Abstract: Provided is an antibody or an antigen-binding fragment thereof capable of specifically binding to TNFR2, wherein the antibody or the antigen-binding fragment thereof is capable of regulating the function of immune cells and may be used as a medicament to treat diseases related to immune-related disorders, such as tumors. A polynucleotide encoding the antibody or antigen-binding fragment thereof and a pharmaceutical composition comprising the antibody or antigen binding fragment thereof are also provided.