and/or differentiated cells may also be used in assays and for the general study of CNS cell development, death and abnormalities.
Type:
Grant
Filed:
September 3, 1996
Date of Patent:
March 30, 2004
Assignee:
Signal Pharmaceuticials, Inc.
Inventors:
Dinah W. Y. Sah, Fred H. Gage, Jasodhara Ray